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Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition.
Cancer Causes Control 2007; 18(4):399-413CC

Abstract

OBJECTIVE

To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups.

METHODS

Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling.

RESULTS

Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m(2)) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI > or = 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of > or =88 cm vs. <80 cm was 1.76, 95% CI = 1.42-2.19. Adult weight gain of > or =20 kg compared with stable weight (+/-3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11-2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users.

CONCLUSION

Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy.

Authors+Show Affiliations

Division of Population Health and Information, Alberta Cancer Board, T2N 4N2, Calgary, Alberta, Canada. chrisf@cancerboard.ab.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17297555

Citation

Friedenreich, Christine, et al. "Anthropometric Factors and Risk of Endometrial Cancer: the European Prospective Investigation Into Cancer and Nutrition." Cancer Causes & Control : CCC, vol. 18, no. 4, 2007, pp. 399-413.
Friedenreich C, Cust A, Lahmann PH, et al. Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition. Cancer Causes Control. 2007;18(4):399-413.
Friedenreich, C., Cust, A., Lahmann, P. H., Steindorf, K., Boutron-Ruault, M. C., Clavel-Chapelon, F., ... Riboli, E. (2007). Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition. Cancer Causes & Control : CCC, 18(4), pp. 399-413.
Friedenreich C, et al. Anthropometric Factors and Risk of Endometrial Cancer: the European Prospective Investigation Into Cancer and Nutrition. Cancer Causes Control. 2007;18(4):399-413. PubMed PMID: 17297555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition. AU - Friedenreich,Christine, AU - Cust,Anne, AU - Lahmann,Petra H, AU - Steindorf,Karen, AU - Boutron-Ruault,Marie-Christine, AU - Clavel-Chapelon,Françoise, AU - Mesrine,Sylvie, AU - Linseisen,Jakob, AU - Rohrmann,Sabine, AU - Boeing,Heiner, AU - Pischon,Tobias, AU - Tjønneland,Anne, AU - Halkjaer,Jytte, AU - Overvad,Kim, AU - Mendez,Michelle, AU - Redondo,M L, AU - Garcia,Carmen Martinez, AU - Larrañaga,Nerea, AU - Tormo,María-José, AU - Gurrea,Aurelio Barricarte, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Allen,Naomi, AU - Key,Tim, AU - Trichopoulou,Antonia, AU - Vasilopoulou,Effie, AU - Trichopoulos,Dimitrios, AU - Pala,Valeria, AU - Palli,Domenico, AU - Tumino,Rosario, AU - Mattiello,Amalia, AU - Vineis,Paolo, AU - Bueno-de-Mesquita,H Bas, AU - Peeters,Petra H M, AU - Berglund,Göran, AU - Manjer,Jonas, AU - Lundin,Eva, AU - Lukanova,Annekatrin, AU - Slimani,Nadia, AU - Jenab,Mazda, AU - Kaaks,Rudolf, AU - Riboli,Elio, Y1 - 2007/02/12/ PY - 2006/10/04/received PY - 2006/12/21/accepted PY - 2007/2/14/pubmed PY - 2007/6/8/medline PY - 2007/2/14/entrez SP - 399 EP - 413 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 18 IS - 4 N2 - OBJECTIVE: To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups. METHODS: Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling. RESULTS: Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m(2)) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI > or = 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of > or =88 cm vs. <80 cm was 1.76, 95% CI = 1.42-2.19. Adult weight gain of > or =20 kg compared with stable weight (+/-3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11-2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users. CONCLUSION: Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17297555/Anthropometric_factors_and_risk_of_endometrial_cancer:_the_European_prospective_investigation_into_cancer_and_nutrition_ L2 - https://doi.org/10.1007/s10552-006-0113-8 DB - PRIME DP - Unbound Medicine ER -