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Comparison of dietary triacylglycerol oil and diacylglycerol oil in protein kinase C activation.
Food Chem Toxicol. 2007 Jul; 45(7):1165-72.FC

Abstract

The objective of the present study was to compare the effects of dietary diacylglycerol (DAG) oil with triacylglycerol (TAG) oil with a similar fatty acid composition (fatty acid chain range: C14-C22, C18 fatty acid chain: >90%) on protein kinase C (PKC) activation and on 1,2-DAG levels. Using male Wistar rats, no differences in cytosolic and membrane PKC activities in the lingual, esophageal, gastric, small intestinal, cecal, proximal colonic, and distal colonic mucosa were found between the 5% DAG and TAG oil groups, or between the 23% DAG and TAG oil groups after 1 month of feeding. The 1,2-DAG levels in the cecum and colon contents and in the feces and serum in male Wistar rats after a diet containing either 10% DAG or TAG oil feeding were similar between the groups. Moreover, exposure of Caco-2 cells to DAG and TAG oils had no effect on PKC activity in the membrane fraction, but 1,2-dioctanoyl glycerol composed of short-chain fatty acids (C8) did, suggesting the absence of an influence on PKC activity in DAG and TAG oils composed of long-chain fatty acids. In summary, the effects of DAG oil ingestion on PKC activity in the digestive tract and lingual mucosa, and on 1,2-DAG levels in the cecum and colon contents and in the feces and serum were similar to those observed for TAG oil ingestion.

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Authors+Show Affiliations

Meguro S
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikaimachi, Haga, Tochigi 321-3497, Japan. meguro.shinichi@kao.co.jp
Osaki N
No affiliation info available
Onizawa K
No affiliation info available
Yajima N
No affiliation info available
Hase T
No affiliation info available
Matsuo N
No affiliation info available
Tokimitsu I
No affiliation info available

MeSH

AnimalsCaco-2 CellsCell MembraneCytosolDietary FatsDiglyceridesDose-Response Relationship, DrugEnzyme ActivationFecesGastrointestinal TractHumansMaleProtein Kinase CRatsRats, WistarTriglycerides

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17306914

Citation

Meguro, Shinichi, et al. "Comparison of Dietary Triacylglycerol Oil and Diacylglycerol Oil in Protein Kinase C Activation." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 45, no. 7, 2007, pp. 1165-72.
Meguro S, Osaki N, Onizawa K, et al. Comparison of dietary triacylglycerol oil and diacylglycerol oil in protein kinase C activation. Food Chem Toxicol. 2007;45(7):1165-72.
Meguro, S., Osaki, N., Onizawa, K., Yajima, N., Hase, T., Matsuo, N., & Tokimitsu, I. (2007). Comparison of dietary triacylglycerol oil and diacylglycerol oil in protein kinase C activation. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 45(7), 1165-72.
Meguro S, et al. Comparison of Dietary Triacylglycerol Oil and Diacylglycerol Oil in Protein Kinase C Activation. Food Chem Toxicol. 2007;45(7):1165-72. PubMed PMID: 17306914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of dietary triacylglycerol oil and diacylglycerol oil in protein kinase C activation. AU - Meguro,Shinichi, AU - Osaki,Noriko, AU - Onizawa,Koji, AU - Yajima,Noriyuki, AU - Hase,Tadashi, AU - Matsuo,Noboru, AU - Tokimitsu,Ichiro, Y1 - 2007/01/11/ PY - 2006/02/03/received PY - 2006/10/25/revised PY - 2006/12/22/accepted PY - 2007/2/20/pubmed PY - 2007/7/26/medline PY - 2007/2/20/entrez SP - 1165 EP - 72 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 45 IS - 7 N2 - The objective of the present study was to compare the effects of dietary diacylglycerol (DAG) oil with triacylglycerol (TAG) oil with a similar fatty acid composition (fatty acid chain range: C14-C22, C18 fatty acid chain: >90%) on protein kinase C (PKC) activation and on 1,2-DAG levels. Using male Wistar rats, no differences in cytosolic and membrane PKC activities in the lingual, esophageal, gastric, small intestinal, cecal, proximal colonic, and distal colonic mucosa were found between the 5% DAG and TAG oil groups, or between the 23% DAG and TAG oil groups after 1 month of feeding. The 1,2-DAG levels in the cecum and colon contents and in the feces and serum in male Wistar rats after a diet containing either 10% DAG or TAG oil feeding were similar between the groups. Moreover, exposure of Caco-2 cells to DAG and TAG oils had no effect on PKC activity in the membrane fraction, but 1,2-dioctanoyl glycerol composed of short-chain fatty acids (C8) did, suggesting the absence of an influence on PKC activity in DAG and TAG oils composed of long-chain fatty acids. In summary, the effects of DAG oil ingestion on PKC activity in the digestive tract and lingual mucosa, and on 1,2-DAG levels in the cecum and colon contents and in the feces and serum were similar to those observed for TAG oil ingestion. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/17306914/Comparison_of_dietary_triacylglycerol_oil_and_diacylglycerol_oil_in_protein_kinase_C_activation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(07)00012-9 DB - PRIME DP - Unbound Medicine ER -