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Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor.
Chem Commun (Camb). 2007 Mar 07CC

Abstract

Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2-10 mol% of catalyst.

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Authors+Show Affiliations

Harada S
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Takita R
No affiliation info available
Ohshima T
No affiliation info available
Matsunaga S
No affiliation info available
Shibasaki M
No affiliation info available

MeSH

AldehydesAlkynesCatalysisIndiumMolecular StructurePentanols

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17311130

Citation

Harada, Shinji, et al. "Ligand Accelerated indium(III)-catalyzed Asymmetric Alkynylation of Aldehydes With 2-methyl-3-butyn-2-ol as an Ethyne Equivalent Donor." Chemical Communications (Cambridge, England), 2007, pp. 948-50.
Harada S, Takita R, Ohshima T, et al. Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor. Chem Commun (Camb). 2007.
Harada, S., Takita, R., Ohshima, T., Matsunaga, S., & Shibasaki, M. (2007). Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor. Chemical Communications (Cambridge, England), (9), 948-50.
Harada S, et al. Ligand Accelerated indium(III)-catalyzed Asymmetric Alkynylation of Aldehydes With 2-methyl-3-butyn-2-ol as an Ethyne Equivalent Donor. Chem Commun (Camb). 2007 Mar 7;(9)948-50. PubMed PMID: 17311130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor. AU - Harada,Shinji, AU - Takita,Ryo, AU - Ohshima,Takashi, AU - Matsunaga,Shigeki, AU - Shibasaki,Masakatsu, Y1 - 2006/12/01/ PY - 2007/2/22/pubmed PY - 2007/4/27/medline PY - 2007/2/22/entrez SP - 948 EP - 50 JF - Chemical communications (Cambridge, England) JO - Chem Commun (Camb) IS - 9 N2 - Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2-10 mol% of catalyst. SN - 1359-7345 UR - https://www.unboundmedicine.com/medline/citation/17311130/Ligand_accelerated_indium_III__catalyzed_asymmetric_alkynylation_of_aldehydes_with_2_methyl_3_butyn_2_ol_as_an_ethyne_equivalent_donor_ L2 - https://doi.org/10.1039/b614958h DB - PRIME DP - Unbound Medicine ER -