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Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women.
Br J Nutr. 2007 Feb; 97(2):405-10.BJ

Abstract

The aim of this study was to determine after 52 weeks whether advice to follow a lower carbohydrate diet, either high in monounsaturated fat or low fat, high in protein had differential effects in a free-living community setting. Following weight loss on either a high monounsaturated fat, standard protein (HMF; 50 % fat, 20 % protein (67 g/d), 30 % carbohydrate) or a high protein, moderate fat (HP) (40 % protein (136 g/d), 30 % fat, 30 % carbohydrate) energy-restricted diet (6000 kJ/d) subjects were asked to maintain the same dietary pattern without intensive dietary counselling for the following 36 weeks. Overall weight loss was 6.2 (SD 7.3) kg (P < 0.01 for time with no diet effect, 7.6 (SD 8.1) kg, HMF v. 4.8 (SD 6.6) kg, HP). In a multivariate regression model predictors of weight loss at the end of the study were sex, age and reported percentage energy from protein (R2 0.22, P < 0.05 for the whole model). Fasting plasma insulin decreased (P < 0.01, with no difference between diets), 13.9 (SD 4.6) to 10.2 (SD 5.2) mIU/l, but fasting plasma glucose was not reduced. Neither total cholesterol nor LDL-cholesterol were different but HDL was higher, 1.19 (SD 0.26) v. 1.04 (SD 0.29) (P < 0.001 for time, no diet effect), while TAG was lower, 1.87 (SD 1.23) v. 2.22 (SD 1.15) mmol/l (P < 0.05 for time, no diet effect). C-reactive protein decreased (3.97 (SD 2.84) to 2.43 (SD 2.29) mg/l, P < 0.01). Food records showed that compliance to the prescribed dietary patterns was poor. After 1 year there remained a clinically significant weight loss and improvement in cardiovascular risk factors with no adverse effects of a high monounsaturated fat diet.

Authors+Show Affiliations

CSIRO Human Nutrition, Adelaide, South Australia, 5000, Australia. jennifer.keogh@csiro.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17298712

Citation

Keogh, Jennifer B., et al. "Long-term Weight Maintenance and Cardiovascular Risk Factors Are Not Different Following Weight Loss On Carbohydrate-restricted Diets High in Either Monounsaturated Fat or Protein in Obese Hyperinsulinaemic Men and Women." The British Journal of Nutrition, vol. 97, no. 2, 2007, pp. 405-10.
Keogh JB, Luscombe-Marsh ND, Noakes M, et al. Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women. Br J Nutr. 2007;97(2):405-10.
Keogh, J. B., Luscombe-Marsh, N. D., Noakes, M., Wittert, G. A., & Clifton, P. M. (2007). Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women. The British Journal of Nutrition, 97(2), 405-10.
Keogh JB, et al. Long-term Weight Maintenance and Cardiovascular Risk Factors Are Not Different Following Weight Loss On Carbohydrate-restricted Diets High in Either Monounsaturated Fat or Protein in Obese Hyperinsulinaemic Men and Women. Br J Nutr. 2007;97(2):405-10. PubMed PMID: 17298712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women. AU - Keogh,Jennifer B, AU - Luscombe-Marsh,Natalie D, AU - Noakes,Manny, AU - Wittert,Gary A, AU - Clifton,Peter M, PY - 2007/2/15/pubmed PY - 2007/6/20/medline PY - 2007/2/15/entrez SP - 405 EP - 10 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 97 IS - 2 N2 - The aim of this study was to determine after 52 weeks whether advice to follow a lower carbohydrate diet, either high in monounsaturated fat or low fat, high in protein had differential effects in a free-living community setting. Following weight loss on either a high monounsaturated fat, standard protein (HMF; 50 % fat, 20 % protein (67 g/d), 30 % carbohydrate) or a high protein, moderate fat (HP) (40 % protein (136 g/d), 30 % fat, 30 % carbohydrate) energy-restricted diet (6000 kJ/d) subjects were asked to maintain the same dietary pattern without intensive dietary counselling for the following 36 weeks. Overall weight loss was 6.2 (SD 7.3) kg (P < 0.01 for time with no diet effect, 7.6 (SD 8.1) kg, HMF v. 4.8 (SD 6.6) kg, HP). In a multivariate regression model predictors of weight loss at the end of the study were sex, age and reported percentage energy from protein (R2 0.22, P < 0.05 for the whole model). Fasting plasma insulin decreased (P < 0.01, with no difference between diets), 13.9 (SD 4.6) to 10.2 (SD 5.2) mIU/l, but fasting plasma glucose was not reduced. Neither total cholesterol nor LDL-cholesterol were different but HDL was higher, 1.19 (SD 0.26) v. 1.04 (SD 0.29) (P < 0.001 for time, no diet effect), while TAG was lower, 1.87 (SD 1.23) v. 2.22 (SD 1.15) mmol/l (P < 0.05 for time, no diet effect). C-reactive protein decreased (3.97 (SD 2.84) to 2.43 (SD 2.29) mg/l, P < 0.01). Food records showed that compliance to the prescribed dietary patterns was poor. After 1 year there remained a clinically significant weight loss and improvement in cardiovascular risk factors with no adverse effects of a high monounsaturated fat diet. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17298712/Long_term_weight_maintenance_and_cardiovascular_risk_factors_are_not_different_following_weight_loss_on_carbohydrate_restricted_diets_high_in_either_monounsaturated_fat_or_protein_in_obese_hyperinsulinaemic_men_and_women_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507252687/type/journal_article DB - PRIME DP - Unbound Medicine ER -