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Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.
Life Sci 2007; 80(16):1466-71LS

Abstract

Delta(9)-tetrahydrocannabinol (Delta(9)-THC), a primary psychoactive constituent of cannabis, has been reported to act as a neuroprotectant via the cannabinoid CB(1) receptor. In this study, Delta(9)-THC significantly decreased the infarct volume in a 4 h mouse middle cerebral artery occlusion mouse model. The neuroprotective effect of Delta(9)-THC was completely abolished by SR141716, cannabinoid CB(1) receptor antagonist, and by warming the animals to 31 degrees C. Delta(9)-THC significantly decreased the rectal temperature, and the hypothermic effect was also inhibited by SR141716 and by warming to 31 degrees C. At 24 h after cerebral ischemia, Delta(9)-THC significantly increased the expression level of CB(1) receptor in both the striatum and cortex, but not in the hypothalamus. Warming to 31 degrees C during 4 h cerebral ischemia did not increase the expression of CB(1) receptor at the striatum and cortex in MCA-occluded mice. These results show that the neuroprotective effect of Delta(9)-THC is mediated by a temperature-dependent mechanism via the CB(1) receptor. In addition, warming to 31 degrees C might attenuate both the neuroprotective and hypothermic effects of Delta(9)-THC through inhibiting the increase in CB(1) receptor in both the striatum and cortex but not in the hypothalamus, which may suggest a new thermoregulation mechanism of Delta(9)-THC.

Authors+Show Affiliations

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Fukuoka City, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17289082

Citation

Hayakawa, Kazuhide, et al. "Delta9-tetrahydrocannabinol (Delta9-THC) Prevents Cerebral Infarction Via Hypothalamic-independent Hypothermia." Life Sciences, vol. 80, no. 16, 2007, pp. 1466-71.
Hayakawa K, Mishima K, Nozako M, et al. Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sci. 2007;80(16):1466-71.
Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Ogata, A., Fujioka, M., ... Fujiwara, M. (2007). Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sciences, 80(16), pp. 1466-71.
Hayakawa K, et al. Delta9-tetrahydrocannabinol (Delta9-THC) Prevents Cerebral Infarction Via Hypothalamic-independent Hypothermia. Life Sci. 2007 Mar 27;80(16):1466-71. PubMed PMID: 17289082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. AU - Hayakawa,Kazuhide, AU - Mishima,Kenichi, AU - Nozako,Masanori, AU - Hazekawa,Mai, AU - Ogata,Ayumi, AU - Fujioka,Masayuki, AU - Harada,Kazuhiko, AU - Mishima,Shohei, AU - Orito,Kensuke, AU - Egashira,Nobuaki, AU - Iwasaki,Katunori, AU - Fujiwara,Michihiro, Y1 - 2007/01/19/ PY - 2006/10/06/received PY - 2006/12/28/revised PY - 2007/01/06/accepted PY - 2007/2/10/pubmed PY - 2007/6/29/medline PY - 2007/2/10/entrez SP - 1466 EP - 71 JF - Life sciences JO - Life Sci. VL - 80 IS - 16 N2 - Delta(9)-tetrahydrocannabinol (Delta(9)-THC), a primary psychoactive constituent of cannabis, has been reported to act as a neuroprotectant via the cannabinoid CB(1) receptor. In this study, Delta(9)-THC significantly decreased the infarct volume in a 4 h mouse middle cerebral artery occlusion mouse model. The neuroprotective effect of Delta(9)-THC was completely abolished by SR141716, cannabinoid CB(1) receptor antagonist, and by warming the animals to 31 degrees C. Delta(9)-THC significantly decreased the rectal temperature, and the hypothermic effect was also inhibited by SR141716 and by warming to 31 degrees C. At 24 h after cerebral ischemia, Delta(9)-THC significantly increased the expression level of CB(1) receptor in both the striatum and cortex, but not in the hypothalamus. Warming to 31 degrees C during 4 h cerebral ischemia did not increase the expression of CB(1) receptor at the striatum and cortex in MCA-occluded mice. These results show that the neuroprotective effect of Delta(9)-THC is mediated by a temperature-dependent mechanism via the CB(1) receptor. In addition, warming to 31 degrees C might attenuate both the neuroprotective and hypothermic effects of Delta(9)-THC through inhibiting the increase in CB(1) receptor in both the striatum and cortex but not in the hypothalamus, which may suggest a new thermoregulation mechanism of Delta(9)-THC. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/17289082/abstract/Delta_9__tetrahydrocannabinol__Delta_9__THC__prevents_cerebral_infarction_via_hypothalamic_independent_hypothermia L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(07)00063-X DB - PRIME DP - Unbound Medicine ER -