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Repeated low-dose ultraviolet (UV) B exposures of humans induce limited photoprotection against the immune effects of erythemal UVB radiation.
Br J Dermatol. 2007 Mar; 156(3):539-47.BJ

Abstract

BACKGROUND

Exposure of human subjects to ultraviolet (UV) B radiation causes immunosuppression. Most experiments to date have not tested the effects of low daily doses of UVB radiation.

OBJECTIVES

To ascertain whether photoprotection against several UV-induced immune effects might develop following repeated exposure.

METHODS

Groups of approximately 30 healthy individuals were given whole-body UVB irradiation on each of 10 consecutive days with 0.7 minimal erythema dose, or whole-body irradiation as before followed by a single erythemal UVB dose on a small body area, or irradiated only with a single erythemal UVB dose on a small body area, or were not irradiated. They were sensitized with diphenylcyclopropenone (DPCP) 24 h after the final dose, and skin biopsies collected to assess cytokine mRNA expression and the number of cells with thymine dimers and expression cyclooxygenase (COX)-1 and COX-2.

RESULTS

The contact hypersensitivity (CHS) response to DPCP was significantly lower in the three irradiated groups compared with the unirradiated controls, while cutaneous interleukin (IL)-1beta, IL-6, IL-10 and tumour necrosis factor-alpha mRNAs, COX-1 and COX-2 and thymine dimers were all significantly higher. When the single erythemal UVB dose was given following the repeated low exposures, a slight downregulation in cytokine expression and thymine dimer formation was indicated.

CONCLUSIONS

The repeated low doses of UVB protected to a limited extent against the effects of an erythemal UVB dose on cytokine expression and thymine dimer formation, but not on CHS or COX enzymes.

Authors+Show Affiliations

Department of Dermatology, Medical University of Lodz, Krzemieniecka 5, 94-017 Lodz, Poland. joanna.narbutt@onet.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17300245

Citation

Narbutt, J, et al. "Repeated Low-dose Ultraviolet (UV) B Exposures of Humans Induce Limited Photoprotection Against the Immune Effects of Erythemal UVB Radiation." The British Journal of Dermatology, vol. 156, no. 3, 2007, pp. 539-47.
Narbutt J, Lesiak A, Sysa-Jedrzejowska A, et al. Repeated low-dose ultraviolet (UV) B exposures of humans induce limited photoprotection against the immune effects of erythemal UVB radiation. Br J Dermatol. 2007;156(3):539-47.
Narbutt, J., Lesiak, A., Sysa-Jedrzejowska, A., Wozniacka, A., Cierniewska-Cieslak, A., Boncela, J., Jochymski, C., Kozlowski, W., Zalewska, A., Skibinska, M., & Norval, M. (2007). Repeated low-dose ultraviolet (UV) B exposures of humans induce limited photoprotection against the immune effects of erythemal UVB radiation. The British Journal of Dermatology, 156(3), 539-47.
Narbutt J, et al. Repeated Low-dose Ultraviolet (UV) B Exposures of Humans Induce Limited Photoprotection Against the Immune Effects of Erythemal UVB Radiation. Br J Dermatol. 2007;156(3):539-47. PubMed PMID: 17300245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated low-dose ultraviolet (UV) B exposures of humans induce limited photoprotection against the immune effects of erythemal UVB radiation. AU - Narbutt,J, AU - Lesiak,A, AU - Sysa-Jedrzejowska,A, AU - Wozniacka,A, AU - Cierniewska-Cieslak,A, AU - Boncela,J, AU - Jochymski,C, AU - Kozlowski,W, AU - Zalewska,A, AU - Skibinska,M, AU - Norval,M, PY - 2007/2/16/pubmed PY - 2007/6/27/medline PY - 2007/2/16/entrez SP - 539 EP - 47 JF - The British journal of dermatology JO - Br J Dermatol VL - 156 IS - 3 N2 - BACKGROUND: Exposure of human subjects to ultraviolet (UV) B radiation causes immunosuppression. Most experiments to date have not tested the effects of low daily doses of UVB radiation. OBJECTIVES: To ascertain whether photoprotection against several UV-induced immune effects might develop following repeated exposure. METHODS: Groups of approximately 30 healthy individuals were given whole-body UVB irradiation on each of 10 consecutive days with 0.7 minimal erythema dose, or whole-body irradiation as before followed by a single erythemal UVB dose on a small body area, or irradiated only with a single erythemal UVB dose on a small body area, or were not irradiated. They were sensitized with diphenylcyclopropenone (DPCP) 24 h after the final dose, and skin biopsies collected to assess cytokine mRNA expression and the number of cells with thymine dimers and expression cyclooxygenase (COX)-1 and COX-2. RESULTS: The contact hypersensitivity (CHS) response to DPCP was significantly lower in the three irradiated groups compared with the unirradiated controls, while cutaneous interleukin (IL)-1beta, IL-6, IL-10 and tumour necrosis factor-alpha mRNAs, COX-1 and COX-2 and thymine dimers were all significantly higher. When the single erythemal UVB dose was given following the repeated low exposures, a slight downregulation in cytokine expression and thymine dimer formation was indicated. CONCLUSIONS: The repeated low doses of UVB protected to a limited extent against the effects of an erythemal UVB dose on cytokine expression and thymine dimer formation, but not on CHS or COX enzymes. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/17300245/Repeated_low_dose_ultraviolet__UV__B_exposures_of_humans_induce_limited_photoprotection_against_the_immune_effects_of_erythemal_UVB_radiation_ L2 - https://doi.org/10.1111/j.1365-2133.2006.07670.x DB - PRIME DP - Unbound Medicine ER -