Tags

Type your tag names separated by a space and hit enter

Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study.
J Allergy Clin Immunol 2007; 119(2):307-13JA

Abstract

BACKGROUND

Early life allergen exposure may increase the risk of childhood allergy, but the protective effect of reduction in allergen exposure remains uncertain.

OBJECTIVE

To evaluate the effect of reduction in food and house dust mite (HDM) allergen exposure in infancy in preventing asthma and allergy.

METHODS

Infants, at higher risk because of family predisposition, were recruited prenatally and randomized to prophylactic (n = 58) and control (n = 62) groups. Prophylactic group infants were either breast-fed with mother on a low allergen diet or given an extensively hydrolyzed formula. Exposure to HDM was reduced by the use of an acaricide and mattress covers. The control group followed standard advice. Development of allergic diseases and sensitization to common allergens (atopy) was assessed blindly at ages 1, 2, 4, and 8 years in all 120 children.

RESULTS

Repeated measurement analysis, adjusted for all relevant confounding variables, confirmed a preventive effect on asthma: adjusted odds ratio (OR), 0.24; 95% CI, 0.09-0.66; P = .005; atopic dermatitis, OR, 0.23; CI, 0.08-0.64; P = .005; rhinitis, OR, 0.42; CI, 0.19-0.92; P = .03; and atopy, OR, 0.13; CI, 0.05-0.32; P < .001. The protective effect was primarily observed in the subgroup of children with persistent disease (symptoms at all visits) and in those with evidence of allergic sensitization.

CONCLUSION

Allergic diseases can be reduced, for at least the first 8 years of life, by combined food and HDM allergen avoidance in infancy.

CLINICAL IMPLICATIONS

Strict food and HDM allergen avoidance should be considered for prevention of allergy in high-risk infants.

Authors+Show Affiliations

David Hide Asthma and Allergy Research Center, St Mary's Hospital, Newport, Isle of Wight, UK. sha@soton.ac.uk <sha@soton.ac.uk>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17291851

Citation

Arshad, Syed Hasan, et al. "Prevention of Allergic Disease During Childhood By Allergen Avoidance: the Isle of Wight Prevention Study." The Journal of Allergy and Clinical Immunology, vol. 119, no. 2, 2007, pp. 307-13.
Arshad SH, Bateman B, Sadeghnejad A, et al. Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study. J Allergy Clin Immunol. 2007;119(2):307-13.
Arshad, S. H., Bateman, B., Sadeghnejad, A., Gant, C., & Matthews, S. M. (2007). Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study. The Journal of Allergy and Clinical Immunology, 119(2), pp. 307-13.
Arshad SH, et al. Prevention of Allergic Disease During Childhood By Allergen Avoidance: the Isle of Wight Prevention Study. J Allergy Clin Immunol. 2007;119(2):307-13. PubMed PMID: 17291851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study. AU - Arshad,Syed Hasan, AU - Bateman,Belinda, AU - Sadeghnejad,Alireza, AU - Gant,Carole, AU - Matthews,Sharon M, PY - 2006/11/10/received PY - 2006/12/11/revised PY - 2006/12/14/accepted PY - 2007/2/13/pubmed PY - 2007/3/14/medline PY - 2007/2/13/entrez SP - 307 EP - 13 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 119 IS - 2 N2 - BACKGROUND: Early life allergen exposure may increase the risk of childhood allergy, but the protective effect of reduction in allergen exposure remains uncertain. OBJECTIVE: To evaluate the effect of reduction in food and house dust mite (HDM) allergen exposure in infancy in preventing asthma and allergy. METHODS: Infants, at higher risk because of family predisposition, were recruited prenatally and randomized to prophylactic (n = 58) and control (n = 62) groups. Prophylactic group infants were either breast-fed with mother on a low allergen diet or given an extensively hydrolyzed formula. Exposure to HDM was reduced by the use of an acaricide and mattress covers. The control group followed standard advice. Development of allergic diseases and sensitization to common allergens (atopy) was assessed blindly at ages 1, 2, 4, and 8 years in all 120 children. RESULTS: Repeated measurement analysis, adjusted for all relevant confounding variables, confirmed a preventive effect on asthma: adjusted odds ratio (OR), 0.24; 95% CI, 0.09-0.66; P = .005; atopic dermatitis, OR, 0.23; CI, 0.08-0.64; P = .005; rhinitis, OR, 0.42; CI, 0.19-0.92; P = .03; and atopy, OR, 0.13; CI, 0.05-0.32; P < .001. The protective effect was primarily observed in the subgroup of children with persistent disease (symptoms at all visits) and in those with evidence of allergic sensitization. CONCLUSION: Allergic diseases can be reduced, for at least the first 8 years of life, by combined food and HDM allergen avoidance in infancy. CLINICAL IMPLICATIONS: Strict food and HDM allergen avoidance should be considered for prevention of allergy in high-risk infants. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/17291851/Prevention_of_allergic_disease_during_childhood_by_allergen_avoidance:_the_Isle_of_Wight_prevention_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(06)03813-9 DB - PRIME DP - Unbound Medicine ER -