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Ovulation induction management of PCOS.
Clin Obstet Gynecol. 2007 Mar; 50(1):255-67.CO

Abstract

Ovulation induction is the principal infertility treatment for women with polycystic ovarian syndrome (PCOS). Among PCOS patients who are overweight or obese, weight loss is the most physiologic method of inducing ovulation. For women in whom weight loss is not possible, or for lean women with PCOS, clomiphene citrate is an effective first-line method of ovulation induction. In clomiphene-resistant women, alternative treatments include adjunctive metformin or dexamethasone, aromatase inhibitors, or ovarian drilling. If there is no pregnancy despite several cycles of successful ovulation induction, gonadotropin treatment should be considered, in which case in vitro fertilization is recommended as the safest and most effective strategy.

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Authors+Show Affiliations

Guzick DS
University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. david_guzick@urmc.rochester.edu

MeSH

Aromatase InhibitorsClomipheneEndometrial NeoplasmsFemaleFertility Agents, FemaleGlucocorticoidsGonadotropinsGynecologic Surgical ProceduresHumansInfertility, FemaleMetforminObesityOvaryOvulation InductionPolycystic Ovary SyndromePregnancyPregnancy RateWeight Loss

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17304040

Citation

Guzick, David S.. "Ovulation Induction Management of PCOS." Clinical Obstetrics and Gynecology, vol. 50, no. 1, 2007, pp. 255-67.
Guzick DS. Ovulation induction management of PCOS. Clin Obstet Gynecol. 2007;50(1):255-67.
Guzick, D. S. (2007). Ovulation induction management of PCOS. Clinical Obstetrics and Gynecology, 50(1), 255-67.
Guzick DS. Ovulation Induction Management of PCOS. Clin Obstet Gynecol. 2007;50(1):255-67. PubMed PMID: 17304040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ovulation induction management of PCOS. A1 - Guzick,David S, PY - 2007/2/17/pubmed PY - 2007/4/18/medline PY - 2007/2/17/entrez SP - 255 EP - 67 JF - Clinical obstetrics and gynecology JO - Clin Obstet Gynecol VL - 50 IS - 1 N2 - Ovulation induction is the principal infertility treatment for women with polycystic ovarian syndrome (PCOS). Among PCOS patients who are overweight or obese, weight loss is the most physiologic method of inducing ovulation. For women in whom weight loss is not possible, or for lean women with PCOS, clomiphene citrate is an effective first-line method of ovulation induction. In clomiphene-resistant women, alternative treatments include adjunctive metformin or dexamethasone, aromatase inhibitors, or ovarian drilling. If there is no pregnancy despite several cycles of successful ovulation induction, gonadotropin treatment should be considered, in which case in vitro fertilization is recommended as the safest and most effective strategy. SN - 0009-9201 UR - https://www.unboundmedicine.com/medline/citation/17304040/Ovulation_induction_management_of_PCOS_ L2 - https://dx.doi.org/10.1097/GRF.0b013e31802f361e DB - PRIME DP - Unbound Medicine ER -