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Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.
Neurosci Lett. 2007 Mar 19; 415(1):68-72.NL

Abstract

Previously we have shown that angiotensin II (Ang II) suppresses long-term potentiation (LTP) in the lateral nucleus of the amygdala (LA) of horizontal slices. This study examines the effect of Ang II on long-term depression (LTD) in the LA. Low frequency stimulation (1 Hz, 15 min; LFS) applied to fibers running within the LA induced a long-lasting reduction of the amplitudes of field potentials in the LA of mice. We have previously shown that this LTD is sensitive to the NMDA receptor blocker D-AP5 and is dependent on group II mGlu receptors. Ang II blocked dose-dependent LTD. Losartan, an AT1 receptor antagonist, blocked the Ang II-induced suppression of LTD, whereas PD 123 319, an AT2 receptor antagonist, had no effect. Co-administration of nifedipine, an L-type calcium channel antagonist, abolished Ang II-induced suppression of LTD. When applied alone nifedipine reduced the magnitude of LA-LTD. According to our previous results, stimulation of external capsule (EC) fibers in rats did not cause LTD in mice. Similarly, Ang II did not induce long-lasting changes of activity when EC stimulation site was used. The results support the view that angiotensins are involved in mechanisms of learning and memory including the plasticity changes in the LA.

Authors+Show Affiliations

Institute of Neurobiology, Acad. G. Bonchev Str., Bl. 23, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17289261

Citation

Tchekalarova, Jana, and Doris Albrecht. "Angiotensin II Suppresses Long-term Depression in the Lateral Amygdala of Mice Via L-type Calcium Channels." Neuroscience Letters, vol. 415, no. 1, 2007, pp. 68-72.
Tchekalarova J, Albrecht D. Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels. Neurosci Lett. 2007;415(1):68-72.
Tchekalarova, J., & Albrecht, D. (2007). Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels. Neuroscience Letters, 415(1), 68-72.
Tchekalarova J, Albrecht D. Angiotensin II Suppresses Long-term Depression in the Lateral Amygdala of Mice Via L-type Calcium Channels. Neurosci Lett. 2007 Mar 19;415(1):68-72. PubMed PMID: 17289261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels. AU - Tchekalarova,Jana, AU - Albrecht,Doris, Y1 - 2006/12/30/ PY - 2006/09/15/received PY - 2006/12/11/revised PY - 2006/12/27/accepted PY - 2007/2/10/pubmed PY - 2007/5/26/medline PY - 2007/2/10/entrez SP - 68 EP - 72 JF - Neuroscience letters JO - Neurosci Lett VL - 415 IS - 1 N2 - Previously we have shown that angiotensin II (Ang II) suppresses long-term potentiation (LTP) in the lateral nucleus of the amygdala (LA) of horizontal slices. This study examines the effect of Ang II on long-term depression (LTD) in the LA. Low frequency stimulation (1 Hz, 15 min; LFS) applied to fibers running within the LA induced a long-lasting reduction of the amplitudes of field potentials in the LA of mice. We have previously shown that this LTD is sensitive to the NMDA receptor blocker D-AP5 and is dependent on group II mGlu receptors. Ang II blocked dose-dependent LTD. Losartan, an AT1 receptor antagonist, blocked the Ang II-induced suppression of LTD, whereas PD 123 319, an AT2 receptor antagonist, had no effect. Co-administration of nifedipine, an L-type calcium channel antagonist, abolished Ang II-induced suppression of LTD. When applied alone nifedipine reduced the magnitude of LA-LTD. According to our previous results, stimulation of external capsule (EC) fibers in rats did not cause LTD in mice. Similarly, Ang II did not induce long-lasting changes of activity when EC stimulation site was used. The results support the view that angiotensins are involved in mechanisms of learning and memory including the plasticity changes in the LA. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/17289261/Angiotensin_II_suppresses_long_term_depression_in_the_lateral_amygdala_of_mice_via_L_type_calcium_channels_ DB - PRIME DP - Unbound Medicine ER -