Tags

Type your tag names separated by a space and hit enter

Epidemiology, clinical characteristics and antimicrobial resistance patterns of community-acquired pneumonia in 1702 hospitalized children in Singapore.
Respirology. 2007 Mar; 12(2):254-61.R

Abstract

OBJECTIVE AND BACKGROUND

Childhood community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality worldwide. The features of childhood CAP vary between countries. The aim of this study was to delineate the clinical characteristics, complications, spectrum of pathogens and patterns of antimicrobial resistance associated with hospitalized cases of childhood CAP in Singapore.

METHODS

A retrospective study was conducted of patients discharged from Singapore's only children's hospital over a 3-year period with a principal diagnosis of CAP.

RESULTS

A total of 1702 children, with a median age of 4.2 years (range: 1 month-16.3 years) were enrolled. A pathogen was identifiable in 38.4% of cases, including Mycoplasma pneumoniae in 20.3%, typical respiratory bacteria in 10.3% (64.6%Streptococcus pneumoniae; 21.7% non-typeable Haemophilus influenzae), viruses in 5.5% and mixed bacterial/viral infections in 2%. The majority of M. pneumoniae infections were in school-aged children (>5 years). Severity of infection was greater in CAP caused by typical bacteria, as reflected by length of hospital stay, CRP level, white cell and absolute neutrophil counts. Mortality from typical bacterial infections (8.9%) exceeded that from M. pneumoniae (0.3%) and viral pneumonias (0%) (P < 0.001). Aminopenicillins were often prescribed empirically for suspected S. pneumoniae and H. influenzae infections; however, resistance to these agents was frequently documented among S. pneumoniae (58.5%) and H. influenzae isolates (51%).

CONCLUSION

In Singaporean children hospitalized with CAP, M. pneumoniae is the most commonly identified causative organism, followed by common respiratory viruses, S. pneumoniae and H. influenzae. Streptococcus pneumoniae and H. influenzae are associated with greater severity of infection than other organisms, and have high levels of resistance to commonly prescribed antibiotics.

Authors+Show Affiliations

Department of Respiratory Medicine, Kandang Kerbau Children's Hospital, Singapore. chiang.wen.chin@kkh.com.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17298459

Citation

Chiang, Wen C., et al. "Epidemiology, Clinical Characteristics and Antimicrobial Resistance Patterns of Community-acquired Pneumonia in 1702 Hospitalized Children in Singapore." Respirology (Carlton, Vic.), vol. 12, no. 2, 2007, pp. 254-61.
Chiang WC, Teoh OH, Chong CY, et al. Epidemiology, clinical characteristics and antimicrobial resistance patterns of community-acquired pneumonia in 1702 hospitalized children in Singapore. Respirology. 2007;12(2):254-61.
Chiang, W. C., Teoh, O. H., Chong, C. Y., Goh, A., Tang, J. P., & Chay, O. M. (2007). Epidemiology, clinical characteristics and antimicrobial resistance patterns of community-acquired pneumonia in 1702 hospitalized children in Singapore. Respirology (Carlton, Vic.), 12(2), 254-61.
Chiang WC, et al. Epidemiology, Clinical Characteristics and Antimicrobial Resistance Patterns of Community-acquired Pneumonia in 1702 Hospitalized Children in Singapore. Respirology. 2007;12(2):254-61. PubMed PMID: 17298459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology, clinical characteristics and antimicrobial resistance patterns of community-acquired pneumonia in 1702 hospitalized children in Singapore. AU - Chiang,Wen C, AU - Teoh,Oon H, AU - Chong,Chia Y, AU - Goh,Anne, AU - Tang,Jenny P L, AU - Chay,Oh M, PY - 2007/2/15/pubmed PY - 2007/4/14/medline PY - 2007/2/15/entrez SP - 254 EP - 61 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 12 IS - 2 N2 - OBJECTIVE AND BACKGROUND: Childhood community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality worldwide. The features of childhood CAP vary between countries. The aim of this study was to delineate the clinical characteristics, complications, spectrum of pathogens and patterns of antimicrobial resistance associated with hospitalized cases of childhood CAP in Singapore. METHODS: A retrospective study was conducted of patients discharged from Singapore's only children's hospital over a 3-year period with a principal diagnosis of CAP. RESULTS: A total of 1702 children, with a median age of 4.2 years (range: 1 month-16.3 years) were enrolled. A pathogen was identifiable in 38.4% of cases, including Mycoplasma pneumoniae in 20.3%, typical respiratory bacteria in 10.3% (64.6%Streptococcus pneumoniae; 21.7% non-typeable Haemophilus influenzae), viruses in 5.5% and mixed bacterial/viral infections in 2%. The majority of M. pneumoniae infections were in school-aged children (>5 years). Severity of infection was greater in CAP caused by typical bacteria, as reflected by length of hospital stay, CRP level, white cell and absolute neutrophil counts. Mortality from typical bacterial infections (8.9%) exceeded that from M. pneumoniae (0.3%) and viral pneumonias (0%) (P < 0.001). Aminopenicillins were often prescribed empirically for suspected S. pneumoniae and H. influenzae infections; however, resistance to these agents was frequently documented among S. pneumoniae (58.5%) and H. influenzae isolates (51%). CONCLUSION: In Singaporean children hospitalized with CAP, M. pneumoniae is the most commonly identified causative organism, followed by common respiratory viruses, S. pneumoniae and H. influenzae. Streptococcus pneumoniae and H. influenzae are associated with greater severity of infection than other organisms, and have high levels of resistance to commonly prescribed antibiotics. SN - 1323-7799 UR - https://www.unboundmedicine.com/medline/citation/17298459/Epidemiology_clinical_characteristics_and_antimicrobial_resistance_patterns_of_community_acquired_pneumonia_in_1702_hospitalized_children_in_Singapore_ L2 - https://doi.org/10.1111/j.1440-1843.2006.01036.x DB - PRIME DP - Unbound Medicine ER -