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Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats.
Eur J Pharmacol 2007; 560(2-3):110-6EJ

Abstract

Oxidative stress is a common mechanism contributing to initiation and progression of hepatic damage in a variety of liver disorders. Hence, there is a great demand for the development of agents with potent antioxidant effect. The aim of the present investigation is to evaluate the efficacy of silymarin as a hepatoprotective and an antioxidant against diethylnitrosamine induced hepatocellular damage. Single intraperitoneal administration of diethylnitrosamine (200 mg/kg) to rats resulted in significantly elevated levels of serum aspartate transaminase (AST) and alanine transaminase (ALT), which is indicative of hepatocellular damage. Diethylnitrosamine induced oxidative stress was confirmed by elevated levels of lipid peroxidation and decreased levels of superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione reductase (GR) and glutathione-S-transferase (GST) in the liver tissue. The status of non-enzymic antioxidants like, vitamin-C, vitamin-E and reduced glutathione (GSH) were also found to be decreased in diethylnitrosamine administered rats. Further, the status of membrane bound ATPases was also altered indicating hepatocellular membrane damage. Posttreatment with the silymarin (50 mg/kg) orally for 30 days significantly reversed the diethylnitrosamine induced alterations in the liver tissue and offered almost complete protection. The results from the present study indicate that silymarin exhibits good hepatoprotective and antioxidant potential against diethylnitrosamine induced hepatocellular damage in rats.

Authors+Show Affiliations

Department of Pharmacology and Environmental Toxicology, Dr. A.L.M.P.G. Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India. kannampallipradeep@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17300777

Citation

Pradeep, Kannampalli, et al. "Silymarin Modulates the Oxidant-antioxidant Imbalance During Diethylnitrosamine Induced Oxidative Stress in Rats." European Journal of Pharmacology, vol. 560, no. 2-3, 2007, pp. 110-6.
Pradeep K, Mohan CV, Gobianand K, et al. Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol. 2007;560(2-3):110-6.
Pradeep, K., Mohan, C. V., Gobianand, K., & Karthikeyan, S. (2007). Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. European Journal of Pharmacology, 560(2-3), pp. 110-6.
Pradeep K, et al. Silymarin Modulates the Oxidant-antioxidant Imbalance During Diethylnitrosamine Induced Oxidative Stress in Rats. Eur J Pharmacol. 2007 Apr 10;560(2-3):110-6. PubMed PMID: 17300777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. AU - Pradeep,Kannampalli, AU - Mohan,Chandrasekaran Victor Raj, AU - Gobianand,Kuppanan, AU - Karthikeyan,Sivanesan, Y1 - 2007/01/19/ PY - 2006/10/15/received PY - 2006/12/16/revised PY - 2006/12/21/accepted PY - 2007/2/16/pubmed PY - 2007/6/7/medline PY - 2007/2/16/entrez SP - 110 EP - 6 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 560 IS - 2-3 N2 - Oxidative stress is a common mechanism contributing to initiation and progression of hepatic damage in a variety of liver disorders. Hence, there is a great demand for the development of agents with potent antioxidant effect. The aim of the present investigation is to evaluate the efficacy of silymarin as a hepatoprotective and an antioxidant against diethylnitrosamine induced hepatocellular damage. Single intraperitoneal administration of diethylnitrosamine (200 mg/kg) to rats resulted in significantly elevated levels of serum aspartate transaminase (AST) and alanine transaminase (ALT), which is indicative of hepatocellular damage. Diethylnitrosamine induced oxidative stress was confirmed by elevated levels of lipid peroxidation and decreased levels of superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione reductase (GR) and glutathione-S-transferase (GST) in the liver tissue. The status of non-enzymic antioxidants like, vitamin-C, vitamin-E and reduced glutathione (GSH) were also found to be decreased in diethylnitrosamine administered rats. Further, the status of membrane bound ATPases was also altered indicating hepatocellular membrane damage. Posttreatment with the silymarin (50 mg/kg) orally for 30 days significantly reversed the diethylnitrosamine induced alterations in the liver tissue and offered almost complete protection. The results from the present study indicate that silymarin exhibits good hepatoprotective and antioxidant potential against diethylnitrosamine induced hepatocellular damage in rats. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17300777/Silymarin_modulates_the_oxidant_antioxidant_imbalance_during_diethylnitrosamine_induced_oxidative_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)00043-X DB - PRIME DP - Unbound Medicine ER -