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[Production of alpha-, beta-, and lambda-interferons by epithelial and mononuclear cells during acute respiratory viral infection].
Zh Mikrobiol Epidemiol Immunobiol 2006 Nov-Dec; (7):63-9ZM

Abstract

Role of several types of cells (human broncho-epithelial cells, BEAS-2B cell line, and mononuclear cells as model of macrophages) in production of alpha-, beta- and lambda-interferons during acute respiratory viral infection was studied. Kits for detection of these interferons by quantitative PCR assay has been developed. In human broncho-epithelial cells respiratory viruses induced statistically significant expression of alpha-interferon mRNA at 8 hours after infection, beta-interferon mRNA--at 24 hours after infection, IL-29 mRNA (lambda-interferon) - at 24 hours after infection, IL-28 mRNA (lambda-interferon) - at 8 and 24 hours after infection. In BEAS-2B cell line induction of alpha-interferon mRNA expression was observed at 8 hours after infection, beta-interferon mRNA expression - at 24 hours after infection, IL-29 mRNA (lambda-interferon) expression - at 8 and 24 hours after viral challenge. Production of beta- and lambda-interferons by ELISA at 24 hours after infection has been detected. When polymorphonuclear cells were challenged, induction of alpha-, beta-, and lambda-interferons expression was observed at 8 hours after infection. Production of alpha-, beta- and lambda-interferons has been detected by ELISA at 24 hours after infection by rhinovirus 16.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

17297883

Citation

Khaitov, M R., et al. "[Production of Alpha-, Beta-, and Lambda-interferons By Epithelial and Mononuclear Cells During Acute Respiratory Viral Infection]." Zhurnal Mikrobiologii, Epidemiologii, I Immunobiologii, 2006, pp. 63-9.
Khaitov MR, Laza-Stantca V, Edwards MR, et al. [Production of alpha-, beta-, and lambda-interferons by epithelial and mononuclear cells during acute respiratory viral infection]. Zh Mikrobiol Epidemiol Immunobiol. 2006.
Khaitov, M. R., Laza-Stantca, V., Edwards, M. R., & Johnston, S. L. (2006). [Production of alpha-, beta-, and lambda-interferons by epithelial and mononuclear cells during acute respiratory viral infection]. Zhurnal Mikrobiologii, Epidemiologii, I Immunobiologii, (7), pp. 63-9.
Khaitov MR, et al. [Production of Alpha-, Beta-, and Lambda-interferons By Epithelial and Mononuclear Cells During Acute Respiratory Viral Infection]. Zh Mikrobiol Epidemiol Immunobiol. 2006;(7)63-9. PubMed PMID: 17297883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Production of alpha-, beta-, and lambda-interferons by epithelial and mononuclear cells during acute respiratory viral infection]. AU - Khaitov,M R, AU - Laza-Stantca,V, AU - Edwards,M R, AU - Johnston,S L, PY - 2007/2/15/pubmed PY - 2007/3/23/medline PY - 2007/2/15/entrez SP - 63 EP - 9 JF - Zhurnal mikrobiologii, epidemiologii, i immunobiologii JO - Zh. Mikrobiol. Epidemiol. Immunobiol. IS - 7 N2 - Role of several types of cells (human broncho-epithelial cells, BEAS-2B cell line, and mononuclear cells as model of macrophages) in production of alpha-, beta- and lambda-interferons during acute respiratory viral infection was studied. Kits for detection of these interferons by quantitative PCR assay has been developed. In human broncho-epithelial cells respiratory viruses induced statistically significant expression of alpha-interferon mRNA at 8 hours after infection, beta-interferon mRNA--at 24 hours after infection, IL-29 mRNA (lambda-interferon) - at 24 hours after infection, IL-28 mRNA (lambda-interferon) - at 8 and 24 hours after infection. In BEAS-2B cell line induction of alpha-interferon mRNA expression was observed at 8 hours after infection, beta-interferon mRNA expression - at 24 hours after infection, IL-29 mRNA (lambda-interferon) expression - at 8 and 24 hours after viral challenge. Production of beta- and lambda-interferons by ELISA at 24 hours after infection has been detected. When polymorphonuclear cells were challenged, induction of alpha-, beta-, and lambda-interferons expression was observed at 8 hours after infection. Production of alpha-, beta- and lambda-interferons has been detected by ELISA at 24 hours after infection by rhinovirus 16. SN - 0372-9311 UR - https://www.unboundmedicine.com/medline/citation/17297883/[Production_of_alpha__beta__and_lambda_interferons_by_epithelial_and_mononuclear_cells_during_acute_respiratory_viral_infection]_ DB - PRIME DP - Unbound Medicine ER -