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Predictors of immunity after hepatitis A vaccination in HIV-infected persons.
J Viral Hepat. 2007 Mar; 14(3):189-93.JV

Abstract

Hepatitis A virus (HAV) infection remains a health risk for human immunodeficiency virus (HIV)-infected persons. While the inactivated HAV vaccine affords protection to immunocompetent persons >95% of the time, rates of developing protective antibody (anti-HAV) in HIV+ persons are considerably lower. Although low CD4+ T-cell counts have previously been reported to be correlated with this poor response, the effect of HIV viraemia on HAV vaccine response has not previously been reported. The medical records of HIV-infected patients who had received at least one dose of HAV vaccine (Havrix, 1440 EIU) were reviewed for factors associated with the development of a protective anti-HAV response. Serological data with regard to anti-HAV status after vaccination were available in 238 patients with 133 individuals (49.6%) developing immunity after vaccination. In a logistic regression model, the only factors associated with a protective antibody response were an HIV plasma RNA level <1000 copies/mL at the time of vaccination (P = 0.011) and male gender (P = 0.016). Neither nadir CD4+ T cell count nor CD4+ T-cell count at time of vaccination were predictive of the development of anti-HAV. Suppression of HIV replication at time of vaccination is associated with a protective antibody response to HAV vaccination in HIV-infected adults. The low rate of response warrants further research in alternative strategies for HAV vaccination among HIV-infected persons.

Authors+Show Affiliations

Washington University School of Medicine, St Louis, MO, USA. toverton@im.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17305885

Citation

Overton, E T., et al. "Predictors of Immunity After Hepatitis a Vaccination in HIV-infected Persons." Journal of Viral Hepatitis, vol. 14, no. 3, 2007, pp. 189-93.
Overton ET, Nurutdinova D, Sungkanuparph S, et al. Predictors of immunity after hepatitis A vaccination in HIV-infected persons. J Viral Hepat. 2007;14(3):189-93.
Overton, E. T., Nurutdinova, D., Sungkanuparph, S., Seyfried, W., Groger, R. K., & Powderly, W. G. (2007). Predictors of immunity after hepatitis A vaccination in HIV-infected persons. Journal of Viral Hepatitis, 14(3), 189-93.
Overton ET, et al. Predictors of Immunity After Hepatitis a Vaccination in HIV-infected Persons. J Viral Hepat. 2007;14(3):189-93. PubMed PMID: 17305885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of immunity after hepatitis A vaccination in HIV-infected persons. AU - Overton,E T, AU - Nurutdinova,D, AU - Sungkanuparph,S, AU - Seyfried,W, AU - Groger,R K, AU - Powderly,W G, PY - 2007/2/20/pubmed PY - 2007/8/28/medline PY - 2007/2/20/entrez SP - 189 EP - 93 JF - Journal of viral hepatitis JO - J Viral Hepat VL - 14 IS - 3 N2 - Hepatitis A virus (HAV) infection remains a health risk for human immunodeficiency virus (HIV)-infected persons. While the inactivated HAV vaccine affords protection to immunocompetent persons >95% of the time, rates of developing protective antibody (anti-HAV) in HIV+ persons are considerably lower. Although low CD4+ T-cell counts have previously been reported to be correlated with this poor response, the effect of HIV viraemia on HAV vaccine response has not previously been reported. The medical records of HIV-infected patients who had received at least one dose of HAV vaccine (Havrix, 1440 EIU) were reviewed for factors associated with the development of a protective anti-HAV response. Serological data with regard to anti-HAV status after vaccination were available in 238 patients with 133 individuals (49.6%) developing immunity after vaccination. In a logistic regression model, the only factors associated with a protective antibody response were an HIV plasma RNA level <1000 copies/mL at the time of vaccination (P = 0.011) and male gender (P = 0.016). Neither nadir CD4+ T cell count nor CD4+ T-cell count at time of vaccination were predictive of the development of anti-HAV. Suppression of HIV replication at time of vaccination is associated with a protective antibody response to HAV vaccination in HIV-infected adults. The low rate of response warrants further research in alternative strategies for HAV vaccination among HIV-infected persons. SN - 1352-0504 UR - https://www.unboundmedicine.com/medline/citation/17305885/Predictors_of_immunity_after_hepatitis_A_vaccination_in_HIV_infected_persons_ DB - PRIME DP - Unbound Medicine ER -