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Mesenchymal stem cells: immunobiology and therapeutic potential in kidney disease.
Nephrology (Carlton). 2007 Feb; 12(1):44-52.N

Abstract

Mesenchymal stem cells (MSC) are non-haematopoietic cells that are prevalent in the adult bone marrow but can also be isolated from a variety of other postnatal tissues. MSC are non-immunogenic and are immunosuppressive, with the ability to inhibit maturation of dendritic cells and suppress the function of naïve and memory T cells, B cells and NK cells. In addition to their immunomodulatory properties, MSC are capable of differentiating into various tissues of mesenchymal and non-mesenchymal origin and migrating to sites of tissue injury and inflammation to participate in tissue repair. A number of studies in animal models of cardiac injury, stroke and ischaemic renal injury have demonstrated the clinical potential of MSC in tissue regeneration and repair. MSC are currently being evaluated in various preclinical and clinical studies in humans and offer significant potential as a novel cellular therapy for tissue regeneration and immunological conditions. The present review focuses on the unique immunomodulatory and regenerative properties of MSC and their potential role in the treatment of kidney disease.

Authors+Show Affiliations

Queensland Child & Adolescent Renal Service, Royal Children's Hospital, Australia. Steven_McTaggart@health.qld.gov.auNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17295660

Citation

McTaggart, Steven J., and Kerry Atkinson. "Mesenchymal Stem Cells: Immunobiology and Therapeutic Potential in Kidney Disease." Nephrology (Carlton, Vic.), vol. 12, no. 1, 2007, pp. 44-52.
McTaggart SJ, Atkinson K. Mesenchymal stem cells: immunobiology and therapeutic potential in kidney disease. Nephrology (Carlton). 2007;12(1):44-52.
McTaggart, S. J., & Atkinson, K. (2007). Mesenchymal stem cells: immunobiology and therapeutic potential in kidney disease. Nephrology (Carlton, Vic.), 12(1), 44-52.
McTaggart SJ, Atkinson K. Mesenchymal Stem Cells: Immunobiology and Therapeutic Potential in Kidney Disease. Nephrology (Carlton). 2007;12(1):44-52. PubMed PMID: 17295660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal stem cells: immunobiology and therapeutic potential in kidney disease. AU - McTaggart,Steven J, AU - Atkinson,Kerry, PY - 2007/2/14/pubmed PY - 2007/4/24/medline PY - 2007/2/14/entrez SP - 44 EP - 52 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 12 IS - 1 N2 - Mesenchymal stem cells (MSC) are non-haematopoietic cells that are prevalent in the adult bone marrow but can also be isolated from a variety of other postnatal tissues. MSC are non-immunogenic and are immunosuppressive, with the ability to inhibit maturation of dendritic cells and suppress the function of naïve and memory T cells, B cells and NK cells. In addition to their immunomodulatory properties, MSC are capable of differentiating into various tissues of mesenchymal and non-mesenchymal origin and migrating to sites of tissue injury and inflammation to participate in tissue repair. A number of studies in animal models of cardiac injury, stroke and ischaemic renal injury have demonstrated the clinical potential of MSC in tissue regeneration and repair. MSC are currently being evaluated in various preclinical and clinical studies in humans and offer significant potential as a novel cellular therapy for tissue regeneration and immunological conditions. The present review focuses on the unique immunomodulatory and regenerative properties of MSC and their potential role in the treatment of kidney disease. SN - 1320-5358 UR - https://www.unboundmedicine.com/medline/citation/17295660/Mesenchymal_stem_cells:_immunobiology_and_therapeutic_potential_in_kidney_disease_ L2 - https://doi.org/10.1111/j.1440-1797.2006.00753.x DB - PRIME DP - Unbound Medicine ER -