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The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis.

Abstract

Food is closely associated with the pathogenesis of atopic dermatitis. Food allergy is usually mediated by IgE antibody to specific food proteins and determination of specific IgE antibody is the basis of the common diagnostic test for food allergy. IgG4 have been reported as blocking antibody and the protective effects of blocking antibody may be clear in inhalant allergy. However, the role of IgG4 in food allergy is still a matter of debate. In this study, the clinical significance of food allergen-specific IgE/IgG4 in atopic dermatitis was investigated and compared with that of IgE. A total of 97 patients who fulfilled the diagnostic criteria for atopic dermatitis participated in this study. Skin prick test and allergy patch test were performed. Specific IgE and IgG4 concentration were measured using allergy protein chip, 'AllergyChip'. Double blinded placebo controlled food challenge test (DBPCFC) was performed for the diagnosis of allergy to milk, egg white, wheat, and soybean. DBPCFCs for milk, egg white, soybean, and wheat were performed. The positive rates were 31.7% (19/60) in milk, 36.7% (18/49) in egg white, 30.4% (7/23) in soybean, and 34.8% (8/23) in wheat. Mean IgE/IgG4 levels in DBPCFC (+) subjects is higher than those in DBPCFC (-) subjects in all food items studied. Of them, there were significantly different between two groups in egg white and wheat (Egg white in DBPCFC (+) vs. (-): 0.4 +/- 0.3 vs. 0.2 +/- 0.2, wheat in DBPCFC (+) vs. (-): 1.2 +/- 1.2 vs. 0.3 +/- 0.3, p < 0.05). Allergen-specific IgE/IgG4 may provide one of the clues to understand the mechanism of food allergy in atopic dermatitis. The present study suggests that protein microarray can be one of the useful methods to assess ongoing status of allergic diseases.

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  • Authors+Show Affiliations

    ,

    Department of Allergy and Clinical Immunology, Seoul Allergy Clinic, Seoul, Korea.

    , , ,

    Source

    MeSH

    Adolescent
    Adult
    Allergens
    Child
    Child, Preschool
    Dermatitis, Atopic
    Double-Blind Method
    Female
    Food Hypersensitivity
    Humans
    Immunoglobulin E
    Immunoglobulin G
    Male
    Protein Array Analysis
    Skin Tests

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17295801

    Citation

    Noh, Geunwoong, et al. "The Clinical Significance of Food Specific IgE/IgG4 in Food Specific Atopic Dermatitis." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 18, no. 1, 2007, pp. 63-70.
    Noh G, Ahn HS, Cho NY, et al. The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. Pediatr Allergy Immunol. 2007;18(1):63-70.
    Noh, G., Ahn, H. S., Cho, N. Y., Lee, S., & Oh, J. W. (2007). The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 18(1), pp. 63-70.
    Noh G, et al. The Clinical Significance of Food Specific IgE/IgG4 in Food Specific Atopic Dermatitis. Pediatr Allergy Immunol. 2007;18(1):63-70. PubMed PMID: 17295801.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. AU - Noh,Geunwoong, AU - Ahn,Hyun-Sook, AU - Cho,Nam-Yun, AU - Lee,Sangsun, AU - Oh,Jae-Won, PY - 2007/2/14/pubmed PY - 2007/5/23/medline PY - 2007/2/14/entrez SP - 63 EP - 70 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 18 IS - 1 N2 - Food is closely associated with the pathogenesis of atopic dermatitis. Food allergy is usually mediated by IgE antibody to specific food proteins and determination of specific IgE antibody is the basis of the common diagnostic test for food allergy. IgG4 have been reported as blocking antibody and the protective effects of blocking antibody may be clear in inhalant allergy. However, the role of IgG4 in food allergy is still a matter of debate. In this study, the clinical significance of food allergen-specific IgE/IgG4 in atopic dermatitis was investigated and compared with that of IgE. A total of 97 patients who fulfilled the diagnostic criteria for atopic dermatitis participated in this study. Skin prick test and allergy patch test were performed. Specific IgE and IgG4 concentration were measured using allergy protein chip, 'AllergyChip'. Double blinded placebo controlled food challenge test (DBPCFC) was performed for the diagnosis of allergy to milk, egg white, wheat, and soybean. DBPCFCs for milk, egg white, soybean, and wheat were performed. The positive rates were 31.7% (19/60) in milk, 36.7% (18/49) in egg white, 30.4% (7/23) in soybean, and 34.8% (8/23) in wheat. Mean IgE/IgG4 levels in DBPCFC (+) subjects is higher than those in DBPCFC (-) subjects in all food items studied. Of them, there were significantly different between two groups in egg white and wheat (Egg white in DBPCFC (+) vs. (-): 0.4 +/- 0.3 vs. 0.2 +/- 0.2, wheat in DBPCFC (+) vs. (-): 1.2 +/- 1.2 vs. 0.3 +/- 0.3, p < 0.05). Allergen-specific IgE/IgG4 may provide one of the clues to understand the mechanism of food allergy in atopic dermatitis. The present study suggests that protein microarray can be one of the useful methods to assess ongoing status of allergic diseases. SN - 0905-6157 UR - https://www.unboundmedicine.com/medline/citation/17295801/The_clinical_significance_of_food_specific_IgE/IgG4_in_food_specific_atopic_dermatitis_ L2 - https://doi.org/10.1111/j.1399-3038.2006.00478.x DB - PRIME DP - Unbound Medicine ER -