TY - JOUR T1 - Plasminogen activator inhibitor -1 gene 4G/5G polymorphism in patients with breast cancer. AU - Eroglu,A, AU - Ulu,A, AU - Cam,R, AU - Akar,N, PY - 2007/2/20/pubmed PY - 2007/3/23/medline PY - 2007/2/20/entrez SP - 481 EP - 4 JF - Journal of B.U.ON. : official journal of the Balkan Union of Oncology JO - J BUON VL - 11 IS - 4 N2 - PURPOSE: The plasminogen activator inhibitor-1 (PAI-1) plays an important role in the development of tumor invasion and metastasis. The 4G allele of 4G/5G insertion / deletion polymorphism located in the promoter region 675 bp upstream from the transcription start sequence of PAI-1 gene is responsible for the higher plasma PAI-1 level. The aim of the present study was to evaluate the association between PAI-1 gene 4G / 5G polymorphism and breast cancer. MATERIALS AND METHODS: Two groups were investigated: the first group(group 1)was composed of 34 patients with breast cancer, the second group (group 2) consisted of 90 unrelated healthy women without history of malignancy. Genomic DNA isolation was performed from peripheral venous blood by standard phenol-chloroform extraction and polymerase chain reaction of the PAI-1 4G/5G polymorphism was performed. RESULTS: The prevalence of 4G/4G or 4G/5G genotype in group 1 and 2 was 97.1% and 78.8%, respectively. The distribution of the PAI-1 4G/5G genotypes was significantly different between the two groups (p<0.05). CONCLUSIONS: We suggest that this polymorphism may contribute to an inherited predisposition to the development of breast cancer, however further studies with larger series from diverse ethnic populations are needed to confirm our results. SN - 1107-0625 UR - https://www.unboundmedicine.com/medline/citation/17309181/Plasminogen_activator_inhibitor__1_gene_4G/5G_polymorphism_in_patients_with_breast_cancer_ L2 - http://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -