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Towards industrial pentose-fermenting yeast strains.
Appl Microbiol Biotechnol. 2007 Apr; 74(5):937-53.AM

Abstract

Production of bioethanol from forest and agricultural products requires a fermenting organism that converts all types of sugars in the raw material to ethanol in high yield and with a high rate. This review summarizes recent research aiming at developing industrial strains of Saccharomyces cerevisiae with the ability to ferment all lignocellulose-derived sugars. The properties required from the industrial yeast strains are discussed in relation to four benchmarks: (1) process water economy, (2) inhibitor tolerance, (3) ethanol yield, and (4) specific ethanol productivity. Of particular importance is the tolerance of the fermenting organism to fermentation inhibitors formed during fractionation/pretreatment and hydrolysis of the raw material, which necessitates the use of robust industrial strain background. While numerous metabolic engineering strategies have been developed in laboratory yeast strains, only a few approaches have been realized in industrial strains. The fermentation performance of the existing industrial pentose-fermenting S. cerevisiae strains in lignocellulose hydrolysate is reviewed. Ethanol yields of more than 0.4 g ethanol/g sugar have been achieved with several xylose-fermenting industrial strains such as TMB 3400, TMB 3006, and 424A(LNF-ST), carrying the heterologous xylose utilization pathway consisting of xylose reductase and xylitol dehydrogenase, which demonstrates the potential of pentose fermentation in improving lignocellulosic ethanol production.

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Authors+Show Affiliations

Hahn-Hägerdal B
Department of Applied Microbiology, Lund University, PO Box 124, Lund 22100, Sweden. Barbel.Hahn-Hagerdal@tmb.lth.se
Karhumaa K
No affiliation info available
Fonseca C
No affiliation info available
Spencer-Martins I
No affiliation info available
Gorwa-Grauslund MF
No affiliation info available

MeSH

FermentationForecastingIndustrial MicrobiologyPentosesSaccharomyces cerevisiae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17294186

Citation

Hahn-Hägerdal, Bärbel, et al. "Towards Industrial Pentose-fermenting Yeast Strains." Applied Microbiology and Biotechnology, vol. 74, no. 5, 2007, pp. 937-53.
Hahn-Hägerdal B, Karhumaa K, Fonseca C, et al. Towards industrial pentose-fermenting yeast strains. Appl Microbiol Biotechnol. 2007;74(5):937-53.
Hahn-Hägerdal, B., Karhumaa, K., Fonseca, C., Spencer-Martins, I., & Gorwa-Grauslund, M. F. (2007). Towards industrial pentose-fermenting yeast strains. Applied Microbiology and Biotechnology, 74(5), 937-53.
Hahn-Hägerdal B, et al. Towards Industrial Pentose-fermenting Yeast Strains. Appl Microbiol Biotechnol. 2007;74(5):937-53. PubMed PMID: 17294186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Towards industrial pentose-fermenting yeast strains. AU - Hahn-Hägerdal,Bärbel, AU - Karhumaa,Kaisa, AU - Fonseca,César, AU - Spencer-Martins,Isabel, AU - Gorwa-Grauslund,Marie F, Y1 - 2007/02/09/ PY - 2006/10/19/received PY - 2006/12/25/accepted PY - 2006/12/21/revised PY - 2007/2/13/pubmed PY - 2007/9/29/medline PY - 2007/2/13/entrez SP - 937 EP - 53 JF - Applied microbiology and biotechnology JO - Appl Microbiol Biotechnol VL - 74 IS - 5 N2 - Production of bioethanol from forest and agricultural products requires a fermenting organism that converts all types of sugars in the raw material to ethanol in high yield and with a high rate. This review summarizes recent research aiming at developing industrial strains of Saccharomyces cerevisiae with the ability to ferment all lignocellulose-derived sugars. The properties required from the industrial yeast strains are discussed in relation to four benchmarks: (1) process water economy, (2) inhibitor tolerance, (3) ethanol yield, and (4) specific ethanol productivity. Of particular importance is the tolerance of the fermenting organism to fermentation inhibitors formed during fractionation/pretreatment and hydrolysis of the raw material, which necessitates the use of robust industrial strain background. While numerous metabolic engineering strategies have been developed in laboratory yeast strains, only a few approaches have been realized in industrial strains. The fermentation performance of the existing industrial pentose-fermenting S. cerevisiae strains in lignocellulose hydrolysate is reviewed. Ethanol yields of more than 0.4 g ethanol/g sugar have been achieved with several xylose-fermenting industrial strains such as TMB 3400, TMB 3006, and 424A(LNF-ST), carrying the heterologous xylose utilization pathway consisting of xylose reductase and xylitol dehydrogenase, which demonstrates the potential of pentose fermentation in improving lignocellulosic ethanol production. SN - 0175-7598 UR - https://www.unboundmedicine.com/medline/citation/17294186/Towards_industrial_pentose_fermenting_yeast_strains_ L2 - https://dx.doi.org/10.1007/s00253-006-0827-2 DB - PRIME DP - Unbound Medicine ER -