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Neuro-immune interactions via the cholinergic anti-inflammatory pathway.
Life Sci. 2007 May 30; 80(24-25):2325-9.LS

Abstract

The overproduction of TNF and other cytokines is associated with the pathophysiology of numerous diseases. Controlling cytokine synthesis and release is critical for preventing unrestrained inflammation and maintaining health. Recent studies identified an efferent vagus nerve-based mechanism termed "the cholinergic anti-inflammatory pathway" that controls cytokine production and inflammation. Here we review current advances related to the role of this pathway in neuro-immune interactions that prevent excessive inflammation. Experimental evidence indicates that vagus nerve cholinergic anti-inflammatory signaling requires alpha7 nicotinic acetylcholine receptors expressed on non-neuronal cytokine-producing cells. Alpha7 nicotinic acetylcholine receptor agonists inhibit cytokine release and protect animals in a variety of experimental lethal inflammatory models. Knowledge related to the cholinergic anti-inflammatory pathway can be exploited in therapeutic approaches directed towards counteracting abnormal chronic and hyper-activated inflammatory responses.

Authors+Show Affiliations

Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17289087

Citation

Gallowitsch-Puerta, Margot, and Valentin A. Pavlov. "Neuro-immune Interactions Via the Cholinergic Anti-inflammatory Pathway." Life Sciences, vol. 80, no. 24-25, 2007, pp. 2325-9.
Gallowitsch-Puerta M, Pavlov VA. Neuro-immune interactions via the cholinergic anti-inflammatory pathway. Life Sci. 2007;80(24-25):2325-9.
Gallowitsch-Puerta, M., & Pavlov, V. A. (2007). Neuro-immune interactions via the cholinergic anti-inflammatory pathway. Life Sciences, 80(24-25), 2325-9.
Gallowitsch-Puerta M, Pavlov VA. Neuro-immune Interactions Via the Cholinergic Anti-inflammatory Pathway. Life Sci. 2007 May 30;80(24-25):2325-9. PubMed PMID: 17289087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuro-immune interactions via the cholinergic anti-inflammatory pathway. AU - Gallowitsch-Puerta,Margot, AU - Pavlov,Valentin A, Y1 - 2007/01/13/ PY - 2006/11/01/received PY - 2006/12/19/revised PY - 2007/01/06/accepted PY - 2007/2/10/pubmed PY - 2007/8/2/medline PY - 2007/2/10/entrez SP - 2325 EP - 9 JF - Life sciences JO - Life Sci VL - 80 IS - 24-25 N2 - The overproduction of TNF and other cytokines is associated with the pathophysiology of numerous diseases. Controlling cytokine synthesis and release is critical for preventing unrestrained inflammation and maintaining health. Recent studies identified an efferent vagus nerve-based mechanism termed "the cholinergic anti-inflammatory pathway" that controls cytokine production and inflammation. Here we review current advances related to the role of this pathway in neuro-immune interactions that prevent excessive inflammation. Experimental evidence indicates that vagus nerve cholinergic anti-inflammatory signaling requires alpha7 nicotinic acetylcholine receptors expressed on non-neuronal cytokine-producing cells. Alpha7 nicotinic acetylcholine receptor agonists inhibit cytokine release and protect animals in a variety of experimental lethal inflammatory models. Knowledge related to the cholinergic anti-inflammatory pathway can be exploited in therapeutic approaches directed towards counteracting abnormal chronic and hyper-activated inflammatory responses. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/17289087/Neuro_immune_interactions_via_the_cholinergic_anti_inflammatory_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(07)00033-1 DB - PRIME DP - Unbound Medicine ER -