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Relationship between markers of metabolic control and inflammation on severity of periodontal disease in patients with diabetes mellitus.
J Clin Periodontol. 2007 Feb; 34(2):118-23.JC

Abstract

AIM

The aim of this study was to investigate the relationship between markers of metabolic control and inflammation and periodontal disease parameters in patients with diabetes.

MATERIAL & METHODS

One hundred and eighty one adult patients with diabetes attending treatment at two diabetes centres were invited to participate in the study. Periodontal examination included full-mouth assessment for probing depths and bleeding on probing (BOP). Blood analyses were carried out for glycated haemoglobin, (HbA1c), high-sensitivity C reactive protein, (hsCRP) and lipid profile comprising total cholesterol, low-density lipoprotein cholesterol (LDL chol), high-density lipoprotein cholesterol (HDL chol) and triglycerides.

RESULTS

Upon multivariate analysis, periodontal disease severity in terms of increased percentage of BOP and mean percentage of sites with probing depths > or = 5 mm were found to be associated with inadequate glycaemic control as measured by HbA1c (p<0.01). HsCRP was also found to be a significant predictor for mean percentage of sites with probing depths > or = 5 mm (p<0.05). After controlling for age, gender, smoking habits and number of teeth, positive correlations were found between HbA1c and percentage sites with probing depths > or = 5 mm, percentage sites BOP, total cholesterol, LDL chol and triglycerides (p<0.05). Using the adjusted differences, subjects with acceptable glycaemic control (HbA1c < 8%) showed a lower percentage of sites with BOP and probing depths > or = 5 mm (p<0.05) when compared with those having inadequate glycaemic control. There was also a trend towards lower blood cholesterol in the well-controlled group.

CONCLUSION

The level of glycaemic control as measured by HbA1c emerged as the most consistent risk factor associated with the extent and severity of periodontal disease in this study cohort.

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Authors+Show Affiliations

Lim LP
Department of Preventive Dentistry, Faculty of Dentistry, National University of Singapore, Singapore. pndlimlp@nus.edu.sg
Tay FB
No affiliation info available
Sum CF
No affiliation info available
Thai AC
No affiliation info available

MeSH

AdultAgedBiomarkersBlood GlucoseC-Reactive ProteinCholesterol, HDLCholesterol, LDLDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleGlycated Hemoglobin AHumansInflammationMaleMiddle AgedPeriodontal DiseasesPeriodontal IndexRegression AnalysisRisk FactorsSeverity of Illness IndexStatistics, NonparametricTriglycerides

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17309586

Citation

Lim, L P., et al. "Relationship Between Markers of Metabolic Control and Inflammation On Severity of Periodontal Disease in Patients With Diabetes Mellitus." Journal of Clinical Periodontology, vol. 34, no. 2, 2007, pp. 118-23.
Lim LP, Tay FB, Sum CF, et al. Relationship between markers of metabolic control and inflammation on severity of periodontal disease in patients with diabetes mellitus. J Clin Periodontol. 2007;34(2):118-23.
Lim, L. P., Tay, F. B., Sum, C. F., & Thai, A. C. (2007). Relationship between markers of metabolic control and inflammation on severity of periodontal disease in patients with diabetes mellitus. Journal of Clinical Periodontology, 34(2), 118-23.
Lim LP, et al. Relationship Between Markers of Metabolic Control and Inflammation On Severity of Periodontal Disease in Patients With Diabetes Mellitus. J Clin Periodontol. 2007;34(2):118-23. PubMed PMID: 17309586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between markers of metabolic control and inflammation on severity of periodontal disease in patients with diabetes mellitus. AU - Lim,L P, AU - Tay,F B K, AU - Sum,C F, AU - Thai,A C, PY - 2007/2/21/pubmed PY - 2007/3/30/medline PY - 2007/2/21/entrez SP - 118 EP - 23 JF - Journal of clinical periodontology JO - J Clin Periodontol VL - 34 IS - 2 N2 - AIM: The aim of this study was to investigate the relationship between markers of metabolic control and inflammation and periodontal disease parameters in patients with diabetes. MATERIAL & METHODS: One hundred and eighty one adult patients with diabetes attending treatment at two diabetes centres were invited to participate in the study. Periodontal examination included full-mouth assessment for probing depths and bleeding on probing (BOP). Blood analyses were carried out for glycated haemoglobin, (HbA1c), high-sensitivity C reactive protein, (hsCRP) and lipid profile comprising total cholesterol, low-density lipoprotein cholesterol (LDL chol), high-density lipoprotein cholesterol (HDL chol) and triglycerides. RESULTS: Upon multivariate analysis, periodontal disease severity in terms of increased percentage of BOP and mean percentage of sites with probing depths > or = 5 mm were found to be associated with inadequate glycaemic control as measured by HbA1c (p<0.01). HsCRP was also found to be a significant predictor for mean percentage of sites with probing depths > or = 5 mm (p<0.05). After controlling for age, gender, smoking habits and number of teeth, positive correlations were found between HbA1c and percentage sites with probing depths > or = 5 mm, percentage sites BOP, total cholesterol, LDL chol and triglycerides (p<0.05). Using the adjusted differences, subjects with acceptable glycaemic control (HbA1c < 8%) showed a lower percentage of sites with BOP and probing depths > or = 5 mm (p<0.05) when compared with those having inadequate glycaemic control. There was also a trend towards lower blood cholesterol in the well-controlled group. CONCLUSION: The level of glycaemic control as measured by HbA1c emerged as the most consistent risk factor associated with the extent and severity of periodontal disease in this study cohort. SN - 0303-6979 UR - https://www.unboundmedicine.com/medline/citation/17309586/Relationship_between_markers_of_metabolic_control_and_inflammation_on_severity_of_periodontal_disease_in_patients_with_diabetes_mellitus_ L2 - https://doi.org/10.1111/j.1600-051X.2006.01032.x DB - PRIME DP - Unbound Medicine ER -