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Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer.
Cancer Lett. 2007 Aug 08; 253(1):34-42.CL

Abstract

We investigated the expression of CXC chemokine receptor 4 (CXCR4), vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 to elucidate whether these markers could predict lymph node metastasis in human breast cancer. Higher rates of CXCR4 (61%), VEGF (68%), and MMP-9 (63%) expression were found in breast cancer tissues than in normal and atypical hyperplasia tissues. The expression of these markers was significantly associated with primary tumor progression, histological grade, and lymph node status. We found there were significant correlations between the expressions of any two of the three markers (P<0.001). Furthermore, our studies indicated that concomitant expression of CXCR4/VEGF (P=0.007), CXCR4/MMP-9 (P<0.001) or VEGF/MMP-9 (P=0.003) had stronger correlation with lymph node metastasis than did each alone and that combined expression of all three makers strongly correlated with lymph node metastasis (P<0.001). Thus, simultaneously examining the expression of CXCR4, VEGF, and MMP-9 in cancer tissues of breast cancer will provide valuable prognostic diagnosis of lymph node metastasis.

Authors+Show Affiliations

Joint Immunology Laboratory of Shanghai Institute of Immunology and Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, 227 South Chongqing Road, Shanghai 200025, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17306924

Citation

Hao, Li, et al. "Recombination of CXCR4, VEGF, and MMP-9 Predicting Lymph Node Metastasis in Human Breast Cancer." Cancer Letters, vol. 253, no. 1, 2007, pp. 34-42.
Hao L, Zhang C, Qiu Y, et al. Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer. Cancer Lett. 2007;253(1):34-42.
Hao, L., Zhang, C., Qiu, Y., Wang, L., Luo, Y., Jin, M., Zhang, Y., Guo, T. B., Matsushima, K., & Zhang, Y. (2007). Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer. Cancer Letters, 253(1), 34-42.
Hao L, et al. Recombination of CXCR4, VEGF, and MMP-9 Predicting Lymph Node Metastasis in Human Breast Cancer. Cancer Lett. 2007 Aug 8;253(1):34-42. PubMed PMID: 17306924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer. AU - Hao,Li, AU - Zhang,Chunhui, AU - Qiu,Yuhua, AU - Wang,Liang, AU - Luo,Yunbao, AU - Jin,Min, AU - Zhang,Yi, AU - Guo,Taylor B, AU - Matsushima,Kouji, AU - Zhang,Yanyun, Y1 - 2007/02/16/ PY - 2006/11/23/received PY - 2006/12/31/revised PY - 2007/01/05/accepted PY - 2007/2/20/pubmed PY - 2007/8/22/medline PY - 2007/2/20/entrez SP - 34 EP - 42 JF - Cancer letters JO - Cancer Lett VL - 253 IS - 1 N2 - We investigated the expression of CXC chemokine receptor 4 (CXCR4), vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 to elucidate whether these markers could predict lymph node metastasis in human breast cancer. Higher rates of CXCR4 (61%), VEGF (68%), and MMP-9 (63%) expression were found in breast cancer tissues than in normal and atypical hyperplasia tissues. The expression of these markers was significantly associated with primary tumor progression, histological grade, and lymph node status. We found there were significant correlations between the expressions of any two of the three markers (P<0.001). Furthermore, our studies indicated that concomitant expression of CXCR4/VEGF (P=0.007), CXCR4/MMP-9 (P<0.001) or VEGF/MMP-9 (P=0.003) had stronger correlation with lymph node metastasis than did each alone and that combined expression of all three makers strongly correlated with lymph node metastasis (P<0.001). Thus, simultaneously examining the expression of CXCR4, VEGF, and MMP-9 in cancer tissues of breast cancer will provide valuable prognostic diagnosis of lymph node metastasis. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/17306924/Recombination_of_CXCR4_VEGF_and_MMP_9_predicting_lymph_node_metastasis_in_human_breast_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(07)00012-2 DB - PRIME DP - Unbound Medicine ER -