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RETRACTED ARTICLE

Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease.
J Neurol Sci. 2007 Mar 15; 254(1-2):72-7.JN

Abstract

OBJECTIVE

We estimated the extent and pattern of cardiovascular autonomic dysfunction in dementia with Lewy bodies (DLB) as compared with that in Parkinson's disease (PD).

METHODS

We performed meta-iodobenzylguanidine ((123)I-MIBG) scintigraphy of the heart and hemodynamic autonomic function testing using the Valsalva maneuver in 27 patients with DLB, 46 with PD, and 20 controls.

RESULTS

(123)I-MIBG uptakes in DLB were reduced as compared with those in control and PD. Hemodynamic studies revealed that DLB had decreased baroreceptor reflex and reduced responses of SBP in phases II and IV as compared with PD and control. SBP responses on standing and the difference in plasma norepinephrine (NE) concentrations between supine and standing positions were reduced in PD as compared with those in control. Furthermore, SBP responses on standing, plasma NE concentrations in supine and standing positions, and the difference in plasma NE concentrations between these positions were significantly lower in DLB than in PD and control. Plasma NE concentrations in DLB with orthostatic hypotension (OH) were lower than that in DLB without OH, although some patients who had DLB with orthostatic hypotension had relatively normal plasma NE levels.

CONCLUSION

Cardiovascular autonomic dysfunction is more severe in DLB than in PD and is usually caused by the loss of postganglionic sympathetic nervous function, although dysautonomia in some patients with DLB may result from preganglionic dysfunction.

Authors+Show Affiliations

Department of Neurology, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Tokyo, 105-8461, Japan. h.oka@jikei.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Retracted Publication

Language

eng

PubMed ID

17306830

Citation

Oka, Hisayoshi, et al. "Cardiovascular Autonomic Dysfunction in Dementia With Lewy Bodies and Parkinson's Disease." Journal of the Neurological Sciences, vol. 254, no. 1-2, 2007, pp. 72-7.
Oka H, Morita M, Onouchi K, et al. Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease. J Neurol Sci. 2007;254(1-2):72-7.
Oka, H., Morita, M., Onouchi, K., Yoshioka, M., Mochio, S., & Inoue, K. (2007). Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease. Journal of the Neurological Sciences, 254(1-2), 72-7.
Oka H, et al. Cardiovascular Autonomic Dysfunction in Dementia With Lewy Bodies and Parkinson's Disease. J Neurol Sci. 2007 Mar 15;254(1-2):72-7. PubMed PMID: 17306830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease. AU - Oka,Hisayoshi, AU - Morita,Masayo, AU - Onouchi,Kenji, AU - Yoshioka,Masayuki, AU - Mochio,Soichiro, AU - Inoue,Kiyoharu, Y1 - 2007/02/15/ PY - 2006/07/29/received PY - 2006/10/15/revised PY - 2007/01/03/accepted PY - 2007/2/20/pubmed PY - 2007/5/30/medline PY - 2007/2/20/entrez SP - 72 EP - 7 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 254 IS - 1-2 N2 - OBJECTIVE: We estimated the extent and pattern of cardiovascular autonomic dysfunction in dementia with Lewy bodies (DLB) as compared with that in Parkinson's disease (PD). METHODS: We performed meta-iodobenzylguanidine ((123)I-MIBG) scintigraphy of the heart and hemodynamic autonomic function testing using the Valsalva maneuver in 27 patients with DLB, 46 with PD, and 20 controls. RESULTS: (123)I-MIBG uptakes in DLB were reduced as compared with those in control and PD. Hemodynamic studies revealed that DLB had decreased baroreceptor reflex and reduced responses of SBP in phases II and IV as compared with PD and control. SBP responses on standing and the difference in plasma norepinephrine (NE) concentrations between supine and standing positions were reduced in PD as compared with those in control. Furthermore, SBP responses on standing, plasma NE concentrations in supine and standing positions, and the difference in plasma NE concentrations between these positions were significantly lower in DLB than in PD and control. Plasma NE concentrations in DLB with orthostatic hypotension (OH) were lower than that in DLB without OH, although some patients who had DLB with orthostatic hypotension had relatively normal plasma NE levels. CONCLUSION: Cardiovascular autonomic dysfunction is more severe in DLB than in PD and is usually caused by the loss of postganglionic sympathetic nervous function, although dysautonomia in some patients with DLB may result from preganglionic dysfunction. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/17306830/Cardiovascular_autonomic_dysfunction_in_dementia_with_Lewy_bodies_and_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(07)00023-8 DB - PRIME DP - Unbound Medicine ER -