Tags

Type your tag names separated by a space and hit enter

Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3: a double-blind, placebo-controlled trial.
Eur J Clin Nutr. 2007 Oct; 61(10):1196-200.EJ

Abstract

OBJECTIVE

Studies have suggested a link between lycopene and insulin-like growth factor-1 (IGF-1). The aim of this study was to test the effect of lycopene supplementation on IGF-1 and binding protein-3 (IGFBP-3) status in healthy male volunteers. DESIGN, SETTING, SUBJECTS AND INTERVENTION: This was a 4 week randomized, double-blind, placebo-controlled study of lycopene supplementation (15 mg/day) in healthy male volunteers (n=20). Fasting blood samples were collected at baseline and after 4 weeks. Samples were analysed for lycopene by high-performance liquid chromatography (HPLC) and IGF-1 and IGFBP-3 by enzyme-linked immunosorbent assay (ELISA). Changes in end points from baseline were compared in those who received placebo versus those who received the lycopene supplement.

RESULTS

Median change in lycopene from baseline (post-supplement - baseline) was higher in subjects in the intervention than those on placebo (lycopene group 0.29 (0.09, 0.46); placebo group 0.03 (-0.11, 0.08) micromol/l; median (25th, 75th percentiles), P<0.01). There was no difference in median change in IGF-1 concentrations (lycopene group -0.6 (-2.6, 1.9); placebo group -1.15 (-2.88, 0.95) nmol/l, P=0.52), or median change in IGFBP-3 concentrations (lycopene group 245 (-109, 484); placebo group 101 (-34, 234) nmol/l, P=0.55) between intervention and control groups. Change in lycopene concentration was associated with the change in IGFBP-3 in the intervention group (r=0.78; P=0.008; n=10).

CONCLUSIONS

Lycopene supplementation in healthy male subjects has no effect on IGF-1 or IGFBP-3 concentrations in a healthy male population. However, the association between change in lycopene concentration and change in IGFBP-3 in the intervention group suggests a potential effect of lycopene supplementation on IGFBP-3.

Authors+Show Affiliations

Nutrition and Metabolism Group, Centre for Clinical and Population Science, Queen's University Belfast, Northern Ireland, Belfast, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17299493

Citation

Graydon, R, et al. "Effect of Lycopene Supplementation On Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3: a Double-blind, Placebo-controlled Trial." European Journal of Clinical Nutrition, vol. 61, no. 10, 2007, pp. 1196-200.
Graydon R, Gilchrist SE, Young IS, et al. Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3: a double-blind, placebo-controlled trial. Eur J Clin Nutr. 2007;61(10):1196-200.
Graydon, R., Gilchrist, S. E., Young, I. S., Obermüller-Jevic, U., Hasselwander, O., & Woodside, J. V. (2007). Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3: a double-blind, placebo-controlled trial. European Journal of Clinical Nutrition, 61(10), 1196-200.
Graydon R, et al. Effect of Lycopene Supplementation On Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3: a Double-blind, Placebo-controlled Trial. Eur J Clin Nutr. 2007;61(10):1196-200. PubMed PMID: 17299493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3: a double-blind, placebo-controlled trial. AU - Graydon,R, AU - Gilchrist,S E C M, AU - Young,I S, AU - Obermüller-Jevic,U, AU - Hasselwander,O, AU - Woodside,J V, Y1 - 2007/02/07/ PY - 2007/2/15/pubmed PY - 2008/1/23/medline PY - 2007/2/15/entrez SP - 1196 EP - 200 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 10 N2 - OBJECTIVE: Studies have suggested a link between lycopene and insulin-like growth factor-1 (IGF-1). The aim of this study was to test the effect of lycopene supplementation on IGF-1 and binding protein-3 (IGFBP-3) status in healthy male volunteers. DESIGN, SETTING, SUBJECTS AND INTERVENTION: This was a 4 week randomized, double-blind, placebo-controlled study of lycopene supplementation (15 mg/day) in healthy male volunteers (n=20). Fasting blood samples were collected at baseline and after 4 weeks. Samples were analysed for lycopene by high-performance liquid chromatography (HPLC) and IGF-1 and IGFBP-3 by enzyme-linked immunosorbent assay (ELISA). Changes in end points from baseline were compared in those who received placebo versus those who received the lycopene supplement. RESULTS: Median change in lycopene from baseline (post-supplement - baseline) was higher in subjects in the intervention than those on placebo (lycopene group 0.29 (0.09, 0.46); placebo group 0.03 (-0.11, 0.08) micromol/l; median (25th, 75th percentiles), P<0.01). There was no difference in median change in IGF-1 concentrations (lycopene group -0.6 (-2.6, 1.9); placebo group -1.15 (-2.88, 0.95) nmol/l, P=0.52), or median change in IGFBP-3 concentrations (lycopene group 245 (-109, 484); placebo group 101 (-34, 234) nmol/l, P=0.55) between intervention and control groups. Change in lycopene concentration was associated with the change in IGFBP-3 in the intervention group (r=0.78; P=0.008; n=10). CONCLUSIONS: Lycopene supplementation in healthy male subjects has no effect on IGF-1 or IGFBP-3 concentrations in a healthy male population. However, the association between change in lycopene concentration and change in IGFBP-3 in the intervention group suggests a potential effect of lycopene supplementation on IGFBP-3. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17299493/Effect_of_lycopene_supplementation_on_insulin_like_growth_factor_1_and_insulin_like_growth_factor_binding_protein_3:_a_double_blind_placebo_controlled_trial_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602632 DB - PRIME DP - Unbound Medicine ER -