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Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane.
Anesth Analg. 2007 Mar; 104(3):563-8.A&A

Abstract

In this study we investigated whether the novel reversal drug, sugammadex, is equally effective at reversing rocuronium-induced neuromuscular block (NMB) in patients under propofol or sevoflurane maintenance anesthesia. After receiving propofol for induction, patients were randomized to propofol (n = 21) or sevoflurane (n = 21). Rocuronium 0.6 mg/kg was administered for tracheal intubation. NMB was monitored using acceleromyography. At reappearance of the second twitch of the train-of-four ratio, sugammadex 2.0 mg/kg was administered by IV bolus. The primary end-point was time from start of sugammadex administration to recovery of train-of-four ratio to 0.9. Mean recovery time was 1.8 min after both propofol and sevoflurane anesthesia. The 95% confidence interval for the difference in recovery time between the 2 groups (-0.5 to +0.4 min) was well within the predefined equivalence interval (-1 to +1 min), indicating that recovery from NMB was unaffected by maintenance anesthesia. Thirteen patients (propofol n = 4; sevoflurane n = 9) experienced adverse events; these were treatment-related in 4 patients (propofol n = 3; sevoflurane n = 1). There were no treatment-related serious adverse events and no discontinuations or deaths. No residual paralysis occurred. The safety profile of sugammadex was somewhat more favorable under propofol than under sevoflurane anesthesia.

Authors+Show Affiliations

Department of Anesthesiology, University Hospitals Leuven, KU Leuven, Leuven, Belgium. bernard.vanacker@uz.kuleuven.ac.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase II
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17312209

Citation

Vanacker, Bernard F., et al. "Reversal of Rocuronium-induced Neuromuscular Block With the Novel Drug Sugammadex Is Equally Effective Under Maintenance Anesthesia With Propofol or Sevoflurane." Anesthesia and Analgesia, vol. 104, no. 3, 2007, pp. 563-8.
Vanacker BF, Vermeyen KM, Struys MM, et al. Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane. Anesth Analg. 2007;104(3):563-8.
Vanacker, B. F., Vermeyen, K. M., Struys, M. M., Rietbergen, H., Vandermeersch, E., Saldien, V., Kalmar, A. F., & Prins, M. E. (2007). Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane. Anesthesia and Analgesia, 104(3), 563-8.
Vanacker BF, et al. Reversal of Rocuronium-induced Neuromuscular Block With the Novel Drug Sugammadex Is Equally Effective Under Maintenance Anesthesia With Propofol or Sevoflurane. Anesth Analg. 2007;104(3):563-8. PubMed PMID: 17312209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane. AU - Vanacker,Bernard F, AU - Vermeyen,Karel M, AU - Struys,Michel M R F, AU - Rietbergen,Henk, AU - Vandermeersch,Eugene, AU - Saldien,Vera, AU - Kalmar,Alain F, AU - Prins,Martine E, PY - 2007/2/22/pubmed PY - 2007/3/28/medline PY - 2007/2/22/entrez SP - 563 EP - 8 JF - Anesthesia and analgesia JO - Anesth. Analg. VL - 104 IS - 3 N2 - In this study we investigated whether the novel reversal drug, sugammadex, is equally effective at reversing rocuronium-induced neuromuscular block (NMB) in patients under propofol or sevoflurane maintenance anesthesia. After receiving propofol for induction, patients were randomized to propofol (n = 21) or sevoflurane (n = 21). Rocuronium 0.6 mg/kg was administered for tracheal intubation. NMB was monitored using acceleromyography. At reappearance of the second twitch of the train-of-four ratio, sugammadex 2.0 mg/kg was administered by IV bolus. The primary end-point was time from start of sugammadex administration to recovery of train-of-four ratio to 0.9. Mean recovery time was 1.8 min after both propofol and sevoflurane anesthesia. The 95% confidence interval for the difference in recovery time between the 2 groups (-0.5 to +0.4 min) was well within the predefined equivalence interval (-1 to +1 min), indicating that recovery from NMB was unaffected by maintenance anesthesia. Thirteen patients (propofol n = 4; sevoflurane n = 9) experienced adverse events; these were treatment-related in 4 patients (propofol n = 3; sevoflurane n = 1). There were no treatment-related serious adverse events and no discontinuations or deaths. No residual paralysis occurred. The safety profile of sugammadex was somewhat more favorable under propofol than under sevoflurane anesthesia. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/17312209/Reversal_of_rocuronium_induced_neuromuscular_block_with_the_novel_drug_sugammadex_is_equally_effective_under_maintenance_anesthesia_with_propofol_or_sevoflurane_ L2 - http://dx.doi.org/10.1213/01.ane.0000231829.29177.8e DB - PRIME DP - Unbound Medicine ER -