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Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease. Overall findings and differences by age for 316,099 white men. Multiple Risk Factor Intervention Trial Research Group.
Arch Intern Med 1992; 152(1):56-64AI

Abstract

To assess the combined influence of blood pressure (BP), serum cholesterol level, and cigarette smoking on death from coronary heart disease (CHD) and to describe how these associations vary with age, data on those factors and on mortality for 316,099 men screened for the Multiple Risk Factor Intervention Trial (MRFIT) were examined. Vital status of participants has been determined after an average follow-up of 12 years; 6327 deaths from CHD have been identified. Strong graded relationships between serum cholesterol levels above 4.65 mmol/L (180 mg/dL), systolic BP above 110 mm Hg, and diastolic BP above 70 mm Hg and mortality due to CHD were evident. Smokers with serum cholesterol and systolic BP levels in the highest quintiles had CHD death rates that were approximately 20 times greater than nonsmoking men with systolic BP and cholesterol levels in the lowest quintile. Systolic and diastolic BP, serum cholesterol level, and cigarettes per day were significant predictors of death due to CHD in all age groups. Systolic BP was a stronger predictor than diastolic BP. These results, together with the findings of clinical trials, offer strong support for intensified preventive efforts in all age groups.

Authors+Show Affiliations

Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis 55414.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1728930

Citation

Neaton, J D., and D Wentworth. "Serum Cholesterol, Blood Pressure, Cigarette Smoking, and Death From Coronary Heart Disease. Overall Findings and Differences By Age for 316,099 White Men. Multiple Risk Factor Intervention Trial Research Group." Archives of Internal Medicine, vol. 152, no. 1, 1992, pp. 56-64.
Neaton JD, Wentworth D. Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease. Overall findings and differences by age for 316,099 white men. Multiple Risk Factor Intervention Trial Research Group. Arch Intern Med. 1992;152(1):56-64.
Neaton, J. D., & Wentworth, D. (1992). Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease. Overall findings and differences by age for 316,099 white men. Multiple Risk Factor Intervention Trial Research Group. Archives of Internal Medicine, 152(1), pp. 56-64.
Neaton JD, Wentworth D. Serum Cholesterol, Blood Pressure, Cigarette Smoking, and Death From Coronary Heart Disease. Overall Findings and Differences By Age for 316,099 White Men. Multiple Risk Factor Intervention Trial Research Group. Arch Intern Med. 1992;152(1):56-64. PubMed PMID: 1728930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease. Overall findings and differences by age for 316,099 white men. Multiple Risk Factor Intervention Trial Research Group. AU - Neaton,J D, AU - Wentworth,D, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 56 EP - 64 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 152 IS - 1 N2 - To assess the combined influence of blood pressure (BP), serum cholesterol level, and cigarette smoking on death from coronary heart disease (CHD) and to describe how these associations vary with age, data on those factors and on mortality for 316,099 men screened for the Multiple Risk Factor Intervention Trial (MRFIT) were examined. Vital status of participants has been determined after an average follow-up of 12 years; 6327 deaths from CHD have been identified. Strong graded relationships between serum cholesterol levels above 4.65 mmol/L (180 mg/dL), systolic BP above 110 mm Hg, and diastolic BP above 70 mm Hg and mortality due to CHD were evident. Smokers with serum cholesterol and systolic BP levels in the highest quintiles had CHD death rates that were approximately 20 times greater than nonsmoking men with systolic BP and cholesterol levels in the lowest quintile. Systolic and diastolic BP, serum cholesterol level, and cigarettes per day were significant predictors of death due to CHD in all age groups. Systolic BP was a stronger predictor than diastolic BP. These results, together with the findings of clinical trials, offer strong support for intensified preventive efforts in all age groups. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/1728930/Serum_cholesterol_blood_pressure_cigarette_smoking_and_death_from_coronary_heart_disease__Overall_findings_and_differences_by_age_for_316099_white_men__Multiple_Risk_Factor_Intervention_Trial_Research_Group_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/152/pg/56 DB - PRIME DP - Unbound Medicine ER -