Tags

Type your tag names separated by a space and hit enter

[Fasting serum glucose and subsequent liver cancer risk in a Korean prospective cohort].
J Prev Med Public Health 2007; 40(1):23-8JP

Abstract

OBJECTIVES

Chronic infections with hepatitis B or C and alcoholic cirrhosis are three well-known major risk factors for liver cancer. Diabetes has also been suggested as a potential risk factor. However, the findings of previous studies have been controversial in terms of the causal association. Therefore, the aim of this study was to evaluate the association between serum glucose levels and liver cancer development in a Korean cohort.

METHODS

Thirty-six liver cancer cases were identified in the Korean Multi-Center Cancer Cohort (KMCC). Baseline information on lifestyle characteristics was obtained via questionnaire. Serum glucose levels were measured at the study's enrollment. Relative risks (RRs) were estimated using a Cox proportional hazard regression model. The adjusting variables included age, gender, smoking history, alcohol consumption, body mass index, and hepatitis B surface antigen (HBsAg) seropositivity.

RESULTS

The RRs of serum glucose for liver cancer were 1.20 (95% CI = 0.48-2.99) for the category of 100 to 125 mg/dL of serum glucose and 2.77 (95% CI = 1.24-6.18) for the > 126 mg/dL serum glucose category (both compared to the < 100 mg/dL category). In a subgroup analysis, the RR of serum glucose among those who were both HBsAg seronegative and non-drinkers was 4.46 (95% CL = 1.09-18.28) for those with glucose levels > 100 mg/dL.

CONCLUSIONS

The results of this study suggest that a high level of serum glucose can increase liver cancer risk independently of hepatitis infection and drinking history in Koreans. This study implies that glucose intolerance may be an independent risk factor for liver cancer.

Authors+Show Affiliations

Department of Preventive Medicine, Seoul National University College of Medicine.

Pub Type(s)

English Abstract
Journal Article

Language

kor

PubMed ID

17310595

Citation

Gwack, Jin, et al. "[Fasting Serum Glucose and Subsequent Liver Cancer Risk in a Korean Prospective Cohort]." Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, vol. 40, no. 1, 2007, pp. 23-8.
Gwack J, Hwang SS, Ko KP, et al. [Fasting serum glucose and subsequent liver cancer risk in a Korean prospective cohort]. J Prev Med Public Health. 2007;40(1):23-8.
Gwack, J., Hwang, S. S., Ko, K. P., Jun, J. K., Park, S. K., Chang, S. H., ... Yoo, K. Y. (2007). [Fasting serum glucose and subsequent liver cancer risk in a Korean prospective cohort]. Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, 40(1), pp. 23-8.
Gwack J, et al. [Fasting Serum Glucose and Subsequent Liver Cancer Risk in a Korean Prospective Cohort]. J Prev Med Public Health. 2007;40(1):23-8. PubMed PMID: 17310595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Fasting serum glucose and subsequent liver cancer risk in a Korean prospective cohort]. AU - Gwack,Jin, AU - Hwang,Seung-Sik, AU - Ko,Kwang-Pil, AU - Jun,Jae Kwan, AU - Park,Sue Kyung, AU - Chang,Soung-Hoon, AU - Shin,Hai-Rim, AU - Yoo,Keun-Young, PY - 2007/2/22/pubmed PY - 2007/4/4/medline PY - 2007/2/22/entrez SP - 23 EP - 8 JF - Journal of preventive medicine and public health = Yebang Uihakhoe chi JO - J Prev Med Public Health VL - 40 IS - 1 N2 - OBJECTIVES: Chronic infections with hepatitis B or C and alcoholic cirrhosis are three well-known major risk factors for liver cancer. Diabetes has also been suggested as a potential risk factor. However, the findings of previous studies have been controversial in terms of the causal association. Therefore, the aim of this study was to evaluate the association between serum glucose levels and liver cancer development in a Korean cohort. METHODS: Thirty-six liver cancer cases were identified in the Korean Multi-Center Cancer Cohort (KMCC). Baseline information on lifestyle characteristics was obtained via questionnaire. Serum glucose levels were measured at the study's enrollment. Relative risks (RRs) were estimated using a Cox proportional hazard regression model. The adjusting variables included age, gender, smoking history, alcohol consumption, body mass index, and hepatitis B surface antigen (HBsAg) seropositivity. RESULTS: The RRs of serum glucose for liver cancer were 1.20 (95% CI = 0.48-2.99) for the category of 100 to 125 mg/dL of serum glucose and 2.77 (95% CI = 1.24-6.18) for the > 126 mg/dL serum glucose category (both compared to the < 100 mg/dL category). In a subgroup analysis, the RR of serum glucose among those who were both HBsAg seronegative and non-drinkers was 4.46 (95% CL = 1.09-18.28) for those with glucose levels > 100 mg/dL. CONCLUSIONS: The results of this study suggest that a high level of serum glucose can increase liver cancer risk independently of hepatitis infection and drinking history in Koreans. This study implies that glucose intolerance may be an independent risk factor for liver cancer. SN - 1975-8375 UR - https://www.unboundmedicine.com/medline/citation/17310595/[Fasting_serum_glucose_and_subsequent_liver_cancer_risk_in_a_Korean_prospective_cohort]_ L2 - http://www.diseaseinfosearch.org/result/4278 DB - PRIME DP - Unbound Medicine ER -