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Peripheral and central measurements of bone mineral density are equally strongly associated with clinical risk factors for osteoporosis.
Calcif Tissue Int. 2007 Feb; 80(2):89-96.CT

Abstract

The aim of this study was to determine whether forearm bone mineral density (BMD) measurements are affected by clinical risk factors for osteoporosis to the same extent as spine and hip BMD. The study population consisted of 1,009 female patients and volunteers, of whom 238 were premenopausal. Women were placed into seven groups according to which clinical risk factor they had (women could be placed in more than one group): (1) atraumatic fracture since the age of 25 years, (2) report of X-ray osteopenia, (3) predisposing medical condition or use of therapy known to affect bone metabolism, (4) premature menopause before the age of 45 years or a history of amenorrhea of longer than 6 months' duration, (5) family history of osteoporosis, (6) body mass index (BMI) <20 kg/m(2), and (7) current smoking habit. Forearm BMD was measured using an Osteometer DTX-200 peripheral dual-energy X-ray absorptiometry scanner, and spine and hip BMD measurements were obtained on a Hologic QDR-4500 scanner. Manufacturers' reference ranges were used to calculate Z scores for the spine and forearm, and the NHANES III reference range was used to calculate Z scores for the hip. Multivariate regression analysis was used to estimate the mean decrease in Z score associated with each clinical risk factor. The Z-score reductions associated with the seven risk factors were similar for forearm and central BMD measurements. For forearm measurements, Z-score decreases associated with a history of atraumatic fracture (-0.25), a medical condition or therapy known to affect bone metabolism (-0.26), premature menopause or history of amenorrhea (-0.30), and BMI <20 kg/m(2) (-0.82) were all statistically significantly different from zero (P < 0.05). With an increasing number of risk factors in each individual, the mean Z score at each measurement site became progressively more negative. In conclusion, clinical risk factors for low BMD affect forearm BMD measurements to a similar extent as central BMD.

Authors+Show Affiliations

Academic Bone Densitometry Unit, Imperial College London, Charing Cross Campus, St. Dunstan's Road, London W6 8RP, UK. r.patel@imperial.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

17308990

Citation

Patel, R, et al. "Peripheral and Central Measurements of Bone Mineral Density Are Equally Strongly Associated With Clinical Risk Factors for Osteoporosis." Calcified Tissue International, vol. 80, no. 2, 2007, pp. 89-96.
Patel R, Blake GM, Fogelman I. Peripheral and central measurements of bone mineral density are equally strongly associated with clinical risk factors for osteoporosis. Calcif Tissue Int. 2007;80(2):89-96.
Patel, R., Blake, G. M., & Fogelman, I. (2007). Peripheral and central measurements of bone mineral density are equally strongly associated with clinical risk factors for osteoporosis. Calcified Tissue International, 80(2), 89-96.
Patel R, Blake GM, Fogelman I. Peripheral and Central Measurements of Bone Mineral Density Are Equally Strongly Associated With Clinical Risk Factors for Osteoporosis. Calcif Tissue Int. 2007;80(2):89-96. PubMed PMID: 17308990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral and central measurements of bone mineral density are equally strongly associated with clinical risk factors for osteoporosis. AU - Patel,R, AU - Blake,G M, AU - Fogelman,I, Y1 - 2007/02/02/ PY - 2006/08/09/received PY - 2006/10/23/accepted PY - 2007/2/20/pubmed PY - 2007/5/24/medline PY - 2007/2/20/entrez SP - 89 EP - 96 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 80 IS - 2 N2 - The aim of this study was to determine whether forearm bone mineral density (BMD) measurements are affected by clinical risk factors for osteoporosis to the same extent as spine and hip BMD. The study population consisted of 1,009 female patients and volunteers, of whom 238 were premenopausal. Women were placed into seven groups according to which clinical risk factor they had (women could be placed in more than one group): (1) atraumatic fracture since the age of 25 years, (2) report of X-ray osteopenia, (3) predisposing medical condition or use of therapy known to affect bone metabolism, (4) premature menopause before the age of 45 years or a history of amenorrhea of longer than 6 months' duration, (5) family history of osteoporosis, (6) body mass index (BMI) <20 kg/m(2), and (7) current smoking habit. Forearm BMD was measured using an Osteometer DTX-200 peripheral dual-energy X-ray absorptiometry scanner, and spine and hip BMD measurements were obtained on a Hologic QDR-4500 scanner. Manufacturers' reference ranges were used to calculate Z scores for the spine and forearm, and the NHANES III reference range was used to calculate Z scores for the hip. Multivariate regression analysis was used to estimate the mean decrease in Z score associated with each clinical risk factor. The Z-score reductions associated with the seven risk factors were similar for forearm and central BMD measurements. For forearm measurements, Z-score decreases associated with a history of atraumatic fracture (-0.25), a medical condition or therapy known to affect bone metabolism (-0.26), premature menopause or history of amenorrhea (-0.30), and BMI <20 kg/m(2) (-0.82) were all statistically significantly different from zero (P < 0.05). With an increasing number of risk factors in each individual, the mean Z score at each measurement site became progressively more negative. In conclusion, clinical risk factors for low BMD affect forearm BMD measurements to a similar extent as central BMD. SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/17308990/Peripheral_and_central_measurements_of_bone_mineral_density_are_equally_strongly_associated_with_clinical_risk_factors_for_osteoporosis_ L2 - https://dx.doi.org/10.1007/s00223-006-0217-x DB - PRIME DP - Unbound Medicine ER -