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Metronidazole 0.75% gel vs. ketoconazole 2% cream in the treatment of facial seborrheic dermatitis: a randomized, double-blind study.
J Eur Acad Dermatol Venereol. 2007 Mar; 21(3):345-50.JE

Abstract

BACKGROUND

Recently, two placebo-controlled studies have shown that topical metronidazole was effective in the treatment of seborrheic dermatitis.

OBJECTIVE

To compare the efficacy and safety of metronidazole 0.75% gel with that of ketoconazole 2% cream in the treatment of facial seborrheic dermatitis.

METHODS

A total of 60 consecutive patients with facial seborrheic dermatitis were included. Patients were randomized into two groups. One group used ketoconazole 2% cream with metronidazole gel as vehicle; the other group used metronidazole 0.75% gel with ketoconazole cream as vehicle for a 4-week treatment period. Main outcome measures were change in clinical severity scores, patients' and investigator's global evaluation of improvement and frequency of side-effects.

RESULTS

All the assessments were made by an investigator who was unaware of which group the patients were allocated to. Mean percentage decrease in clinical severity scores from baseline to last available visit was 63.4% (95% CI 57.7-69) and 54.4% (95% CI 47.9-61) in the ketoconazole- and metronidazole-treated patients, respectively (P = 0.31). Eighty-two per cent of patients in the ketoconazole group vs. 79% of patients in the metronidazole group rated their global improvement as significant or moderate (P > 0.05). No statistically significant difference in the frequency of side-effects was detected between the two groups. The results of this study need to be confirmed in further studies involving large numbers of patients.

CONCLUSION

Our data demonstrated that metronidazole 0.75% gel had a comparable efficacy and safety profile with that of ketoconazole 2% cream in the treatment of facial seborrheic dermatitis.

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Authors+Show Affiliations

Seckin D
Marmara University School of Medicine, Department of Dermatology, Altunizade, 34700 Uskudar/Istanbul, Turkey. seckin_dilek@yahoo.com
Gurbuz O
No affiliation info available
Akin O
No affiliation info available

MeSH

Administration, TopicalAdolescentAdultAgedAged, 80 and overAnalysis of VarianceChi-Square DistributionDermatitis, SeborrheicDermatologic AgentsDouble-Blind MethodFacial DermatosesFemaleGelsHumansKetoconazoleMaleMetronidazoleMiddle AgedOintmentsProspective StudiesTreatment Outcome

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17309456

Citation

Seckin, D, et al. "Metronidazole 0.75% Gel Vs. Ketoconazole 2% Cream in the Treatment of Facial Seborrheic Dermatitis: a Randomized, Double-blind Study." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 21, no. 3, 2007, pp. 345-50.
Seckin D, Gurbuz O, Akin O. Metronidazole 0.75% gel vs. ketoconazole 2% cream in the treatment of facial seborrheic dermatitis: a randomized, double-blind study. J Eur Acad Dermatol Venereol. 2007;21(3):345-50.
Seckin, D., Gurbuz, O., & Akin, O. (2007). Metronidazole 0.75% gel vs. ketoconazole 2% cream in the treatment of facial seborrheic dermatitis: a randomized, double-blind study. Journal of the European Academy of Dermatology and Venereology : JEADV, 21(3), 345-50.
Seckin D, Gurbuz O, Akin O. Metronidazole 0.75% Gel Vs. Ketoconazole 2% Cream in the Treatment of Facial Seborrheic Dermatitis: a Randomized, Double-blind Study. J Eur Acad Dermatol Venereol. 2007;21(3):345-50. PubMed PMID: 17309456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metronidazole 0.75% gel vs. ketoconazole 2% cream in the treatment of facial seborrheic dermatitis: a randomized, double-blind study. AU - Seckin,D, AU - Gurbuz,O, AU - Akin,O, PY - 2007/2/21/pubmed PY - 2007/7/21/medline PY - 2007/2/21/entrez SP - 345 EP - 50 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 21 IS - 3 N2 - BACKGROUND: Recently, two placebo-controlled studies have shown that topical metronidazole was effective in the treatment of seborrheic dermatitis. OBJECTIVE: To compare the efficacy and safety of metronidazole 0.75% gel with that of ketoconazole 2% cream in the treatment of facial seborrheic dermatitis. METHODS: A total of 60 consecutive patients with facial seborrheic dermatitis were included. Patients were randomized into two groups. One group used ketoconazole 2% cream with metronidazole gel as vehicle; the other group used metronidazole 0.75% gel with ketoconazole cream as vehicle for a 4-week treatment period. Main outcome measures were change in clinical severity scores, patients' and investigator's global evaluation of improvement and frequency of side-effects. RESULTS: All the assessments were made by an investigator who was unaware of which group the patients were allocated to. Mean percentage decrease in clinical severity scores from baseline to last available visit was 63.4% (95% CI 57.7-69) and 54.4% (95% CI 47.9-61) in the ketoconazole- and metronidazole-treated patients, respectively (P = 0.31). Eighty-two per cent of patients in the ketoconazole group vs. 79% of patients in the metronidazole group rated their global improvement as significant or moderate (P > 0.05). No statistically significant difference in the frequency of side-effects was detected between the two groups. The results of this study need to be confirmed in further studies involving large numbers of patients. CONCLUSION: Our data demonstrated that metronidazole 0.75% gel had a comparable efficacy and safety profile with that of ketoconazole 2% cream in the treatment of facial seborrheic dermatitis. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/17309456/Metronidazole_0_75_gel_vs__ketoconazole_2_cream_in_the_treatment_of_facial_seborrheic_dermatitis:_a_randomized_double_blind_study_ L2 - https://doi.org/10.1111/j.1468-3083.2006.01927.x DB - PRIME DP - Unbound Medicine ER -