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Metals ions and neurodegeneration.
Biometals. 2007 Jun; 20(3-4):639-54.B

Abstract

Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying common trends underlying these neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.

Authors+Show Affiliations

Wolfson Centre for Age Related Diseases, King's College, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17294125

Citation

Molina-Holgado, Francisco, et al. "Metals Ions and Neurodegeneration." Biometals : an International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 20, no. 3-4, 2007, pp. 639-54.
Molina-Holgado F, Hider RC, Gaeta A, et al. Metals ions and neurodegeneration. Biometals. 2007;20(3-4):639-54.
Molina-Holgado, F., Hider, R. C., Gaeta, A., Williams, R., & Francis, P. (2007). Metals ions and neurodegeneration. Biometals : an International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine, 20(3-4), 639-54.
Molina-Holgado F, et al. Metals Ions and Neurodegeneration. Biometals. 2007;20(3-4):639-54. PubMed PMID: 17294125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metals ions and neurodegeneration. AU - Molina-Holgado,Francisco, AU - Hider,Robert C, AU - Gaeta,Alessandra, AU - Williams,Robert, AU - Francis,Paul, Y1 - 2007/02/09/ PY - 2006/07/03/received PY - 2006/07/20/accepted PY - 2007/2/13/pubmed PY - 2007/8/29/medline PY - 2007/2/13/entrez SP - 639 EP - 54 JF - Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine JO - Biometals VL - 20 IS - 3-4 N2 - Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying common trends underlying these neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration. SN - 0966-0844 UR - https://www.unboundmedicine.com/medline/citation/17294125/Metals_ions_and_neurodegeneration_ L2 - https://doi.org/10.1007/s10534-006-9033-z DB - PRIME DP - Unbound Medicine ER -