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The metabolic syndrome in polycystic ovary syndrome.
Clin Obstet Gynecol. 2007 Mar; 50(1):205-25.CO

Abstract

Approximately one-third to one-half of all women and adolescent girls with polycystic ovary syndrome (PCOS) has the metabolic syndrome, associated with increased risk for cardiovascular disease and type 2 diabetes. Evidence suggests that insulin resistance is the likely link between PCOS and the metabolic syndrome. Early screening for impaired glucose tolerance, even in adolescents, is recommended. Lifestyle modification with increased physical activity and weight reduction remains first-line therapy. Insulin-sensitizing drugs may also ameliorate features of the metabolic syndrome in PCOS but long-term prospective studies are needed to determine the role of these drugs in the prevention of the metabolic syndrome.

Authors+Show Affiliations

Essah PA
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA. paessah@hsc.vcu.edu
Wickham EP
No affiliation info available
Nestler JE
No affiliation info available

MeSH

AdolescentAdultCardiovascular DiseasesDiabetes Mellitus, Type 2Evidence-Based MedicineFemaleHumansMetabolic SyndromePolycystic Ovary SyndromePrevalenceRisk Factors

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17304037

Citation

Essah, Paulina A., et al. "The Metabolic Syndrome in Polycystic Ovary Syndrome." Clinical Obstetrics and Gynecology, vol. 50, no. 1, 2007, pp. 205-25.
Essah PA, Wickham EP, Nestler JE. The metabolic syndrome in polycystic ovary syndrome. Clin Obstet Gynecol. 2007;50(1):205-25.
Essah, P. A., Wickham, E. P., & Nestler, J. E. (2007). The metabolic syndrome in polycystic ovary syndrome. Clinical Obstetrics and Gynecology, 50(1), 205-25.
Essah PA, Wickham EP, Nestler JE. The Metabolic Syndrome in Polycystic Ovary Syndrome. Clin Obstet Gynecol. 2007;50(1):205-25. PubMed PMID: 17304037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The metabolic syndrome in polycystic ovary syndrome. AU - Essah,Paulina A, AU - Wickham,Edmond P, AU - Nestler,John E, PY - 2007/2/17/pubmed PY - 2007/4/18/medline PY - 2007/2/17/entrez SP - 205 EP - 25 JF - Clinical obstetrics and gynecology JO - Clin Obstet Gynecol VL - 50 IS - 1 N2 - Approximately one-third to one-half of all women and adolescent girls with polycystic ovary syndrome (PCOS) has the metabolic syndrome, associated with increased risk for cardiovascular disease and type 2 diabetes. Evidence suggests that insulin resistance is the likely link between PCOS and the metabolic syndrome. Early screening for impaired glucose tolerance, even in adolescents, is recommended. Lifestyle modification with increased physical activity and weight reduction remains first-line therapy. Insulin-sensitizing drugs may also ameliorate features of the metabolic syndrome in PCOS but long-term prospective studies are needed to determine the role of these drugs in the prevention of the metabolic syndrome. SN - 0009-9201 UR - https://www.unboundmedicine.com/medline/citation/17304037/The_metabolic_syndrome_in_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -