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Negative association between infra-renal aortic diameter and glycaemia: the Health in Men Study.
Eur J Vasc Endovasc Surg. 2007 May; 33(5):599-604.EJ

Abstract

OBJECTIVE

There is evidence of a negative association between diabetes and abdominal aortic aneurysm (AAA). The aim of this study was to assess whether there is a similar relationship between both diabetes and glucose level, and infra-renal aortic diameter throughout its range.

DESIGN AND METHODS

Infra-renal aortic diameter was measured using ultrasound in 12,203 men aged 65-83 years as part of a trial of screening for AAA. A range of cardiovascular risk factors were also assessed. In a follow-up study, fasting serum glucose was measured in 2,859 non-diabetic men. Aortic diameter was logarithmically transformed and treated as both a continuous and categorical variable in stepwise multivariate linear and logistic models.

RESULTS

The median aortic diameter was slightly smaller in the diabetic men (21.3+/-3.9 vs 21.6+/-3.8, P<0.0001). There was an independent negative association between diabetes and AAA (OR 0.79, 95% CI: 0.63,0.98), and an inverse correlation (Coefficient: -0.0064, p=0.0024) between fasting glucose and aortic diameter in non-diabetic men.

CONCLUSIONS

Diabetes is inversely associated with both AAA and aortic diameter in men over 65 years. This association is independent of other risk factors for AAA. Aortic diameter also has an inverse relationship with fasting glucose concentrations in men without diabetes.

Authors+Show Affiliations

School of Surgery and Pathology, The University of Western Australia, Nedlands, Western Australia, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17307366

Citation

Le, M T Q., et al. "Negative Association Between Infra-renal Aortic Diameter and Glycaemia: the Health in Men Study." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 33, no. 5, 2007, pp. 599-604.
Le MT, Jamrozik K, Davis TM, et al. Negative association between infra-renal aortic diameter and glycaemia: the Health in Men Study. Eur J Vasc Endovasc Surg. 2007;33(5):599-604.
Le, M. T., Jamrozik, K., Davis, T. M., & Norman, P. E. (2007). Negative association between infra-renal aortic diameter and glycaemia: the Health in Men Study. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 33(5), 599-604.
Le MT, et al. Negative Association Between Infra-renal Aortic Diameter and Glycaemia: the Health in Men Study. Eur J Vasc Endovasc Surg. 2007;33(5):599-604. PubMed PMID: 17307366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Negative association between infra-renal aortic diameter and glycaemia: the Health in Men Study. AU - Le,M T Q, AU - Jamrozik,K, AU - Davis,T M E, AU - Norman,P E, Y1 - 2007/02/16/ PY - 2006/10/22/received PY - 2006/12/19/accepted PY - 2007/2/20/pubmed PY - 2007/6/21/medline PY - 2007/2/20/entrez SP - 599 EP - 604 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 33 IS - 5 N2 - OBJECTIVE: There is evidence of a negative association between diabetes and abdominal aortic aneurysm (AAA). The aim of this study was to assess whether there is a similar relationship between both diabetes and glucose level, and infra-renal aortic diameter throughout its range. DESIGN AND METHODS: Infra-renal aortic diameter was measured using ultrasound in 12,203 men aged 65-83 years as part of a trial of screening for AAA. A range of cardiovascular risk factors were also assessed. In a follow-up study, fasting serum glucose was measured in 2,859 non-diabetic men. Aortic diameter was logarithmically transformed and treated as both a continuous and categorical variable in stepwise multivariate linear and logistic models. RESULTS: The median aortic diameter was slightly smaller in the diabetic men (21.3+/-3.9 vs 21.6+/-3.8, P<0.0001). There was an independent negative association between diabetes and AAA (OR 0.79, 95% CI: 0.63,0.98), and an inverse correlation (Coefficient: -0.0064, p=0.0024) between fasting glucose and aortic diameter in non-diabetic men. CONCLUSIONS: Diabetes is inversely associated with both AAA and aortic diameter in men over 65 years. This association is independent of other risk factors for AAA. Aortic diameter also has an inverse relationship with fasting glucose concentrations in men without diabetes. SN - 1078-5884 UR - https://www.unboundmedicine.com/medline/citation/17307366/Negative_association_between_infra_renal_aortic_diameter_and_glycaemia:_the_Health_in_Men_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(07)00010-X DB - PRIME DP - Unbound Medicine ER -