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Comparison of inter-twin concordance in symptoms of temporomandibular disorders: a preliminary investigation in an adolescent twin population.
Cranio. 2007 Jan; 25(1):23-9.C

Abstract

There is controversy as to the genetic contribution to the pathogenesis of temporo-mandibular disorders (TMD). Several reports reveal a marked familial aggregation in the signs and symptoms of TMD, while others do not. Therefore, our goal was to investigate the hypothesis using a sophisticated research design, which was a well-known genetic survey inter-twin concordance assessment in the symptoms of TMD. This study is the first step to survey TMD symptoms of a twin group in junior and high schools as a preliminary trial. The 63 twins were asked to participate in this study in junior and senior high schools affiliated with the University of Tokyo, Japan, schools which kept ten twins in each grade for the purpose of several genetic survey programs. After excluding incomplete filling out of questionnaire sheets and data from male-female pairs, 43 monozygotic (MZ) (15.3+/-1.7 yrs, male/female = 17/26 pairs) and nine dyzygotic (DZ) (15.2+/-1.8 yrs, male/female = 6/3 pairs) twins were studied. Outcomes consisted of a prevalidated 14-item self-administered questionnaire, which assessed proband- and pair-wise concordance levels in the MZ and DZ twins. These results demonstrated that the MZ twins had a higher tendency of inter-twin concordance than DZ twins in terms of jaw pain in wide mouth opening (proband-wise concordance = 66.7% in MZ, 0% in DZ), difficulty in mouth opening (20% in MZ, 0% in DZ) and difficulty in mouth closing (50.0% in MZ, 33.3% in DZ), while there was no significant difference between the MZ and DZ concordance levels in other general health-related and behavior-related items, except toothache. However, the pair-wise concordance rates of jaw pain in wide mouth opening and difficulty in mouth opening in the MZ twins were not significantly higher compared to the DZ rate. Possibly, a genetic factor contributed to the pathogenesis of TMD in an adolescent population. The sample size needs to be increased, and there are plans to survey the next sample in the same schools.

Authors+Show Affiliations

School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

17304914

Citation

Matsuka, Yoshizo, et al. "Comparison of Inter-twin Concordance in Symptoms of Temporomandibular Disorders: a Preliminary Investigation in an Adolescent Twin Population." Cranio : the Journal of Craniomandibular Practice, vol. 25, no. 1, 2007, pp. 23-9.
Matsuka Y, Nagamatsu C, Itoh S, et al. Comparison of inter-twin concordance in symptoms of temporomandibular disorders: a preliminary investigation in an adolescent twin population. Cranio. 2007;25(1):23-9.
Matsuka, Y., Nagamatsu, C., Itoh, S., Tomonari, T., Makki, A., Minakuchi, H., Maekawa, K., Kanyama, M., & Kuboki, T. (2007). Comparison of inter-twin concordance in symptoms of temporomandibular disorders: a preliminary investigation in an adolescent twin population. Cranio : the Journal of Craniomandibular Practice, 25(1), 23-9.
Matsuka Y, et al. Comparison of Inter-twin Concordance in Symptoms of Temporomandibular Disorders: a Preliminary Investigation in an Adolescent Twin Population. Cranio. 2007;25(1):23-9. PubMed PMID: 17304914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of inter-twin concordance in symptoms of temporomandibular disorders: a preliminary investigation in an adolescent twin population. AU - Matsuka,Yoshizo, AU - Nagamatsu,Chiyomi, AU - Itoh,Shingo, AU - Tomonari,Takayuki, AU - Makki,Ali, AU - Minakuchi,Hajime, AU - Maekawa,Kenji, AU - Kanyama,Manabu, AU - Kuboki,Takuo, PY - 2007/2/20/pubmed PY - 2007/3/7/medline PY - 2007/2/20/entrez SP - 23 EP - 9 JF - Cranio : the journal of craniomandibular practice JO - Cranio VL - 25 IS - 1 N2 - There is controversy as to the genetic contribution to the pathogenesis of temporo-mandibular disorders (TMD). Several reports reveal a marked familial aggregation in the signs and symptoms of TMD, while others do not. Therefore, our goal was to investigate the hypothesis using a sophisticated research design, which was a well-known genetic survey inter-twin concordance assessment in the symptoms of TMD. This study is the first step to survey TMD symptoms of a twin group in junior and high schools as a preliminary trial. The 63 twins were asked to participate in this study in junior and senior high schools affiliated with the University of Tokyo, Japan, schools which kept ten twins in each grade for the purpose of several genetic survey programs. After excluding incomplete filling out of questionnaire sheets and data from male-female pairs, 43 monozygotic (MZ) (15.3+/-1.7 yrs, male/female = 17/26 pairs) and nine dyzygotic (DZ) (15.2+/-1.8 yrs, male/female = 6/3 pairs) twins were studied. Outcomes consisted of a prevalidated 14-item self-administered questionnaire, which assessed proband- and pair-wise concordance levels in the MZ and DZ twins. These results demonstrated that the MZ twins had a higher tendency of inter-twin concordance than DZ twins in terms of jaw pain in wide mouth opening (proband-wise concordance = 66.7% in MZ, 0% in DZ), difficulty in mouth opening (20% in MZ, 0% in DZ) and difficulty in mouth closing (50.0% in MZ, 33.3% in DZ), while there was no significant difference between the MZ and DZ concordance levels in other general health-related and behavior-related items, except toothache. However, the pair-wise concordance rates of jaw pain in wide mouth opening and difficulty in mouth opening in the MZ twins were not significantly higher compared to the DZ rate. Possibly, a genetic factor contributed to the pathogenesis of TMD in an adolescent population. The sample size needs to be increased, and there are plans to survey the next sample in the same schools. SN - 0886-9634 UR - https://www.unboundmedicine.com/medline/citation/17304914/Comparison_of_inter_twin_concordance_in_symptoms_of_temporomandibular_disorders:_a_preliminary_investigation_in_an_adolescent_twin_population_ L2 - http://www.tandfonline.com/doi/full/10.1179/crn.2007.005 DB - PRIME DP - Unbound Medicine ER -