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Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date.
Neurogastroenterol Motil. 2007 Mar; 19(3):166-72.NM

Abstract

Probiotics, defined as live organisms that, when ingested in adequate amounts, exert a health benefit on the host, have been used for almost a century in the management of a variety of medical disorders, usually on the basis of little evidence. Advances in our understanding of the gut flora and of its relationship to the host, together with progress in microbiology, molecular biology and clinical research have identified important biological properties for probiotics and demonstrated efficacy in a number of gastrointestinal disorders. The clear delineation of a post-infective variety of irritable bowel syndrome (IBS), as well as the description, in a number of studies, of evidence of low-grade inflammation and immune activation in IBS, suggest a role for a dysfunctional relationship between the indigenous flora and the host in IBS and, accordingly, provide a clear rationale for the use of probiotics in this disorder. Other modes of action, including bacterial displacement and alterations in luminal contents, are also plausible. While clinical evidence of efficacy is now beginning to emerge, a review of available trials emphasises the importance of clear definition of strain selection, dose and viability. This is evidently an area of great potential in IBS and deserves further study at all levels.

Authors+Show Affiliations

Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. e.quigley@ucc.ieNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17300285

Citation

Quigley, E M M., and B Flourie. "Probiotics and Irritable Bowel Syndrome: a Rationale for Their Use and an Assessment of the Evidence to Date." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 19, no. 3, 2007, pp. 166-72.
Quigley EM, Flourie B. Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date. Neurogastroenterol Motil. 2007;19(3):166-72.
Quigley, E. M., & Flourie, B. (2007). Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 19(3), 166-72.
Quigley EM, Flourie B. Probiotics and Irritable Bowel Syndrome: a Rationale for Their Use and an Assessment of the Evidence to Date. Neurogastroenterol Motil. 2007;19(3):166-72. PubMed PMID: 17300285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date. AU - Quigley,E M M, AU - Flourie,B, PY - 2007/2/16/pubmed PY - 2007/5/5/medline PY - 2007/2/16/entrez SP - 166 EP - 72 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol Motil VL - 19 IS - 3 N2 - Probiotics, defined as live organisms that, when ingested in adequate amounts, exert a health benefit on the host, have been used for almost a century in the management of a variety of medical disorders, usually on the basis of little evidence. Advances in our understanding of the gut flora and of its relationship to the host, together with progress in microbiology, molecular biology and clinical research have identified important biological properties for probiotics and demonstrated efficacy in a number of gastrointestinal disorders. The clear delineation of a post-infective variety of irritable bowel syndrome (IBS), as well as the description, in a number of studies, of evidence of low-grade inflammation and immune activation in IBS, suggest a role for a dysfunctional relationship between the indigenous flora and the host in IBS and, accordingly, provide a clear rationale for the use of probiotics in this disorder. Other modes of action, including bacterial displacement and alterations in luminal contents, are also plausible. While clinical evidence of efficacy is now beginning to emerge, a review of available trials emphasises the importance of clear definition of strain selection, dose and viability. This is evidently an area of great potential in IBS and deserves further study at all levels. SN - 1350-1925 UR - https://www.unboundmedicine.com/medline/citation/17300285/Probiotics_and_irritable_bowel_syndrome:_a_rationale_for_their_use_and_an_assessment_of_the_evidence_to_date_ L2 - https://doi.org/10.1111/j.1365-2982.2006.00879.x DB - PRIME DP - Unbound Medicine ER -