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Cutaneous clear cell squamous cell carcinoma in situ : clinical, histological and immunohistochemical characterization.
J Cutan Pathol. 2007 Mar; 34(3):226-33.JC

Abstract

BACKGROUND

Clear cell squamous cell carcinoma in situ (SCCIS) has not been defined in the literature with respect to its clinical, histological, and immunohistochemical features.

METHODS

Nearly 1500 consecutive cases of SCCIS were assessed for percent clear cell change. The clinical features of all SCCIS with >or=10% clear cell change, including age, sex and site distribution, were compared with classical SCCIS using chi-square analysis. PAS special staining and immunohistochemical analysis with 11 cell markers were performed to characterize the clear cell of origin.

RESULTS

Eighty SCCIS cases with a spectrum of clear cell change of >or=10% were identified. Six cases with >or=80% clear cells were defined as clear cell SCCIS. The clinical features of the cases did not vary significantly from classical SCCIS. Antibodies labeling outer root sheath (ORS) cells also labeled clear cells in the cases and included K8.12 (labeling CK13 and CK16), cellular retinoic acid binding protein II, CAM 5.2 and CK15. Antibodies that did not label ORS cells, but did label eccrine glands (CK7 and CK18) or sebocytes (EMA), also did not label the cases.

CONCLUSION

Clear cell change in SCCIS is part of a spectrum which displays ORS differentiation.

Authors+Show Affiliations

Boston University School of Medicine and Boston University Medical Center, Boston, MA 02118, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17302606

Citation

Al-Arashi, Munir Yahya Hussein, and H Randolph Byers. "Cutaneous Clear Cell Squamous Cell Carcinoma in Situ : Clinical, Histological and Immunohistochemical Characterization." Journal of Cutaneous Pathology, vol. 34, no. 3, 2007, pp. 226-33.
Al-Arashi MY, Byers HR. Cutaneous clear cell squamous cell carcinoma in situ : clinical, histological and immunohistochemical characterization. J Cutan Pathol. 2007;34(3):226-33.
Al-Arashi, M. Y., & Byers, H. R. (2007). Cutaneous clear cell squamous cell carcinoma in situ : clinical, histological and immunohistochemical characterization. Journal of Cutaneous Pathology, 34(3), 226-33.
Al-Arashi MY, Byers HR. Cutaneous Clear Cell Squamous Cell Carcinoma in Situ : Clinical, Histological and Immunohistochemical Characterization. J Cutan Pathol. 2007;34(3):226-33. PubMed PMID: 17302606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous clear cell squamous cell carcinoma in situ : clinical, histological and immunohistochemical characterization. AU - Al-Arashi,Munir Yahya Hussein, AU - Byers,H Randolph, PY - 2007/2/17/pubmed PY - 2007/3/28/medline PY - 2007/2/17/entrez SP - 226 EP - 33 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 34 IS - 3 N2 - BACKGROUND: Clear cell squamous cell carcinoma in situ (SCCIS) has not been defined in the literature with respect to its clinical, histological, and immunohistochemical features. METHODS: Nearly 1500 consecutive cases of SCCIS were assessed for percent clear cell change. The clinical features of all SCCIS with >or=10% clear cell change, including age, sex and site distribution, were compared with classical SCCIS using chi-square analysis. PAS special staining and immunohistochemical analysis with 11 cell markers were performed to characterize the clear cell of origin. RESULTS: Eighty SCCIS cases with a spectrum of clear cell change of >or=10% were identified. Six cases with >or=80% clear cells were defined as clear cell SCCIS. The clinical features of the cases did not vary significantly from classical SCCIS. Antibodies labeling outer root sheath (ORS) cells also labeled clear cells in the cases and included K8.12 (labeling CK13 and CK16), cellular retinoic acid binding protein II, CAM 5.2 and CK15. Antibodies that did not label ORS cells, but did label eccrine glands (CK7 and CK18) or sebocytes (EMA), also did not label the cases. CONCLUSION: Clear cell change in SCCIS is part of a spectrum which displays ORS differentiation. SN - 0303-6987 UR - https://www.unboundmedicine.com/medline/citation/17302606/Cutaneous_clear_cell_squamous_cell_carcinoma_in_situ_:_clinical_histological_and_immunohistochemical_characterization_ L2 - https://doi.org/10.1111/j.1600-0560.2006.00593.x DB - PRIME DP - Unbound Medicine ER -