Tags

Type your tag names separated by a space and hit enter

Glucagon-like peptide-1 (7-36) amide response to low versus high glycaemic index preloads in overweight subjects with and without type II diabetes mellitus.
Eur J Clin Nutr 2007; 61(12):1364-72EJ

Abstract

BACKGROUND AND OBJECTIVE

Glucagon-like-peptide-1 (7-36) amide (GLP-1) is an insulin secretagogue and potential treatment for type II diabetes mellitus. An alternative to GLP-1 administration is endogenous dietary stimulation. We described a greater GLP-1 release following ingestion of liquids versus solids. We add to this work studying the effect of fluid preloads with differing glycaemic indices (GI) on the metabolic response to a meal.

SUBJECTS AND DESIGN

GLP-1, insulin and glucose responses were measured in six overweight individuals and six subjects with type II diabetes on three occasions, after preload (milk, low GI; Ovaltine Light, high GI; or water, non-nutritive control) and meal ingestion.

RESULTS

In people with and without diabetes, the high GI preload produced the greatest glucose incremental area under the curve (IAUC)(0-20), followed by the low GI preload, and water (P<0.001). In both groups, insulin IAUC(0-20) was higher following high and low GI preloads compared with water (NS). In people without diabetes, the GLP-1 response was higher when high and low GI preloads were consumed compared with water (P=0.041), with no significant difference between nutritive preloads. GLP-1 response did not differ between preloads in people with diabetes. Despite initial differences, total IAUCs(0-200) for biochemical variables did not differ by preload.

CONCLUSION

We confirm that nutritive liquids stimulate GLP-1 to a greater extent than water in subjects without diabetes; however, this does not influence subsequent meal-induced response. The GI of preloads does not influence the degree of GLP-1 stimulation.

Authors+Show Affiliations

Nutrition and Dietetic Research Group, Hammersmith Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17299480

Citation

Milton, J E., et al. "Glucagon-like Peptide-1 (7-36) Amide Response to Low Versus High Glycaemic Index Preloads in Overweight Subjects With and Without Type II Diabetes Mellitus." European Journal of Clinical Nutrition, vol. 61, no. 12, 2007, pp. 1364-72.
Milton JE, Sananthanan CS, Patterson M, et al. Glucagon-like peptide-1 (7-36) amide response to low versus high glycaemic index preloads in overweight subjects with and without type II diabetes mellitus. Eur J Clin Nutr. 2007;61(12):1364-72.
Milton, J. E., Sananthanan, C. S., Patterson, M., Ghatei, M. A., Bloom, S. R., & Frost, G. S. (2007). Glucagon-like peptide-1 (7-36) amide response to low versus high glycaemic index preloads in overweight subjects with and without type II diabetes mellitus. European Journal of Clinical Nutrition, 61(12), pp. 1364-72.
Milton JE, et al. Glucagon-like Peptide-1 (7-36) Amide Response to Low Versus High Glycaemic Index Preloads in Overweight Subjects With and Without Type II Diabetes Mellitus. Eur J Clin Nutr. 2007;61(12):1364-72. PubMed PMID: 17299480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucagon-like peptide-1 (7-36) amide response to low versus high glycaemic index preloads in overweight subjects with and without type II diabetes mellitus. AU - Milton,J E, AU - Sananthanan,C S, AU - Patterson,M, AU - Ghatei,M A, AU - Bloom,S R, AU - Frost,G S, Y1 - 2007/02/14/ PY - 2007/2/15/pubmed PY - 2008/2/20/medline PY - 2007/2/15/entrez SP - 1364 EP - 72 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 12 N2 - BACKGROUND AND OBJECTIVE: Glucagon-like-peptide-1 (7-36) amide (GLP-1) is an insulin secretagogue and potential treatment for type II diabetes mellitus. An alternative to GLP-1 administration is endogenous dietary stimulation. We described a greater GLP-1 release following ingestion of liquids versus solids. We add to this work studying the effect of fluid preloads with differing glycaemic indices (GI) on the metabolic response to a meal. SUBJECTS AND DESIGN: GLP-1, insulin and glucose responses were measured in six overweight individuals and six subjects with type II diabetes on three occasions, after preload (milk, low GI; Ovaltine Light, high GI; or water, non-nutritive control) and meal ingestion. RESULTS: In people with and without diabetes, the high GI preload produced the greatest glucose incremental area under the curve (IAUC)(0-20), followed by the low GI preload, and water (P<0.001). In both groups, insulin IAUC(0-20) was higher following high and low GI preloads compared with water (NS). In people without diabetes, the GLP-1 response was higher when high and low GI preloads were consumed compared with water (P=0.041), with no significant difference between nutritive preloads. GLP-1 response did not differ between preloads in people with diabetes. Despite initial differences, total IAUCs(0-200) for biochemical variables did not differ by preload. CONCLUSION: We confirm that nutritive liquids stimulate GLP-1 to a greater extent than water in subjects without diabetes; however, this does not influence subsequent meal-induced response. The GI of preloads does not influence the degree of GLP-1 stimulation. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17299480/Glucagon_like_peptide_1__7_36__amide_response_to_low_versus_high_glycaemic_index_preloads_in_overweight_subjects_with_and_without_type_II_diabetes_mellitus_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602654 DB - PRIME DP - Unbound Medicine ER -