Tags

Type your tag names separated by a space and hit enter

Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects.
Obesity (Silver Spring). 2007 Feb; 15(2):386-91.O

Abstract

OBJECTIVE

Isoprostanes are a marker of oxidant stress and atherosclerotic risk, and plasma concentrations are elevated in obesity. Adiponectin is a regulator of insulin sensitivity, and low circulating levels are associated with oxidant stress and obesity. The aim of this study was to determine the effect of vitamin E supplementation on plasma concentrations of 8-isoprostane and adiponectin in overweight/obese subjects.

RESEARCH METHODS AND PROCEDURES

The study was a 6-month, randomized, double-blind, placebo-controlled trial in 80 overweight subjects (60 women and 20 men, BMI >27 kg/m(2)). Exclusion criteria were serious illness, smoking, or taking antioxidant supplements. Participants were randomized to receive 800 IU/d natural vitamin E (n = 39) or placebo (n = 41) for 3 months with an increase in the dose to 1200 IU/d for a further 3 months. Plasma 8-isoprostane and adiponectin concentrations were measured at baseline and 3 and 6 months.

RESULTS

During 6 months of supplementation with vitamin E, plasma vitamin E concentration increased significantly (p < 0.001) by 76%, and plasma 8-isoprostane concentrations decreased significantly (-11%, p = 0.03), whereas plasma adiponectin concentrations did not change significantly.

DISCUSSION

These findings suggest that supplementation with high-dose vitamin E decreases systemic oxidative stress and 8-isoprostane concentrations in overweight/obese individuals. A decrease in plasma 8-isoprostane has the potential to reduce risk of cardiovascular disease in obesity.

Authors+Show Affiliations

Medicine Section, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. wayne.Sutherland@stonebow.otago.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17299112

Citation

Sutherland, Wayne H F., et al. "Vitamin E Supplementation and Plasma 8-isoprostane and Adiponectin in Overweight Subjects." Obesity (Silver Spring, Md.), vol. 15, no. 2, 2007, pp. 386-91.
Sutherland WH, Manning PJ, Walker RJ, et al. Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects. Obesity (Silver Spring). 2007;15(2):386-91.
Sutherland, W. H., Manning, P. J., Walker, R. J., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2007). Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects. Obesity (Silver Spring, Md.), 15(2), 386-91.
Sutherland WH, et al. Vitamin E Supplementation and Plasma 8-isoprostane and Adiponectin in Overweight Subjects. Obesity (Silver Spring). 2007;15(2):386-91. PubMed PMID: 17299112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects. AU - Sutherland,Wayne H F, AU - Manning,Patrick J, AU - Walker,Robert J, AU - de Jong,Sylvia A, AU - Ryalls,Anne R, AU - Berry,Elizabeth A, PY - 2007/2/15/pubmed PY - 2007/4/27/medline PY - 2007/2/15/entrez SP - 386 EP - 91 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 15 IS - 2 N2 - OBJECTIVE: Isoprostanes are a marker of oxidant stress and atherosclerotic risk, and plasma concentrations are elevated in obesity. Adiponectin is a regulator of insulin sensitivity, and low circulating levels are associated with oxidant stress and obesity. The aim of this study was to determine the effect of vitamin E supplementation on plasma concentrations of 8-isoprostane and adiponectin in overweight/obese subjects. RESEARCH METHODS AND PROCEDURES: The study was a 6-month, randomized, double-blind, placebo-controlled trial in 80 overweight subjects (60 women and 20 men, BMI >27 kg/m(2)). Exclusion criteria were serious illness, smoking, or taking antioxidant supplements. Participants were randomized to receive 800 IU/d natural vitamin E (n = 39) or placebo (n = 41) for 3 months with an increase in the dose to 1200 IU/d for a further 3 months. Plasma 8-isoprostane and adiponectin concentrations were measured at baseline and 3 and 6 months. RESULTS: During 6 months of supplementation with vitamin E, plasma vitamin E concentration increased significantly (p < 0.001) by 76%, and plasma 8-isoprostane concentrations decreased significantly (-11%, p = 0.03), whereas plasma adiponectin concentrations did not change significantly. DISCUSSION: These findings suggest that supplementation with high-dose vitamin E decreases systemic oxidative stress and 8-isoprostane concentrations in overweight/obese individuals. A decrease in plasma 8-isoprostane has the potential to reduce risk of cardiovascular disease in obesity. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/17299112/Vitamin_E_supplementation_and_plasma_8_isoprostane_and_adiponectin_in_overweight_subjects_ L2 - https://doi.org/10.1038/oby.2007.546 DB - PRIME DP - Unbound Medicine ER -