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Long-term treatment of patients with gastro-oesophageal reflux disease in routine care - results from the ProGERD study.
Aliment Pharmacol Ther 2007; 25(6):715-22AP

Abstract

BACKGROUND

Gastro-oesophageal reflux disease (GERD) is a common condition frequently requiring long-term pharmacological treatment.

AIM

To describe the long-term pattern of GERD medication use in GERD patients receiving routine care.

METHODS

Patients were recruited as part of the ongoing ProGERD study, a 10-year-cohort study including 6215 patients at baseline. GERD medication and symptoms were assessed with patient questionnaires. During follow-up, medical treatment was prescribed by participating primary care physicians. Associations between patient characteristics and medication were analysed by logistic regression.

RESULTS

The percentage of patients who reported using any GERD medication remained constant from year 1 to year 4 (74%, 74%, 73% and 71%). Of patients who reported using GERD medication, the majority were taking proton pump inhibitors (PPI) (79%, 84%, 85%, and 87%). Continuous PPI intake was the predominant prescription pattern (53%, 49%, 56% and 56%), followed by on-demand treatment (26%, 35%, 29% and 29%). Continuous PPI intake was strongly associated with the presence of erosive GERD.

CONCLUSION

Three-quarters of the GERD population in our study reported long-term treatment with a PPI. Continuous PPI intake was the predominant treatment pattern, and the proportion of patients taking a PPI on a continuous basis remained constant over time.

Authors+Show Affiliations

Institute for Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin, Germany. marc.nocon@charite.de

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17311605

Citation

Nocon, M, et al. "Long-term Treatment of Patients With Gastro-oesophageal Reflux Disease in Routine Care - Results From the ProGERD Study." Alimentary Pharmacology & Therapeutics, vol. 25, no. 6, 2007, pp. 715-22.
Nocon M, Labenz J, Jaspersen D, et al. Long-term treatment of patients with gastro-oesophageal reflux disease in routine care - results from the ProGERD study. Aliment Pharmacol Ther. 2007;25(6):715-22.
Nocon, M., Labenz, J., Jaspersen, D., Meyer-Sabellek, W., Stolte, M., Lind, T., ... Willich, S. N. (2007). Long-term treatment of patients with gastro-oesophageal reflux disease in routine care - results from the ProGERD study. Alimentary Pharmacology & Therapeutics, 25(6), pp. 715-22.
Nocon M, et al. Long-term Treatment of Patients With Gastro-oesophageal Reflux Disease in Routine Care - Results From the ProGERD Study. Aliment Pharmacol Ther. 2007 Mar 15;25(6):715-22. PubMed PMID: 17311605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term treatment of patients with gastro-oesophageal reflux disease in routine care - results from the ProGERD study. AU - Nocon,M, AU - Labenz,J, AU - Jaspersen,D, AU - Meyer-Sabellek,W, AU - Stolte,M, AU - Lind,T, AU - Malfertheiner,P, AU - Willich,S N, PY - 2007/2/22/pubmed PY - 2007/6/30/medline PY - 2007/2/22/entrez SP - 715 EP - 22 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 25 IS - 6 N2 - BACKGROUND: Gastro-oesophageal reflux disease (GERD) is a common condition frequently requiring long-term pharmacological treatment. AIM: To describe the long-term pattern of GERD medication use in GERD patients receiving routine care. METHODS: Patients were recruited as part of the ongoing ProGERD study, a 10-year-cohort study including 6215 patients at baseline. GERD medication and symptoms were assessed with patient questionnaires. During follow-up, medical treatment was prescribed by participating primary care physicians. Associations between patient characteristics and medication were analysed by logistic regression. RESULTS: The percentage of patients who reported using any GERD medication remained constant from year 1 to year 4 (74%, 74%, 73% and 71%). Of patients who reported using GERD medication, the majority were taking proton pump inhibitors (PPI) (79%, 84%, 85%, and 87%). Continuous PPI intake was the predominant prescription pattern (53%, 49%, 56% and 56%), followed by on-demand treatment (26%, 35%, 29% and 29%). Continuous PPI intake was strongly associated with the presence of erosive GERD. CONCLUSION: Three-quarters of the GERD population in our study reported long-term treatment with a PPI. Continuous PPI intake was the predominant treatment pattern, and the proportion of patients taking a PPI on a continuous basis remained constant over time. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/17311605/Long_term_treatment_of_patients_with_gastro_oesophageal_reflux_disease_in_routine_care___results_from_the_ProGERD_study_ L2 - https://doi.org/10.1111/j.1365-2036.2007.03249.x DB - PRIME DP - Unbound Medicine ER -