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Deep dermatophytosis caused by Trichophyton rubrum: report of two cases.
Mycoses. 2007 Mar; 50(2):102-8.M

Abstract

Two patients presenting with subcutaneous nodules, plaques, papules and ulceration caused by Trichophyton rubrum are described in this report. The first case was a 46-year-old woman referred with erythema and desquamation over her trunk, hands and feet for 30 years, progressing to nodules and ulceration over her trunk, arms and scalp for the last 2 years. The second case was a 34-year-old man who presented with a 2-year-history of itchy, erythema and desquamation over the trunk, progressing to papules, nodules and cyst around his ear, on the neck and scalp for 1 year. The diagnoses were suspected after direct microscopical examinations of the discharge materials, which revealed the presence of hyaline hyphae. The histological examinations showed granulomatous inflammatory infiltrates with fungal elements in the dermis including epithelioid cells, giant cells, lymphocytes and eosinophils, and the periodic acid-Schiff stain showed hypha within the granulomas. Cultures of puncture materials, skin biopsies and nails confirmed the diagnosis identifying T. rubrum. Antifungal therapies with itraconazole were successful in both patients, the lesions were completely clear with atrophic scars after 3 months. Side effects were not noticed during the medication. We discuss the clinical types of granulomatous cutaneous lesions caused by dermatophyte infections and evaluate the therapeutic effect of itraconazole.

Authors+Show Affiliations

Institute of Dermatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Nanjing, China. juanqingong@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17305772

Citation

Gong, J Q., et al. "Deep Dermatophytosis Caused By Trichophyton Rubrum: Report of Two Cases." Mycoses, vol. 50, no. 2, 2007, pp. 102-8.
Gong JQ, Liu XQ, Xu HB, et al. Deep dermatophytosis caused by Trichophyton rubrum: report of two cases. Mycoses. 2007;50(2):102-8.
Gong, J. Q., Liu, X. Q., Xu, H. B., Zeng, X. S., Chen, W., & Li, X. F. (2007). Deep dermatophytosis caused by Trichophyton rubrum: report of two cases. Mycoses, 50(2), 102-8.
Gong JQ, et al. Deep Dermatophytosis Caused By Trichophyton Rubrum: Report of Two Cases. Mycoses. 2007;50(2):102-8. PubMed PMID: 17305772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deep dermatophytosis caused by Trichophyton rubrum: report of two cases. AU - Gong,J Q, AU - Liu,X Q, AU - Xu,H B, AU - Zeng,X S, AU - Chen,W, AU - Li,X F, PY - 2007/2/20/pubmed PY - 2007/5/18/medline PY - 2007/2/20/entrez SP - 102 EP - 8 JF - Mycoses JO - Mycoses VL - 50 IS - 2 N2 - Two patients presenting with subcutaneous nodules, plaques, papules and ulceration caused by Trichophyton rubrum are described in this report. The first case was a 46-year-old woman referred with erythema and desquamation over her trunk, hands and feet for 30 years, progressing to nodules and ulceration over her trunk, arms and scalp for the last 2 years. The second case was a 34-year-old man who presented with a 2-year-history of itchy, erythema and desquamation over the trunk, progressing to papules, nodules and cyst around his ear, on the neck and scalp for 1 year. The diagnoses were suspected after direct microscopical examinations of the discharge materials, which revealed the presence of hyaline hyphae. The histological examinations showed granulomatous inflammatory infiltrates with fungal elements in the dermis including epithelioid cells, giant cells, lymphocytes and eosinophils, and the periodic acid-Schiff stain showed hypha within the granulomas. Cultures of puncture materials, skin biopsies and nails confirmed the diagnosis identifying T. rubrum. Antifungal therapies with itraconazole were successful in both patients, the lesions were completely clear with atrophic scars after 3 months. Side effects were not noticed during the medication. We discuss the clinical types of granulomatous cutaneous lesions caused by dermatophyte infections and evaluate the therapeutic effect of itraconazole. SN - 0933-7407 UR - https://www.unboundmedicine.com/medline/citation/17305772/Deep_dermatophytosis_caused_by_Trichophyton_rubrum:_report_of_two_cases_ L2 - https://doi.org/10.1111/j.1439-0507.2006.01324.x DB - PRIME DP - Unbound Medicine ER -