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Binge drinking causes endothelial dysfunction, which is not prevented by wine polyphenols: a small trial in healthy volunteers.
Neth J Med. 2007 Jan; 65(1):29-35.NJ

Abstract

BACKGROUND

Binge drinking (the consumption of large quantities (>5 units) of alcohol in a short period) is associated with increased cardiovascular mortality. Wine polyphenols are considered to be protective against cardiovascular diseases. We conducted an experimental study to evaluate the acute effects of alcohol consumption on flow-mediated vasodilation and general cardiovascular parameters, using beverages with high polyphenolic content (HPC) and low polyphenolic content (LPC).

METHODS

Two groups of ten volunteers were asked to drink two different kinds of beverages. in 45 minutes, three units of red wine or an alcoholic beverage with a low polyphenolic count were consumed. Then 45 minutes were allowed for complete uptake of the alcohol or polyphenolic compounds. Next, all volunteers underwent blood pressure readings, ECG and flow-mediated vasodilation. Blood samples were taken at the same time for routine chemistry, inflammation parameters and lipids. Then the entire cycle was repeated once (in total six units of alcohol in 180 minutes).

RESULTS

No differences were found between the two drinks. Alcohol itself dose-dependently increased forearm blood flow by vasodilation of both arterioles and distribution arteries. However, flow-mediated vasodilation (FMD) for the LPC group (n=10) decreased from 7.31 +/- 4.78 (% +/- sd) to 2.82 +/- 2.9 after three drinks and 1.21 +/- 3.25 after six drinks. The FMD values for the HPC group (n=10) decreased from 8.61 +/- 1.78 to 1.78 +/- 3.71 and 1.19 +/- 2.6. There were no significant changes between the LPC and the LPC group at the three time points.

CONCLUSION

Although ethanol produces vasodilation at the level of the distribution artery as well as at an arteriolar level, it causes a decrease in flow-mediated vasodilation. This endothelial dysfunction is not corrected by the polyphenols present in wine.

Authors+Show Affiliations

Department of Internal Medicine, Meander Medical Centre, Amersfoort, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17293637

Citation

Hijmering, M L., et al. "Binge Drinking Causes Endothelial Dysfunction, Which Is Not Prevented By Wine Polyphenols: a Small Trial in Healthy Volunteers." The Netherlands Journal of Medicine, vol. 65, no. 1, 2007, pp. 29-35.
Hijmering ML, de Lange DW, Lorsheyd A, et al. Binge drinking causes endothelial dysfunction, which is not prevented by wine polyphenols: a small trial in healthy volunteers. Neth J Med. 2007;65(1):29-35.
Hijmering, M. L., de Lange, D. W., Lorsheyd, A., Kraaijenhagen, R. J., & van de Wiel, A. (2007). Binge drinking causes endothelial dysfunction, which is not prevented by wine polyphenols: a small trial in healthy volunteers. The Netherlands Journal of Medicine, 65(1), 29-35.
Hijmering ML, et al. Binge Drinking Causes Endothelial Dysfunction, Which Is Not Prevented By Wine Polyphenols: a Small Trial in Healthy Volunteers. Neth J Med. 2007;65(1):29-35. PubMed PMID: 17293637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Binge drinking causes endothelial dysfunction, which is not prevented by wine polyphenols: a small trial in healthy volunteers. AU - Hijmering,M L, AU - de Lange,D W, AU - Lorsheyd,A, AU - Kraaijenhagen,R J, AU - van de Wiel,A, PY - 2007/2/13/pubmed PY - 2007/3/28/medline PY - 2007/2/13/entrez SP - 29 EP - 35 JF - The Netherlands journal of medicine JO - Neth J Med VL - 65 IS - 1 N2 - BACKGROUND: Binge drinking (the consumption of large quantities (>5 units) of alcohol in a short period) is associated with increased cardiovascular mortality. Wine polyphenols are considered to be protective against cardiovascular diseases. We conducted an experimental study to evaluate the acute effects of alcohol consumption on flow-mediated vasodilation and general cardiovascular parameters, using beverages with high polyphenolic content (HPC) and low polyphenolic content (LPC). METHODS: Two groups of ten volunteers were asked to drink two different kinds of beverages. in 45 minutes, three units of red wine or an alcoholic beverage with a low polyphenolic count were consumed. Then 45 minutes were allowed for complete uptake of the alcohol or polyphenolic compounds. Next, all volunteers underwent blood pressure readings, ECG and flow-mediated vasodilation. Blood samples were taken at the same time for routine chemistry, inflammation parameters and lipids. Then the entire cycle was repeated once (in total six units of alcohol in 180 minutes). RESULTS: No differences were found between the two drinks. Alcohol itself dose-dependently increased forearm blood flow by vasodilation of both arterioles and distribution arteries. However, flow-mediated vasodilation (FMD) for the LPC group (n=10) decreased from 7.31 +/- 4.78 (% +/- sd) to 2.82 +/- 2.9 after three drinks and 1.21 +/- 3.25 after six drinks. The FMD values for the HPC group (n=10) decreased from 8.61 +/- 1.78 to 1.78 +/- 3.71 and 1.19 +/- 2.6. There were no significant changes between the LPC and the LPC group at the three time points. CONCLUSION: Although ethanol produces vasodilation at the level of the distribution artery as well as at an arteriolar level, it causes a decrease in flow-mediated vasodilation. This endothelial dysfunction is not corrected by the polyphenols present in wine. SN - 0300-2977 UR - https://www.unboundmedicine.com/medline/citation/17293637/Binge_drinking_causes_endothelial_dysfunction_which_is_not_prevented_by_wine_polyphenols:_a_small_trial_in_healthy_volunteers_ L2 - http://www.njmonline.nl/njm/getarticle.php?v=65&i=1&p=29 DB - PRIME DP - Unbound Medicine ER -