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Comparison of deltaFVC between patients with allergic rhinitis with airway hypersensitivity and patients with mild asthma.
Ann Allergy Asthma Immunol. 2007 Feb; 98(2):128-33.AA

Abstract

BACKGROUND

In asthmatic individuals, airway sensitivity and maximal airway response are increased. Airway sensitivity is usually evaluated by measuring the provocation concentration of inhaled methacholine or histamine that causes a decrease in forced expiratory volume in 1 second of 20% (PC20). The percentage decrease in forced vital capacity at the PC20 (deltaFVC) has been proposed as a surrogate marker for maximal airway response. Individuals with allergic rhinitis and no clinical evidence of asthma frequently exhibit airway hypersensitivity.

OBJECTIVE

To compare the deltaFVC between patients with allergic rhinitis and mild asthmatic patients with a similar degree of airway hypersensitivity.

METHODS

A retrospective analysis of methacholine challenge test data from 72 children with allergic rhinitis and airway hypersensitivity (methacholine PC20 < 16 mg/mL) (rhinitis group) and from 72 children with mild atopic asthma matched to the rhinitis group regarding the methacholine PC20 (asthma group). The deltaFVC was calculated on the concentration-response curve to methacholine.

RESULTS

The mean +/- SD deltaFVC was significantly lower in the rhinitis group (15.0% +/- 3.6%) vs the asthma group (17.4% +/- 5.3%) (P = .002). There was no significant correlation between the deltaFVC and PC20 in the rhinitis (r = -0.101; P = .41) and asthma (r = -0.023; P = .85) groups when 2 patients with PC20 less than 1 mg/mL were excluded from each group.

CONCLUSIONS

Patients with allergic rhinitis and airway hypersensitivity had a significantly lower deltaFVC than methacholine PC20-matched mild asthmatic patients, suggesting that the level of maximal airway response in patients with allergic rhinitis is lower than that in mild asthmatic patients with a similar degree of airway hypersensitivity.

Authors+Show Affiliations

Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17304878

Citation

Choi, Sun Hee, et al. "Comparison of deltaFVC Between Patients With Allergic Rhinitis With Airway Hypersensitivity and Patients With Mild Asthma." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 98, no. 2, 2007, pp. 128-33.
Choi SH, Kim DK, Yoo Y, et al. Comparison of deltaFVC between patients with allergic rhinitis with airway hypersensitivity and patients with mild asthma. Ann Allergy Asthma Immunol. 2007;98(2):128-33.
Choi, S. H., Kim, D. K., Yoo, Y., Yu, J., & Koh, Y. Y. (2007). Comparison of deltaFVC between patients with allergic rhinitis with airway hypersensitivity and patients with mild asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 98(2), 128-33.
Choi SH, et al. Comparison of deltaFVC Between Patients With Allergic Rhinitis With Airway Hypersensitivity and Patients With Mild Asthma. Ann Allergy Asthma Immunol. 2007;98(2):128-33. PubMed PMID: 17304878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of deltaFVC between patients with allergic rhinitis with airway hypersensitivity and patients with mild asthma. AU - Choi,Sun Hee, AU - Kim,Do Kyun, AU - Yoo,Young, AU - Yu,Jinho, AU - Koh,Young Yull, PY - 2007/2/20/pubmed PY - 2007/3/14/medline PY - 2007/2/20/entrez SP - 128 EP - 33 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 98 IS - 2 N2 - BACKGROUND: In asthmatic individuals, airway sensitivity and maximal airway response are increased. Airway sensitivity is usually evaluated by measuring the provocation concentration of inhaled methacholine or histamine that causes a decrease in forced expiratory volume in 1 second of 20% (PC20). The percentage decrease in forced vital capacity at the PC20 (deltaFVC) has been proposed as a surrogate marker for maximal airway response. Individuals with allergic rhinitis and no clinical evidence of asthma frequently exhibit airway hypersensitivity. OBJECTIVE: To compare the deltaFVC between patients with allergic rhinitis and mild asthmatic patients with a similar degree of airway hypersensitivity. METHODS: A retrospective analysis of methacholine challenge test data from 72 children with allergic rhinitis and airway hypersensitivity (methacholine PC20 < 16 mg/mL) (rhinitis group) and from 72 children with mild atopic asthma matched to the rhinitis group regarding the methacholine PC20 (asthma group). The deltaFVC was calculated on the concentration-response curve to methacholine. RESULTS: The mean +/- SD deltaFVC was significantly lower in the rhinitis group (15.0% +/- 3.6%) vs the asthma group (17.4% +/- 5.3%) (P = .002). There was no significant correlation between the deltaFVC and PC20 in the rhinitis (r = -0.101; P = .41) and asthma (r = -0.023; P = .85) groups when 2 patients with PC20 less than 1 mg/mL were excluded from each group. CONCLUSIONS: Patients with allergic rhinitis and airway hypersensitivity had a significantly lower deltaFVC than methacholine PC20-matched mild asthmatic patients, suggesting that the level of maximal airway response in patients with allergic rhinitis is lower than that in mild asthmatic patients with a similar degree of airway hypersensitivity. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/17304878/Comparison_of_deltaFVC_between_patients_with_allergic_rhinitis_with_airway_hypersensitivity_and_patients_with_mild_asthma_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=17304878.ui DB - PRIME DP - Unbound Medicine ER -