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Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry.
J Pharm Biomed Anal. 2007 Apr 11; 43(5):1692-9.JP

Abstract

Atmospheric pressure chemical ionization mass spectrometry (APCI-MS) was operated in positive mode (PI) to characterize polymethoxylated flavonoids (PMFs) through its specific radical cations by collision-induced dissociation (CID). The fragments of [M + H - n x 15]+ produced by loss of one or more methyl group from the protonated molecule, as well as [M + H - 29]+, [M + H - 31]+, [M + H - 33]+, [M + H - 43]+, [M + H - 46]+, and [M + H - 61]+ fragment ions were detected, which were diagnostic for the polymethoxylated species, and could be adopted to form the multiple MS (MS(n)) "fingerprint" of PMFs. Based on this "fingerprint", 29 PMFs were screened out from extracts of Fructus aurantii, among which two of them were identified as sinensetin and tangeretin. It was proved that the PI was suitable for structural characterization of PMFs by APCI-MS(n).

Authors+Show Affiliations

Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17291708

Citation

Zhou, Da-Yong, et al. "Characterization of Polymethoxylated Flavones in Fructus Aurantii By Liquid Chromatography With Atmospheric Pressure Chemical Ionization Combined With Tandem Mass Spectrometry." Journal of Pharmaceutical and Biomedical Analysis, vol. 43, no. 5, 2007, pp. 1692-9.
Zhou DY, Chen DL, Xu Q, et al. Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry. J Pharm Biomed Anal. 2007;43(5):1692-9.
Zhou, D. Y., Chen, D. L., Xu, Q., Xue, X. Y., Zhang, F. F., & Liang, X. M. (2007). Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 43(5), 1692-9.
Zhou DY, et al. Characterization of Polymethoxylated Flavones in Fructus Aurantii By Liquid Chromatography With Atmospheric Pressure Chemical Ionization Combined With Tandem Mass Spectrometry. J Pharm Biomed Anal. 2007 Apr 11;43(5):1692-9. PubMed PMID: 17291708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry. AU - Zhou,Da-Yong, AU - Chen,De-Liang, AU - Xu,Qing, AU - Xue,Xing-Ya, AU - Zhang,Fei-Fang, AU - Liang,Xin-Miao, Y1 - 2007/01/10/ PY - 2006/08/31/received PY - 2006/12/20/revised PY - 2006/12/28/accepted PY - 2007/2/13/pubmed PY - 2007/6/19/medline PY - 2007/2/13/entrez SP - 1692 EP - 9 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 43 IS - 5 N2 - Atmospheric pressure chemical ionization mass spectrometry (APCI-MS) was operated in positive mode (PI) to characterize polymethoxylated flavonoids (PMFs) through its specific radical cations by collision-induced dissociation (CID). The fragments of [M + H - n x 15]+ produced by loss of one or more methyl group from the protonated molecule, as well as [M + H - 29]+, [M + H - 31]+, [M + H - 33]+, [M + H - 43]+, [M + H - 46]+, and [M + H - 61]+ fragment ions were detected, which were diagnostic for the polymethoxylated species, and could be adopted to form the multiple MS (MS(n)) "fingerprint" of PMFs. Based on this "fingerprint", 29 PMFs were screened out from extracts of Fructus aurantii, among which two of them were identified as sinensetin and tangeretin. It was proved that the PI was suitable for structural characterization of PMFs by APCI-MS(n). SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/17291708/Characterization_of_polymethoxylated_flavones_in_Fructus_aurantii_by_liquid_chromatography_with_atmospheric_pressure_chemical_ionization_combined_with_tandem_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(07)00011-8 DB - PRIME DP - Unbound Medicine ER -