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Inflammation as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis in haemodialysis patients: the role of chlamydia and cytomegalovirus infection.
Nephrology (Carlton) 2007; 12(1):25-32N

Abstract

OBJECTIVES

Atherosclerotic vascular disease is the most frequent complication seen in haemodialysis (HD) patients. Evidence suggests that inflammation may play a role in the pathogenesis and progression of atherosclerosis. Our aim was to evaluate the causative role of inflammation in atherosclerosis among HD patients.

METHODS

Intima-media thickness (IMT) in carotid arteries was determined in 54 HD patients and 52 controls. Plasma levels of lipids, glucose, albumin and several acute phase proteins, and immunoglobulin G titres against chlamydia and cytomegalovirus were measured in all subjects.

RESULTS

Mean carotid IMT was significantly greater in HD patients than in controls (0.75 mm vs 0.56 mm, P < 0.005). While plasma levels of C-reactive protein (CRP), serum amyloid A (SAA), lipoprotein (a) Lp(a), fibrinogen and ferritin were higher in HD patients, albumin levels were lower. In HD patients, carotid IMT was correlated positively with CRP (R = 0.29, P = 0.019), SAA (R = 0.69, P < 0.001), Lp(a) (R = 0.42, P = 0.001), fibrinogen (R = 0.57, P < 0.001) and chlamydia pneumonia immunoglobulin G titres (R = 0.50, P < 0.001), and negatively with albumin levels (R = -0.33, P = 0.02); there was no relationship between carotid IMT and hypertension, plasma lipid levels and cytomegalovirus. In multivariate regression analysis, these variables still showed a significant relationship with IMT (R(2) = 0.694 and P < 0.001).

CONCLUSION

We conclude that atherosclerotic changes are more common in HD patients than in controls, and that inflammatory processes may play a role in the pathogenesis of atherosclerosis.

Authors+Show Affiliations

Division of Nephrology, Faculty of Medicine, Gaziantep University, Turkey. buyukhatip@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17295657

Citation

Buyukhatipoglu, Hakan, et al. "Inflammation as a Risk Factor for Carotid Intimal-medial Thickening, a Measure of Subclinical Atherosclerosis in Haemodialysis Patients: the Role of Chlamydia and Cytomegalovirus Infection." Nephrology (Carlton, Vic.), vol. 12, no. 1, 2007, pp. 25-32.
Buyukhatipoglu H, Tiryaki O, Tahta K, et al. Inflammation as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis in haemodialysis patients: the role of chlamydia and cytomegalovirus infection. Nephrology (Carlton). 2007;12(1):25-32.
Buyukhatipoglu, H., Tiryaki, O., Tahta, K., & Usalan, C. (2007). Inflammation as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis in haemodialysis patients: the role of chlamydia and cytomegalovirus infection. Nephrology (Carlton, Vic.), 12(1), pp. 25-32.
Buyukhatipoglu H, et al. Inflammation as a Risk Factor for Carotid Intimal-medial Thickening, a Measure of Subclinical Atherosclerosis in Haemodialysis Patients: the Role of Chlamydia and Cytomegalovirus Infection. Nephrology (Carlton). 2007;12(1):25-32. PubMed PMID: 17295657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammation as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis in haemodialysis patients: the role of chlamydia and cytomegalovirus infection. AU - Buyukhatipoglu,Hakan, AU - Tiryaki,Ozlem, AU - Tahta,Kadir, AU - Usalan,Celalettin, PY - 2007/2/14/pubmed PY - 2007/4/24/medline PY - 2007/2/14/entrez SP - 25 EP - 32 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 12 IS - 1 N2 - OBJECTIVES: Atherosclerotic vascular disease is the most frequent complication seen in haemodialysis (HD) patients. Evidence suggests that inflammation may play a role in the pathogenesis and progression of atherosclerosis. Our aim was to evaluate the causative role of inflammation in atherosclerosis among HD patients. METHODS: Intima-media thickness (IMT) in carotid arteries was determined in 54 HD patients and 52 controls. Plasma levels of lipids, glucose, albumin and several acute phase proteins, and immunoglobulin G titres against chlamydia and cytomegalovirus were measured in all subjects. RESULTS: Mean carotid IMT was significantly greater in HD patients than in controls (0.75 mm vs 0.56 mm, P < 0.005). While plasma levels of C-reactive protein (CRP), serum amyloid A (SAA), lipoprotein (a) Lp(a), fibrinogen and ferritin were higher in HD patients, albumin levels were lower. In HD patients, carotid IMT was correlated positively with CRP (R = 0.29, P = 0.019), SAA (R = 0.69, P < 0.001), Lp(a) (R = 0.42, P = 0.001), fibrinogen (R = 0.57, P < 0.001) and chlamydia pneumonia immunoglobulin G titres (R = 0.50, P < 0.001), and negatively with albumin levels (R = -0.33, P = 0.02); there was no relationship between carotid IMT and hypertension, plasma lipid levels and cytomegalovirus. In multivariate regression analysis, these variables still showed a significant relationship with IMT (R(2) = 0.694 and P < 0.001). CONCLUSION: We conclude that atherosclerotic changes are more common in HD patients than in controls, and that inflammatory processes may play a role in the pathogenesis of atherosclerosis. SN - 1320-5358 UR - https://www.unboundmedicine.com/medline/citation/17295657/Inflammation_as_a_risk_factor_for_carotid_intimal_medial_thickening_a_measure_of_subclinical_atherosclerosis_in_haemodialysis_patients:_the_role_of_chlamydia_and_cytomegalovirus_infection_ L2 - https://doi.org/10.1111/j.1440-1797.2006.00742.x DB - PRIME DP - Unbound Medicine ER -