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Renal impairment compromises the use of total homocysteine and methylmalonic acid but not total vitamin B12 and holotranscobalamin in screening for vitamin B12 deficiency in the aged.
Clin Chem Lab Med. 2007; 45(2):197-201.CC

Abstract

BACKGROUND

Vitamin B(12) deficiency and renal impairment are common in the aged, and therefore the screening test for vitamin B(12) deficiency should not be affected by renal function. Renal impairment has been associated with increased concentrations of plasma total homocysteine and methylmalonic acid, as well as increased total vitamin B(12) and holotranscobalamin concentrations.

METHODS

The effect of renal impairment on vitamin B(12)-related biochemical variables was assessed in 1011 aged subjects.

RESULTS

Renal function as indicated by serum cystatin C correlated strongly with plasma total homocysteine (r(s)=0.53, p<0.001) and serum methylmalonic acid (r(s)=0.27, p<0.001), but not with serum total vitamin B(12) (r(s)=-0.04, p=0.227) or holotranscobalamin (r(s)=-0.01, p=0.817).

CONCLUSIONS

Either total vitamin B(12) or holotranscobalamin rather than homocysteine or methylmalonic acid should be used when screening an aged population prone to renal impairment.

Links

Aggregator Full Text
Publisher Full Text
degruyter.com
degruyter.com

Authors+Show Affiliations

Loikas S
Department of Clinical Chemistry, Turku University Central Hospital, Turku, Finland. sailalo@utu.fi
Koskinen P
No affiliation info available
Irjala K
No affiliation info available
Löppönen M
No affiliation info available
Isoaho R
No affiliation info available
Kivelä SL
No affiliation info available
Pelliniemi TT
No affiliation info available

MeSH

AgedAged, 80 and overHomocysteineHumansKidney DiseasesMethodsMethylmalonic AcidTranscobalaminsVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17311508

Citation

Loikas, Saila, et al. "Renal Impairment Compromises the Use of Total Homocysteine and Methylmalonic Acid but Not Total Vitamin B12 and Holotranscobalamin in Screening for Vitamin B12 Deficiency in the Aged." Clinical Chemistry and Laboratory Medicine, vol. 45, no. 2, 2007, pp. 197-201.
Loikas S, Koskinen P, Irjala K, et al. Renal impairment compromises the use of total homocysteine and methylmalonic acid but not total vitamin B12 and holotranscobalamin in screening for vitamin B12 deficiency in the aged. Clin Chem Lab Med. 2007;45(2):197-201.
Loikas, S., Koskinen, P., Irjala, K., Löppönen, M., Isoaho, R., Kivelä, S. L., & Pelliniemi, T. T. (2007). Renal impairment compromises the use of total homocysteine and methylmalonic acid but not total vitamin B12 and holotranscobalamin in screening for vitamin B12 deficiency in the aged. Clinical Chemistry and Laboratory Medicine, 45(2), 197-201.
Loikas S, et al. Renal Impairment Compromises the Use of Total Homocysteine and Methylmalonic Acid but Not Total Vitamin B12 and Holotranscobalamin in Screening for Vitamin B12 Deficiency in the Aged. Clin Chem Lab Med. 2007;45(2):197-201. PubMed PMID: 17311508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal impairment compromises the use of total homocysteine and methylmalonic acid but not total vitamin B12 and holotranscobalamin in screening for vitamin B12 deficiency in the aged. AU - Loikas,Saila, AU - Koskinen,Pertti, AU - Irjala,Kerttu, AU - Löppönen,Minna, AU - Isoaho,Raimo, AU - Kivelä,Sirkka-Liisa, AU - Pelliniemi,Tarja-Terttu, PY - 2007/2/22/pubmed PY - 2007/4/6/medline PY - 2007/2/22/entrez SP - 197 EP - 201 JF - Clinical chemistry and laboratory medicine JO - Clin Chem Lab Med VL - 45 IS - 2 N2 - BACKGROUND: Vitamin B(12) deficiency and renal impairment are common in the aged, and therefore the screening test for vitamin B(12) deficiency should not be affected by renal function. Renal impairment has been associated with increased concentrations of plasma total homocysteine and methylmalonic acid, as well as increased total vitamin B(12) and holotranscobalamin concentrations. METHODS: The effect of renal impairment on vitamin B(12)-related biochemical variables was assessed in 1011 aged subjects. RESULTS: Renal function as indicated by serum cystatin C correlated strongly with plasma total homocysteine (r(s)=0.53, p<0.001) and serum methylmalonic acid (r(s)=0.27, p<0.001), but not with serum total vitamin B(12) (r(s)=-0.04, p=0.227) or holotranscobalamin (r(s)=-0.01, p=0.817). CONCLUSIONS: Either total vitamin B(12) or holotranscobalamin rather than homocysteine or methylmalonic acid should be used when screening an aged population prone to renal impairment. SN - 1434-6621 UR - https://www.unboundmedicine.com/medline/citation/17311508/Renal_impairment_compromises_the_use_of_total_homocysteine_and_methylmalonic_acid_but_not_total_vitamin_B12_and_holotranscobalamin_in_screening_for_vitamin_B12_deficiency_in_the_aged_ L2 - https://www.degruyter.com/document/doi/10.1515/CCLM.2007.028 DB - PRIME DP - Unbound Medicine ER -