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The influence of folic acid, vitamins B(2) and B(6) supplementation on feed intake, body and organs weight, and liver fatty acids composition of rats subjected to 3 months moderate protein deprivation.

Abstract

This study was conducted to determine the effect of a 3-month dietary protein restriction - protein provided 9% of energy (20% in control group). In this dietary restriction folic acid, vitamins B(2) and B(6) were delivered in amount three times above the standard level. It was observed that animals fed a protein restricted (PR) diet weighed about 5% less than animals consuming adequate diet, but the difference was not statistically significant. Enrichment of PR diet with vitamin B or folic acid caused tendency to further suppression of weight gain, and in case of vitamin B(6) these differences were statistically significant. However, such body weight (BW) suppression was not observed when all studied vitamins were used together. Significant reductions in relative liver weight (vitamin B(2) addition), the heart (folic acid) and the lungs (vitamin B(6)) were observed. The PR diet, when all vitamins were added together, caused a decrease in weights of the lungs, heart and liver scaled to BW of rats, simultaneously with a significant increase in testis weight. Feed intake and feed conversion ratio were higher in animals given PR diet without a significant influence of vitamin supplementation (except vitamin B(6) causing further increase in feed conversion ratio). Hepatic fatty acids composition of rats was not affected by protein restriction, as well as by single vitamin supplementation. However, dietary supplementation of all examined vitamins together caused a decrease in monounsaturated fatty acids followed by an increase in polyunsaturated fatty acids participation in total fatty acids pool. It seems that enrichment of PR diet with a mixture of folic acid, vitamins B(2) and B(6) resulted in a partial reverse of growth suppression and reduction in testis size in rats.

Authors+Show Affiliations

Department of Physiological Sciences, Veterinary Medicine Faculty, Warsaw Agricultural University, Warsaw, Poland. debski@alpha.sggw.waw.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17305966

Citation

Debski, B, et al. "The Influence of Folic Acid, Vitamins B(2) and B(6) Supplementation On Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 Months Moderate Protein Deprivation." Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine, vol. 54, no. 2, 2007, pp. 57-61.
Debski B, Bertrandt J, Klos A, et al. The influence of folic acid, vitamins B(2) and B(6) supplementation on feed intake, body and organs weight, and liver fatty acids composition of rats subjected to 3 months moderate protein deprivation. J Vet Med A Physiol Pathol Clin Med. 2007;54(2):57-61.
Debski, B., Bertrandt, J., Klos, A., & Gralak, M. (2007). The influence of folic acid, vitamins B(2) and B(6) supplementation on feed intake, body and organs weight, and liver fatty acids composition of rats subjected to 3 months moderate protein deprivation. Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine, 54(2), pp. 57-61.
Debski B, et al. The Influence of Folic Acid, Vitamins B(2) and B(6) Supplementation On Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 Months Moderate Protein Deprivation. J Vet Med A Physiol Pathol Clin Med. 2007;54(2):57-61. PubMed PMID: 17305966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of folic acid, vitamins B(2) and B(6) supplementation on feed intake, body and organs weight, and liver fatty acids composition of rats subjected to 3 months moderate protein deprivation. AU - Debski,B, AU - Bertrandt,J, AU - Klos,A, AU - Gralak,M, PY - 2007/2/20/pubmed PY - 2007/5/8/medline PY - 2007/2/20/entrez SP - 57 EP - 61 JF - Journal of veterinary medicine. A, Physiology, pathology, clinical medicine JO - J Vet Med A Physiol Pathol Clin Med VL - 54 IS - 2 N2 - This study was conducted to determine the effect of a 3-month dietary protein restriction - protein provided 9% of energy (20% in control group). In this dietary restriction folic acid, vitamins B(2) and B(6) were delivered in amount three times above the standard level. It was observed that animals fed a protein restricted (PR) diet weighed about 5% less than animals consuming adequate diet, but the difference was not statistically significant. Enrichment of PR diet with vitamin B or folic acid caused tendency to further suppression of weight gain, and in case of vitamin B(6) these differences were statistically significant. However, such body weight (BW) suppression was not observed when all studied vitamins were used together. Significant reductions in relative liver weight (vitamin B(2) addition), the heart (folic acid) and the lungs (vitamin B(6)) were observed. The PR diet, when all vitamins were added together, caused a decrease in weights of the lungs, heart and liver scaled to BW of rats, simultaneously with a significant increase in testis weight. Feed intake and feed conversion ratio were higher in animals given PR diet without a significant influence of vitamin supplementation (except vitamin B(6) causing further increase in feed conversion ratio). Hepatic fatty acids composition of rats was not affected by protein restriction, as well as by single vitamin supplementation. However, dietary supplementation of all examined vitamins together caused a decrease in monounsaturated fatty acids followed by an increase in polyunsaturated fatty acids participation in total fatty acids pool. It seems that enrichment of PR diet with a mixture of folic acid, vitamins B(2) and B(6) resulted in a partial reverse of growth suppression and reduction in testis size in rats. SN - 0931-184X UR - https://www.unboundmedicine.com/medline/citation/17305966/The_influence_of_folic_acid_vitamins_B_2__and_B_6__supplementation_on_feed_intake_body_and_organs_weight_and_liver_fatty_acids_composition_of_rats_subjected_to_3_months_moderate_protein_deprivation_ L2 - https://doi.org/10.1111/j.1439-0442.2007.00904.x DB - PRIME DP - Unbound Medicine ER -