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Simultaneous vaccination in Japanese travelers.
Travel Med Infect Dis. 2007 Mar; 5(2):85-9.TM

Abstract

BACKGROUND

Simultaneous vaccination is not common in Japan because there is little information available on its effects. Some people are quite concerned about the possibility of adverse reactions due to simultaneous vaccination. The objective of this study was to evaluate whether the frequency and severity of adverse effects are increased by simultaneous vaccination in comparison to single vaccination.

METHOD

A retrospective observational study was conducted in 399 asymptomatic travelers who visited the travel clinic during the period January-July 2005. One hundred forty-two participants were given a single vaccination, 257 participants were given simultaneous vaccination. Travel-specific vaccinations were for hepatitis A, hepatitis B, tetanus, rabies and Japanese encephalitis, and routine vaccines were for diphtheria+tetanus, measles, mumps and oral polio vaccine. To evaluate adverse effects, travelers were asked to complete a prepared questionnaire after vaccination.

RESULTS

Adverse effects were reported by 26.3% of travelers, with 21.8% reporting local reactions and 4.5% reporting systemic reactions. The simultaneous vaccination group reported significantly more frequent adverse effects than those reported by the single vaccination group. Particularly, tetanus vaccination was shown to significantly raise the risk of adverse effects (P<0.001). However, no serious adverse effects were reported.

CONCLUSIONS

Simultaneous vaccination was feasible for Japanese travelers because most problems were generally minor and related to local reactions at the sites of injections. Provision of a simultaneous vaccination schedule should motivate more Japanese travelers to obtain immunizations and thereby reduce the risk of vaccine-preventable diseases.

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Authors+Show Affiliations

Mizuno Y
Travel Clinic, Disease Control and Prevention Center, International Medical Center of Japan, Tokyo 162-8655, Japan. y-mizuno@it.imcj.go.jp
Kano S
No affiliation info available
Urashima M
No affiliation info available
Genka I
No affiliation info available
Kanagawa S
No affiliation info available
Kudo K
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHepatitis A VaccinesHepatitis B VaccinesHumansImmunization ScheduleInfantInfant, NewbornJapanMaleMeasles VaccineMedical RecordsMiddle AgedMumps VaccinePatient SatisfactionPoliovirus Vaccine, OralRetrospective StudiesSurveys and QuestionnairesTetanus ToxoidTravelVaccination

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17298913

Citation

Mizuno, Yasutaka, et al. "Simultaneous Vaccination in Japanese Travelers." Travel Medicine and Infectious Disease, vol. 5, no. 2, 2007, pp. 85-9.
Mizuno Y, Kano S, Urashima M, et al. Simultaneous vaccination in Japanese travelers. Travel Med Infect Dis. 2007;5(2):85-9.
Mizuno, Y., Kano, S., Urashima, M., Genka, I., Kanagawa, S., & Kudo, K. (2007). Simultaneous vaccination in Japanese travelers. Travel Medicine and Infectious Disease, 5(2), 85-9.
Mizuno Y, et al. Simultaneous Vaccination in Japanese Travelers. Travel Med Infect Dis. 2007;5(2):85-9. PubMed PMID: 17298913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous vaccination in Japanese travelers. AU - Mizuno,Yasutaka, AU - Kano,Shigeyuki, AU - Urashima,Mitsuyoshi, AU - Genka,Ikumi, AU - Kanagawa,Shuzo, AU - Kudo,Koichiro, Y1 - 2006/09/28/ PY - 2005/12/07/received PY - 2006/07/20/revised PY - 2006/09/04/accepted PY - 2007/2/15/pubmed PY - 2007/5/16/medline PY - 2007/2/15/entrez SP - 85 EP - 9 JF - Travel medicine and infectious disease JO - Travel Med Infect Dis VL - 5 IS - 2 N2 - BACKGROUND: Simultaneous vaccination is not common in Japan because there is little information available on its effects. Some people are quite concerned about the possibility of adverse reactions due to simultaneous vaccination. The objective of this study was to evaluate whether the frequency and severity of adverse effects are increased by simultaneous vaccination in comparison to single vaccination. METHOD: A retrospective observational study was conducted in 399 asymptomatic travelers who visited the travel clinic during the period January-July 2005. One hundred forty-two participants were given a single vaccination, 257 participants were given simultaneous vaccination. Travel-specific vaccinations were for hepatitis A, hepatitis B, tetanus, rabies and Japanese encephalitis, and routine vaccines were for diphtheria+tetanus, measles, mumps and oral polio vaccine. To evaluate adverse effects, travelers were asked to complete a prepared questionnaire after vaccination. RESULTS: Adverse effects were reported by 26.3% of travelers, with 21.8% reporting local reactions and 4.5% reporting systemic reactions. The simultaneous vaccination group reported significantly more frequent adverse effects than those reported by the single vaccination group. Particularly, tetanus vaccination was shown to significantly raise the risk of adverse effects (P<0.001). However, no serious adverse effects were reported. CONCLUSIONS: Simultaneous vaccination was feasible for Japanese travelers because most problems were generally minor and related to local reactions at the sites of injections. Provision of a simultaneous vaccination schedule should motivate more Japanese travelers to obtain immunizations and thereby reduce the risk of vaccine-preventable diseases. SN - 1477-8939 UR - https://www.unboundmedicine.com/medline/citation/17298913/Simultaneous_vaccination_in_Japanese_travelers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1477-8939(06)00098-6 DB - PRIME DP - Unbound Medicine ER -