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Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women.
Br J Nutr 2007; 97(2):373-80BJ

Abstract

While current intakes of phylloquinone (vitamin K1) in many populations are believed to be sufficient to maintain normal blood coagulation, these may be insufficient to cover the requirements for optimal bone metabolism. Therefore, the objective of the present study was to investigate the effect of increasing phylloquinone intakes above the usual dietary intake for 6 weeks on biochemical markers of vitamin K status and bone turnover in postmenopausal women. Thirty-one postmenopausal women completed this 3 x 6-week randomised cross-over study, in which volunteers were supplemented with 0 (placebo), 200, and 500 microg phylloquinone/d. In addition, the volunteers were given 10 microg vitamin D3/d throughout the study period. With increasing phylloquinone intake, the concentration of serum gamma-carboxylated and under-gamma-carboxylated osteocalcin was significantly increased and decreased, respectively, in a dose-dependent manner (P < 0.001). Mean serum phylloquinone concentration was significantly (P < 0.001) higher with daily supplementation with 500 microg phylloquinone/d compared with that during either of the placebo or 200 microg phylloquinone/d supplementation periods, which did not differ (P = 0.15). Serum total osteocalcin was significantly (P < 0.001) increased in response to daily supplementation with 500 (but not 200) microg phylloquinone compared with placebo. Serum bone-specific alkaline phosphatase as well as the urinary markers of bone resorption (N-telopeptide cross-links of collagen, pyridinoline and deoxypyridinoline) and urinary gamma-carboxyglutamate were unaffected by phylloquinone supplementation. In conclusion, while daily supplementation with 200 and 500 microg phylloquinone/d for 6 weeks increased vitamin K status in postmenopausal women, it had no effect on bone turnover.

Authors+Show Affiliations

Department of Human Nutrition/Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark. shb@kvl.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17298708

Citation

Bügel, Susanne, et al. "Effect of Phylloquinone Supplementation On Biochemical Markers of Vitamin K Status and Bone Turnover in Postmenopausal Women." The British Journal of Nutrition, vol. 97, no. 2, 2007, pp. 373-80.
Bügel S, Sørensen AD, Hels O, et al. Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. Br J Nutr. 2007;97(2):373-80.
Bügel, S., Sørensen, A. D., Hels, O., Kristensen, M., Vermeer, C., Jakobsen, J., ... Cashman, K. D. (2007). Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. The British Journal of Nutrition, 97(2), pp. 373-80.
Bügel S, et al. Effect of Phylloquinone Supplementation On Biochemical Markers of Vitamin K Status and Bone Turnover in Postmenopausal Women. Br J Nutr. 2007;97(2):373-80. PubMed PMID: 17298708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. AU - Bügel,Susanne, AU - Sørensen,A Dorthe, AU - Hels,Ole, AU - Kristensen,Mette, AU - Vermeer,Cees, AU - Jakobsen,Jette, AU - Flynn,Albert, AU - Mølgaard,Christian, AU - Cashman,Kevin D, PY - 2007/2/15/pubmed PY - 2007/6/20/medline PY - 2007/2/15/entrez SP - 373 EP - 80 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 97 IS - 2 N2 - While current intakes of phylloquinone (vitamin K1) in many populations are believed to be sufficient to maintain normal blood coagulation, these may be insufficient to cover the requirements for optimal bone metabolism. Therefore, the objective of the present study was to investigate the effect of increasing phylloquinone intakes above the usual dietary intake for 6 weeks on biochemical markers of vitamin K status and bone turnover in postmenopausal women. Thirty-one postmenopausal women completed this 3 x 6-week randomised cross-over study, in which volunteers were supplemented with 0 (placebo), 200, and 500 microg phylloquinone/d. In addition, the volunteers were given 10 microg vitamin D3/d throughout the study period. With increasing phylloquinone intake, the concentration of serum gamma-carboxylated and under-gamma-carboxylated osteocalcin was significantly increased and decreased, respectively, in a dose-dependent manner (P < 0.001). Mean serum phylloquinone concentration was significantly (P < 0.001) higher with daily supplementation with 500 microg phylloquinone/d compared with that during either of the placebo or 200 microg phylloquinone/d supplementation periods, which did not differ (P = 0.15). Serum total osteocalcin was significantly (P < 0.001) increased in response to daily supplementation with 500 (but not 200) microg phylloquinone compared with placebo. Serum bone-specific alkaline phosphatase as well as the urinary markers of bone resorption (N-telopeptide cross-links of collagen, pyridinoline and deoxypyridinoline) and urinary gamma-carboxyglutamate were unaffected by phylloquinone supplementation. In conclusion, while daily supplementation with 200 and 500 microg phylloquinone/d for 6 weeks increased vitamin K status in postmenopausal women, it had no effect on bone turnover. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17298708/Effect_of_phylloquinone_supplementation_on_biochemical_markers_of_vitamin_K_status_and_bone_turnover_in_postmenopausal_women_ L2 - https://www.cambridge.org/core/product/identifier/S000711450715460X/type/journal_article DB - PRIME DP - Unbound Medicine ER -