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Preparation and characterization of glutaraldehyde cross-linked O-carboxymethylchitosan microspheres for controlled delivery of pazufloxacin mesilate.
Int J Biol Macromol. 2007 Jun 01; 41(1):87-93.IJ

Abstract

O-carboxymethylchitosan (OCMC) microspheres containing an antibiotic drug pazufloxacin mesilate (PM) have been successfully prepared by emulsion cross-linking using glutaraldehyde (GA). Various manufacturing parameters, including amount of cross-linking agent and OCMC:PM ratios were altered to optimize process variables during the microspheres production. The structure and morphology were characterized by Fourier transform infrared (FT-IR), wide-angle X-ray diffraction (WXRD) and scanning electron microscopy (SEM). The swelling and releasing behaviors of the microspheres at pH 1.2 and 7.4 media were investigated. The results revealed that the microspheres had a spherical, rough morphology and with a narrow size distribution. The degree of swelling of microspheres at pH 7.4 media was higher than that at pH 1.2 media. The microspheres proved to be successful in prolonging drug release. The release of PM was found to depend upon the extent of matrix cross-linking and drug loading. The release profiles of PM from OCMC microspheres were found to be biphasic with a burst release followed by a gradual release phase, and followed the Higuchi matrix model.

Authors+Show Affiliations

College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17292465

Citation

Liu, Yan-Fei, et al. "Preparation and Characterization of Glutaraldehyde Cross-linked O-carboxymethylchitosan Microspheres for Controlled Delivery of Pazufloxacin Mesilate." International Journal of Biological Macromolecules, vol. 41, no. 1, 2007, pp. 87-93.
Liu YF, Huang KL, Peng DM, et al. Preparation and characterization of glutaraldehyde cross-linked O-carboxymethylchitosan microspheres for controlled delivery of pazufloxacin mesilate. Int J Biol Macromol. 2007;41(1):87-93.
Liu, Y. F., Huang, K. L., Peng, D. M., Ding, P., & Li, G. Y. (2007). Preparation and characterization of glutaraldehyde cross-linked O-carboxymethylchitosan microspheres for controlled delivery of pazufloxacin mesilate. International Journal of Biological Macromolecules, 41(1), 87-93.
Liu YF, et al. Preparation and Characterization of Glutaraldehyde Cross-linked O-carboxymethylchitosan Microspheres for Controlled Delivery of Pazufloxacin Mesilate. Int J Biol Macromol. 2007 Jun 1;41(1):87-93. PubMed PMID: 17292465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of glutaraldehyde cross-linked O-carboxymethylchitosan microspheres for controlled delivery of pazufloxacin mesilate. AU - Liu,Yan-Fei, AU - Huang,Ke-Long, AU - Peng,Dong-Ming, AU - Ding,Ping, AU - Li,Gui-Yin, Y1 - 2007/01/19/ PY - 2006/11/30/received PY - 2007/01/04/revised PY - 2007/01/08/accepted PY - 2007/2/13/pubmed PY - 2007/6/1/medline PY - 2007/2/13/entrez SP - 87 EP - 93 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 41 IS - 1 N2 - O-carboxymethylchitosan (OCMC) microspheres containing an antibiotic drug pazufloxacin mesilate (PM) have been successfully prepared by emulsion cross-linking using glutaraldehyde (GA). Various manufacturing parameters, including amount of cross-linking agent and OCMC:PM ratios were altered to optimize process variables during the microspheres production. The structure and morphology were characterized by Fourier transform infrared (FT-IR), wide-angle X-ray diffraction (WXRD) and scanning electron microscopy (SEM). The swelling and releasing behaviors of the microspheres at pH 1.2 and 7.4 media were investigated. The results revealed that the microspheres had a spherical, rough morphology and with a narrow size distribution. The degree of swelling of microspheres at pH 7.4 media was higher than that at pH 1.2 media. The microspheres proved to be successful in prolonging drug release. The release of PM was found to depend upon the extent of matrix cross-linking and drug loading. The release profiles of PM from OCMC microspheres were found to be biphasic with a burst release followed by a gradual release phase, and followed the Higuchi matrix model. SN - 0141-8130 UR - https://www.unboundmedicine.com/medline/citation/17292465/Preparation_and_characterization_of_glutaraldehyde_cross_linked_O_carboxymethylchitosan_microspheres_for_controlled_delivery_of_pazufloxacin_mesilate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(07)00007-4 DB - PRIME DP - Unbound Medicine ER -