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HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy.
J Immunol. 1992 Jan 15; 148(2):411-6.JI

Abstract

MHC haplotypes were determined for 52 patients with ragweed pollen allergy, with and without asthma, and 27 non-atopic controls. Total IgE levels were unimodally distributed in all study groups and were higher in atopic patients in general compared with non-atopics. There was no difference in total IgE levels in patients with rhinitis only compared with those with rhinitis and asthma. IgE anti-Amb a V was detected (after subtraction of values representing the means + 2 SD of the non-atopics) in 9 of 20 asthmatics but only 3 of 32 patients with only rhinitis and was thus associated with asthma. Mean anti-Amb a V was much higher in the antibody-positive asthmatics (1710 U/ml) than in the positive patients with rhinitis only (469 U/ml). The extended MHC haplotype [HLA-B7, SC31, DR2] and its possible DR-containing fragment (SC31, DR2), were found almost exclusively among the patients with IgE anti-Amb a V and were significantly elevated in patients with asthma. DR2 in general, but not DR2 without SC31, was significantly increased in frequency in patients with anti-Amb a V. In contrast, the extended haplotype [HLA-B8, SC01, DR3] and DR3 in general were increased among patients with rhinitis only and patients without IgE anti-Amb a V compared with general controls. Thus, [HLA-B8, SC01, DR3] and DR3 appear to be "protective" for the production of this antibody and the occurrence of asthma. The findings are consistent with an MHC-linked gene or genes on [HLA-B7, SC31, DR2] (but not necessarily DR2, Dw2, or DQw6 in general) controlling the IgE immune response to Amb a V and associated with asthma in ragweed pollen-sensitive subjects. In patients with rhinitis alone and generally undetectable levels of IgE anti-Amb a V, the increase in [HLA-B8, SC01, DR3] and DR3 may mark a response to an as yet unidentified Ag associated with ragweed allergy and rhinitis only.

Authors+Show Affiliations

Department of Medicine, University of Minnesota, Minneapolis 55455.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1729361

Citation

Blumenthal, M, et al. "HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] Haplotypes Distinguish Subjects With Asthma From Those With Rhinitis Only in Ragweed Pollen Allergy." Journal of Immunology (Baltimore, Md. : 1950), vol. 148, no. 2, 1992, pp. 411-6.
Blumenthal M, Marcus-Bagley D, Awdeh Z, et al. HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy. J Immunol. 1992;148(2):411-6.
Blumenthal, M., Marcus-Bagley, D., Awdeh, Z., Johnson, B., Yunis, E. J., & Alper, C. A. (1992). HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy. Journal of Immunology (Baltimore, Md. : 1950), 148(2), 411-6.
Blumenthal M, et al. HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] Haplotypes Distinguish Subjects With Asthma From Those With Rhinitis Only in Ragweed Pollen Allergy. J Immunol. 1992 Jan 15;148(2):411-6. PubMed PMID: 1729361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy. AU - Blumenthal,M, AU - Marcus-Bagley,D, AU - Awdeh,Z, AU - Johnson,B, AU - Yunis,E J, AU - Alper,C A, PY - 1992/1/15/pubmed PY - 1992/1/15/medline PY - 1992/1/15/entrez SP - 411 EP - 6 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 148 IS - 2 N2 - MHC haplotypes were determined for 52 patients with ragweed pollen allergy, with and without asthma, and 27 non-atopic controls. Total IgE levels were unimodally distributed in all study groups and were higher in atopic patients in general compared with non-atopics. There was no difference in total IgE levels in patients with rhinitis only compared with those with rhinitis and asthma. IgE anti-Amb a V was detected (after subtraction of values representing the means + 2 SD of the non-atopics) in 9 of 20 asthmatics but only 3 of 32 patients with only rhinitis and was thus associated with asthma. Mean anti-Amb a V was much higher in the antibody-positive asthmatics (1710 U/ml) than in the positive patients with rhinitis only (469 U/ml). The extended MHC haplotype [HLA-B7, SC31, DR2] and its possible DR-containing fragment (SC31, DR2), were found almost exclusively among the patients with IgE anti-Amb a V and were significantly elevated in patients with asthma. DR2 in general, but not DR2 without SC31, was significantly increased in frequency in patients with anti-Amb a V. In contrast, the extended haplotype [HLA-B8, SC01, DR3] and DR3 in general were increased among patients with rhinitis only and patients without IgE anti-Amb a V compared with general controls. Thus, [HLA-B8, SC01, DR3] and DR3 appear to be "protective" for the production of this antibody and the occurrence of asthma. The findings are consistent with an MHC-linked gene or genes on [HLA-B7, SC31, DR2] (but not necessarily DR2, Dw2, or DQw6 in general) controlling the IgE immune response to Amb a V and associated with asthma in ragweed pollen-sensitive subjects. In patients with rhinitis alone and generally undetectable levels of IgE anti-Amb a V, the increase in [HLA-B8, SC01, DR3] and DR3 may mark a response to an as yet unidentified Ag associated with ragweed allergy and rhinitis only. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/1729361/HLA_DR2_[HLA_B7_SC31_DR2]_and_[HLA_B8_SC01_DR3]_haplotypes_distinguish_subjects_with_asthma_from_those_with_rhinitis_only_in_ragweed_pollen_allergy_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=1729361 DB - PRIME DP - Unbound Medicine ER -