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Dietary fat intake and the risk of osteoporotic fractures in the elderly.
Eur J Clin Nutr. 2007 Sep; 61(9):1114-20.EJ

Abstract

OBJECTIVE

To explore the association between fat intake, serum lipids and the risk of osteoporotic fractures in the elderly.

DESIGN

A hospital-based case-control study.

SETTING

The study was conducted at a tertiary centre and referral hospital for the province of Jaén (Spain).

SUBJECTS

Cases (n=167) were patients aged 65 years or more with a low-energy fracture selected from the population attended at the hospital. Controls (patients without antecedents of any fracture) were 1:1 matched to cases by sex and age (n=167).

METHODS

Diet was assessed by a semiquantitative food frequency questionnaire. Serum total cholesterol and high-density lipoprotein (HDL) cholesterol were also measured.

RESULTS

Participants in the two upper quartiles of polyunsaturated fat (PUFA) intake showed an increased risk of fracture, with statistically significant differences with respect to the first quartile in the adjusted model (odds ratio (OR)=3.59; 95% confidence interval (CI)=1.06-12.1 and OR=5.88; 95% CI=1.38-25.02); P=0.01 for the trend test). A higher ratio of monounsaturated fat (MUFA) to PUFA was associated with a reduced risk of fracture (OR=0.20; 95% CI=0.07-0.60 for the fourth quartile; P=0.002 for the trend test). The intake of omega-6 fatty acids was associated with an elevated risk of fracture (OR=3.41; 95% CI=1.05-11.15 for the fourth quartile; P=0.01 for the trend test). HDL-cholesterol levels were inversely associated with the risk of fracture (test for trend P=0.03 across quartiles).

CONCLUSIONS

PUFA intake was associated with an increased risk of osteoporotic fractures in the elderly, whereas a high ratio of MUFA:PUFA was associated with decreased risk.

Authors+Show Affiliations

Service of Endocrinology and Nutrition, Hospital of Jaén & Division of Medicine, University of Jaén, Navarra, Spain. mamartinez@unav.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17299494

Citation

Martínez-Ramírez, M J., et al. "Dietary Fat Intake and the Risk of Osteoporotic Fractures in the Elderly." European Journal of Clinical Nutrition, vol. 61, no. 9, 2007, pp. 1114-20.
Martínez-Ramírez MJ, Palma S, Martínez-González MA, et al. Dietary fat intake and the risk of osteoporotic fractures in the elderly. Eur J Clin Nutr. 2007;61(9):1114-20.
Martínez-Ramírez, M. J., Palma, S., Martínez-González, M. A., Delgado-Martínez, A. D., de la Fuente, C., & Delgado-Rodríguez, M. (2007). Dietary fat intake and the risk of osteoporotic fractures in the elderly. European Journal of Clinical Nutrition, 61(9), 1114-20.
Martínez-Ramírez MJ, et al. Dietary Fat Intake and the Risk of Osteoporotic Fractures in the Elderly. Eur J Clin Nutr. 2007;61(9):1114-20. PubMed PMID: 17299494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat intake and the risk of osteoporotic fractures in the elderly. AU - Martínez-Ramírez,M J, AU - Palma,S, AU - Martínez-González,M A, AU - Delgado-Martínez,A D, AU - de la Fuente,C, AU - Delgado-Rodríguez,M, Y1 - 2007/02/07/ PY - 2007/2/15/pubmed PY - 2007/12/6/medline PY - 2007/2/15/entrez SP - 1114 EP - 20 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 9 N2 - OBJECTIVE: To explore the association between fat intake, serum lipids and the risk of osteoporotic fractures in the elderly. DESIGN: A hospital-based case-control study. SETTING: The study was conducted at a tertiary centre and referral hospital for the province of Jaén (Spain). SUBJECTS: Cases (n=167) were patients aged 65 years or more with a low-energy fracture selected from the population attended at the hospital. Controls (patients without antecedents of any fracture) were 1:1 matched to cases by sex and age (n=167). METHODS: Diet was assessed by a semiquantitative food frequency questionnaire. Serum total cholesterol and high-density lipoprotein (HDL) cholesterol were also measured. RESULTS: Participants in the two upper quartiles of polyunsaturated fat (PUFA) intake showed an increased risk of fracture, with statistically significant differences with respect to the first quartile in the adjusted model (odds ratio (OR)=3.59; 95% confidence interval (CI)=1.06-12.1 and OR=5.88; 95% CI=1.38-25.02); P=0.01 for the trend test). A higher ratio of monounsaturated fat (MUFA) to PUFA was associated with a reduced risk of fracture (OR=0.20; 95% CI=0.07-0.60 for the fourth quartile; P=0.002 for the trend test). The intake of omega-6 fatty acids was associated with an elevated risk of fracture (OR=3.41; 95% CI=1.05-11.15 for the fourth quartile; P=0.01 for the trend test). HDL-cholesterol levels were inversely associated with the risk of fracture (test for trend P=0.03 across quartiles). CONCLUSIONS: PUFA intake was associated with an increased risk of osteoporotic fractures in the elderly, whereas a high ratio of MUFA:PUFA was associated with decreased risk. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17299494/Dietary_fat_intake_and_the_risk_of_osteoporotic_fractures_in_the_elderly_ L2 - https://doi.org/10.1038/sj.ejcn.1602624 DB - PRIME DP - Unbound Medicine ER -