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Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancer.
Cancer Epidemiol Biomarkers Prev. 2007 Feb; 16(2):236-43.CE

Abstract

Numerous studies have observed reduced breast cancer risk with increasing levels of physical activity, yet these findings have been inconsistent about optimal times of activity and effect modification by other factors. We investigated the association between recreational and occupational physical activity and breast cancer risk in a population-based case-control study in Massachusetts, New Hampshire, and Wisconsin. During structured telephone interviews, 7,630 controls, 1,689 in situ, and 6,391 invasive breast cancer cases, ages 20 to 69 years, reported lifetime history of recreational physical activity and occupation. Neither lifetime recreational nor strenuous occupational physical activity appeared to be associated with risk of breast carcinoma in situ. In contrast, recreational physical activity was associated with a reduced risk of invasive breast cancer. After adjustment for potentially confounding factors, women averaging >6 h per week of strenuous recreational activity over their lifetime had a 23% reduction in the odds ratio of invasive breast cancer when compared with women reporting no recreational activity (95% confidence interval, 0.65-0.92; P(trend) = 0.05). However, this reduction in risk was limited to women without a first-degree family history of breast cancer (P(interaction) = 0.02). Inverse associations were observed for physical activity early in life, in the postmenopausal years, and in the recent past, but these findings were confined to women without a family history of breast cancer. Lifetime strenuous occupational activity was not associated with invasive breast cancer risk. These results provide further evidence that, for most women, physical activity may reduce the risk of invasive breast cancer.

Authors+Show Affiliations

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Department of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53726, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17301255

Citation

Sprague, Brian L., et al. "Lifetime Recreational and Occupational Physical Activity and Risk of in Situ and Invasive Breast Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 16, no. 2, 2007, pp. 236-43.
Sprague BL, Trentham-Dietz A, Newcomb PA, et al. Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancer. Cancer Epidemiol Biomarkers Prev. 2007;16(2):236-43.
Sprague, B. L., Trentham-Dietz, A., Newcomb, P. A., Titus-Ernstoff, L., Hampton, J. M., & Egan, K. M. (2007). Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 16(2), 236-43.
Sprague BL, et al. Lifetime Recreational and Occupational Physical Activity and Risk of in Situ and Invasive Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2007;16(2):236-43. PubMed PMID: 17301255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancer. AU - Sprague,Brian L, AU - Trentham-Dietz,Amy, AU - Newcomb,Polly A, AU - Titus-Ernstoff,Linda, AU - Hampton,John M, AU - Egan,Kathleen M, PY - 2007/2/16/pubmed PY - 2007/4/4/medline PY - 2007/2/16/entrez SP - 236 EP - 43 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 16 IS - 2 N2 - Numerous studies have observed reduced breast cancer risk with increasing levels of physical activity, yet these findings have been inconsistent about optimal times of activity and effect modification by other factors. We investigated the association between recreational and occupational physical activity and breast cancer risk in a population-based case-control study in Massachusetts, New Hampshire, and Wisconsin. During structured telephone interviews, 7,630 controls, 1,689 in situ, and 6,391 invasive breast cancer cases, ages 20 to 69 years, reported lifetime history of recreational physical activity and occupation. Neither lifetime recreational nor strenuous occupational physical activity appeared to be associated with risk of breast carcinoma in situ. In contrast, recreational physical activity was associated with a reduced risk of invasive breast cancer. After adjustment for potentially confounding factors, women averaging >6 h per week of strenuous recreational activity over their lifetime had a 23% reduction in the odds ratio of invasive breast cancer when compared with women reporting no recreational activity (95% confidence interval, 0.65-0.92; P(trend) = 0.05). However, this reduction in risk was limited to women without a first-degree family history of breast cancer (P(interaction) = 0.02). Inverse associations were observed for physical activity early in life, in the postmenopausal years, and in the recent past, but these findings were confined to women without a family history of breast cancer. Lifetime strenuous occupational activity was not associated with invasive breast cancer risk. These results provide further evidence that, for most women, physical activity may reduce the risk of invasive breast cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17301255/Lifetime_recreational_and_occupational_physical_activity_and_risk_of_in_situ_and_invasive_breast_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17301255 DB - PRIME DP - Unbound Medicine ER -