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Serum resistin is associated with the severity of microangiopathies in type 2 diabetes.
Biochem Biophys Res Commun. 2007 Apr 06; 355(2):342-6.BB

Abstract

Resistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents. To determine the relation between serum resistin and diabetic microangiopathies in humans, we analyzed 238 Japanese T2DM subjects. Mean serum resistin was higher in subjects with either advanced retinopathy (preproliferative or proliferative) (P=0.0130), advanced nephropathy (stage III or IV) (P=0.0151), or neuropathy (P=0.0013). Simple regression analysis showed that serum resistin was positively correlated with retinopathy stage (P=0.0212), nephropathy stage (P=0.0052), and neuropathy (P=0.0013). Multiple regression analysis adjusted for age, gender, and BMI, revealed that serum resistin was correlated with retinopathy stage (P=0.0144), nephropathy stage (P=0.0111), and neuropathy (P=0.0053). Serum resistin was positively correlated with the number of advanced microangiopathies, independent of age, gender, BMI, and either the duration of T2DM (P=0.0318) or serum creatinine (P=0.0092). Therefore, serum resistin was positively correlated with the severity of microangiopathies in T2DM.

Authors+Show Affiliations

Department of Molecular and Genetic Medicine, Ehime, University Graduate School of Medicine, Toon, Ehime 791-0295, Japan. harosawa@m.ehime-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17303077

Citation

Osawa, Haruhiko, et al. "Serum Resistin Is Associated With the Severity of Microangiopathies in Type 2 Diabetes." Biochemical and Biophysical Research Communications, vol. 355, no. 2, 2007, pp. 342-6.
Osawa H, Ochi M, Kato K, et al. Serum resistin is associated with the severity of microangiopathies in type 2 diabetes. Biochem Biophys Res Commun. 2007;355(2):342-6.
Osawa, H., Ochi, M., Kato, K., Yamauchi, J., Nishida, W., Takata, Y., Kawamura, R., Onuma, H., Takasuka, T., Shimizu, I., Fujii, Y., Ohashi, J., & Makino, H. (2007). Serum resistin is associated with the severity of microangiopathies in type 2 diabetes. Biochemical and Biophysical Research Communications, 355(2), 342-6.
Osawa H, et al. Serum Resistin Is Associated With the Severity of Microangiopathies in Type 2 Diabetes. Biochem Biophys Res Commun. 2007 Apr 6;355(2):342-6. PubMed PMID: 17303077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum resistin is associated with the severity of microangiopathies in type 2 diabetes. AU - Osawa,Haruhiko, AU - Ochi,Masaaki, AU - Kato,Kenichi, AU - Yamauchi,Junko, AU - Nishida,Wataru, AU - Takata,Yasunori, AU - Kawamura,Ryoichi, AU - Onuma,Hiroshi, AU - Takasuka,Tomomi, AU - Shimizu,Ikki, AU - Fujii,Yasuhisa, AU - Ohashi,Jun, AU - Makino,Hideichi, Y1 - 2007/02/05/ PY - 2007/01/22/received PY - 2007/01/28/accepted PY - 2007/2/17/pubmed PY - 2007/4/14/medline PY - 2007/2/17/entrez SP - 342 EP - 6 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 355 IS - 2 N2 - Resistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents. To determine the relation between serum resistin and diabetic microangiopathies in humans, we analyzed 238 Japanese T2DM subjects. Mean serum resistin was higher in subjects with either advanced retinopathy (preproliferative or proliferative) (P=0.0130), advanced nephropathy (stage III or IV) (P=0.0151), or neuropathy (P=0.0013). Simple regression analysis showed that serum resistin was positively correlated with retinopathy stage (P=0.0212), nephropathy stage (P=0.0052), and neuropathy (P=0.0013). Multiple regression analysis adjusted for age, gender, and BMI, revealed that serum resistin was correlated with retinopathy stage (P=0.0144), nephropathy stage (P=0.0111), and neuropathy (P=0.0053). Serum resistin was positively correlated with the number of advanced microangiopathies, independent of age, gender, BMI, and either the duration of T2DM (P=0.0318) or serum creatinine (P=0.0092). Therefore, serum resistin was positively correlated with the severity of microangiopathies in T2DM. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/17303077/Serum_resistin_is_associated_with_the_severity_of_microangiopathies_in_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(07)00209-4 DB - PRIME DP - Unbound Medicine ER -